Carboplatin +/- topotecan ophthalmic artery chemosurgery for intraocular retinoblastoma.
PURPOSE: Carboplatin administered systemically or periocularly can result in dramatic and prompt regression of retinoblastoma. However, both routes are rarely curative alone and have undesirable side effects. We aimed to assess the efficacy and toxicity of carboplatin +/- topotecan delivered by opht...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3749169?pdf=render |
| _version_ | 1819056407923654656 |
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| author | Jasmine H Francis Y Pierre Gobin Ira J Dunkel Brian P Marr Scott E Brodie Gowtham Jonna David H Abramson |
| author_facet | Jasmine H Francis Y Pierre Gobin Ira J Dunkel Brian P Marr Scott E Brodie Gowtham Jonna David H Abramson |
| author_sort | Jasmine H Francis |
| collection | DOAJ |
| description | PURPOSE: Carboplatin administered systemically or periocularly can result in dramatic and prompt regression of retinoblastoma. However, both routes are rarely curative alone and have undesirable side effects. We aimed to assess the efficacy and toxicity of carboplatin +/- topotecan delivered by ophthalmic artery chemosurgery whereby chemotherapy is infused into the eye via the ophthalmic artery. METHODS: This retrospective, IRB-approved study investigated retinoblastoma patients whom received carboplatin +/- topotecan ophthalmic artery chemosurgery. Patient survival, ocular survival, hematologic toxicity, ocular toxicity, second cancer development and electroretinogram response were all evaluated. RESULTS: 57 carboplatin +/- topotecan infusions (of 111 total) were performed in 31 eyes of 24 patients. The remaining infusions were melphalan-containing. All patients were alive and no patient developed a second malignancy at a median follow up of 25 months. The Kaplan-Meier estimate of ocular survival at two years was 89.9% (95% confidence interval [CI], 82.1-97.9%) for all eyes. Grade 3 or 4 neutropenia developed in two patients and one patient developed metastatic disease. By univariate analysis, neither increasing maximum carboplatin/topotecan dose nor cumulative carboplatin/topotecan dose was associated with statistically significant reduction in the electroretinogram responses. CONCLUSION: Carboplatin +/- topotecan infusions are effective for ophthalmic artery chemosurgery in retinoblastoma: they demonstrate low hematologic and ocular toxicity and no statistically significant influence on electroretinogram responses, and used in conjunction with melphalan-containing OAC, demonstrate excellent patient survival and satisfactory ocular survival. |
| first_indexed | 2024-12-21T13:22:56Z |
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| id | doaj.art-c7327ccbeb7246c494d81abb80c8c5a9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T13:22:56Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c7327ccbeb7246c494d81abb80c8c5a92022-12-21T19:02:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0188e7244110.1371/journal.pone.0072441Carboplatin +/- topotecan ophthalmic artery chemosurgery for intraocular retinoblastoma.Jasmine H FrancisY Pierre GobinIra J DunkelBrian P MarrScott E BrodieGowtham JonnaDavid H AbramsonPURPOSE: Carboplatin administered systemically or periocularly can result in dramatic and prompt regression of retinoblastoma. However, both routes are rarely curative alone and have undesirable side effects. We aimed to assess the efficacy and toxicity of carboplatin +/- topotecan delivered by ophthalmic artery chemosurgery whereby chemotherapy is infused into the eye via the ophthalmic artery. METHODS: This retrospective, IRB-approved study investigated retinoblastoma patients whom received carboplatin +/- topotecan ophthalmic artery chemosurgery. Patient survival, ocular survival, hematologic toxicity, ocular toxicity, second cancer development and electroretinogram response were all evaluated. RESULTS: 57 carboplatin +/- topotecan infusions (of 111 total) were performed in 31 eyes of 24 patients. The remaining infusions were melphalan-containing. All patients were alive and no patient developed a second malignancy at a median follow up of 25 months. The Kaplan-Meier estimate of ocular survival at two years was 89.9% (95% confidence interval [CI], 82.1-97.9%) for all eyes. Grade 3 or 4 neutropenia developed in two patients and one patient developed metastatic disease. By univariate analysis, neither increasing maximum carboplatin/topotecan dose nor cumulative carboplatin/topotecan dose was associated with statistically significant reduction in the electroretinogram responses. CONCLUSION: Carboplatin +/- topotecan infusions are effective for ophthalmic artery chemosurgery in retinoblastoma: they demonstrate low hematologic and ocular toxicity and no statistically significant influence on electroretinogram responses, and used in conjunction with melphalan-containing OAC, demonstrate excellent patient survival and satisfactory ocular survival.http://europepmc.org/articles/PMC3749169?pdf=render |
| spellingShingle | Jasmine H Francis Y Pierre Gobin Ira J Dunkel Brian P Marr Scott E Brodie Gowtham Jonna David H Abramson Carboplatin +/- topotecan ophthalmic artery chemosurgery for intraocular retinoblastoma. PLoS ONE |
| title | Carboplatin +/- topotecan ophthalmic artery chemosurgery for intraocular retinoblastoma. |
| title_full | Carboplatin +/- topotecan ophthalmic artery chemosurgery for intraocular retinoblastoma. |
| title_fullStr | Carboplatin +/- topotecan ophthalmic artery chemosurgery for intraocular retinoblastoma. |
| title_full_unstemmed | Carboplatin +/- topotecan ophthalmic artery chemosurgery for intraocular retinoblastoma. |
| title_short | Carboplatin +/- topotecan ophthalmic artery chemosurgery for intraocular retinoblastoma. |
| title_sort | carboplatin topotecan ophthalmic artery chemosurgery for intraocular retinoblastoma |
| url | http://europepmc.org/articles/PMC3749169?pdf=render |
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