Contact Heat Evoked Potentials Are Responsive to Peripheral Sensitization: Requisite Stimulation Parameters
The sensitizing effect of capsaicin has been previously characterized using laser and contact heat evoked potentials (LEPs and CHEPs) by stimulating in the primary area of hyperalgesia. Interestingly, only CHEPs reveal changes consistent with notion of peripheral sensitization (i.e., reduced latenci...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnhum.2019.00459/full |
| _version_ | 1819176318178164736 |
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| author | Lukas D. Linde Lukas D. Linde Jenny Haefeli Catherine R. Jutzeler Catherine R. Jutzeler Catherine R. Jutzeler Jan Rosner Jan Rosner Jessica McDougall Jessica McDougall Armin Curt John L. K. Kramer John L. K. Kramer |
| author_facet | Lukas D. Linde Lukas D. Linde Jenny Haefeli Catherine R. Jutzeler Catherine R. Jutzeler Catherine R. Jutzeler Jan Rosner Jan Rosner Jessica McDougall Jessica McDougall Armin Curt John L. K. Kramer John L. K. Kramer |
| author_sort | Lukas D. Linde |
| collection | DOAJ |
| description | The sensitizing effect of capsaicin has been previously characterized using laser and contact heat evoked potentials (LEPs and CHEPs) by stimulating in the primary area of hyperalgesia. Interestingly, only CHEPs reveal changes consistent with notion of peripheral sensitization (i.e., reduced latencies). The aim of this study was to investigate contact heat stimulation parameters necessary to detect peripheral sensitization related to the topical application of capsaicin, and therefore significantly improve the current method of measuring peripheral sensitization via CHEPs. Rapid contact heat stimulation (70°C/s) was applied from three different baseline temperatures (35, 38.5, and 42°C) to a 52°C peak temperature, before and after the topical application of capsaicin on the hand dorsum. Increased pain ratings in the primary area of hyperalgesia were accompanied by reduced N2 latency. Changes in N2 latency were, however, only significant following stimulation from 35 and 38.5°C baseline temperatures. These findings suggest that earlier recruitment of capsaicin-sensitized afferents occurs between 35 and 42°C, as stimulations from 42°C baseline were unchanged by capsaicin. This is in line with reduced thresholds of type II A-delta mechanoheat (AMH) nociceptors following sensitization. Conventional CHEP stimulation, with a baseline temperature below 42°C, is well suited to objectively detect evidence of peripheral sensitization. |
| first_indexed | 2024-12-22T21:08:51Z |
| format | Article |
| id | doaj.art-c7369c5bfa9e40f29584d9655e75c889 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-22T21:08:51Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-c7369c5bfa9e40f29584d9655e75c8892022-12-21T18:12:36ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612020-01-011310.3389/fnhum.2019.00459500298Contact Heat Evoked Potentials Are Responsive to Peripheral Sensitization: Requisite Stimulation ParametersLukas D. Linde0Lukas D. Linde1Jenny Haefeli2Catherine R. Jutzeler3Catherine R. Jutzeler4Catherine R. Jutzeler5Jan Rosner6Jan Rosner7Jessica McDougall8Jessica McDougall9Armin Curt10John L. K. Kramer11John L. K. Kramer12ICORD, The University of British Columbia, Vancouver, BC, CanadaSchool of Kinesiology, The University of British Columbia, Vancouver, BC, CanadaBrain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, United StatesICORD, The University of British Columbia, Vancouver, BC, CanadaSchool of Kinesiology, The University of British Columbia, Vancouver, BC, CanadaSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, SwitzerlandSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, SwitzerlandDepartment of Neurology, University Hospital Bern, Inselspital, University of Bern, Bern, SwitzerlandICORD, The University of British Columbia, Vancouver, BC, CanadaSchool of Rehabilitation Sciences, Faculty of Medicine, The University of British Columbia, Vancouver, BC, CanadaSpinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, SwitzerlandICORD, The University of British Columbia, Vancouver, BC, CanadaSchool of Kinesiology, The University of British Columbia, Vancouver, BC, CanadaThe sensitizing effect of capsaicin has been previously characterized using laser and contact heat evoked potentials (LEPs and CHEPs) by stimulating in the primary area of hyperalgesia. Interestingly, only CHEPs reveal changes consistent with notion of peripheral sensitization (i.e., reduced latencies). The aim of this study was to investigate contact heat stimulation parameters necessary to detect peripheral sensitization related to the topical application of capsaicin, and therefore significantly improve the current method of measuring peripheral sensitization via CHEPs. Rapid contact heat stimulation (70°C/s) was applied from three different baseline temperatures (35, 38.5, and 42°C) to a 52°C peak temperature, before and after the topical application of capsaicin on the hand dorsum. Increased pain ratings in the primary area of hyperalgesia were accompanied by reduced N2 latency. Changes in N2 latency were, however, only significant following stimulation from 35 and 38.5°C baseline temperatures. These findings suggest that earlier recruitment of capsaicin-sensitized afferents occurs between 35 and 42°C, as stimulations from 42°C baseline were unchanged by capsaicin. This is in line with reduced thresholds of type II A-delta mechanoheat (AMH) nociceptors following sensitization. Conventional CHEP stimulation, with a baseline temperature below 42°C, is well suited to objectively detect evidence of peripheral sensitization.https://www.frontiersin.org/article/10.3389/fnhum.2019.00459/fullcapsaicincontact heat evoked potentialstype II A mechanoheat nociceptorsEEGhyperalgesia |
| spellingShingle | Lukas D. Linde Lukas D. Linde Jenny Haefeli Catherine R. Jutzeler Catherine R. Jutzeler Catherine R. Jutzeler Jan Rosner Jan Rosner Jessica McDougall Jessica McDougall Armin Curt John L. K. Kramer John L. K. Kramer Contact Heat Evoked Potentials Are Responsive to Peripheral Sensitization: Requisite Stimulation Parameters Frontiers in Human Neuroscience capsaicin contact heat evoked potentials type II A mechanoheat nociceptors EEG hyperalgesia |
| title | Contact Heat Evoked Potentials Are Responsive to Peripheral Sensitization: Requisite Stimulation Parameters |
| title_full | Contact Heat Evoked Potentials Are Responsive to Peripheral Sensitization: Requisite Stimulation Parameters |
| title_fullStr | Contact Heat Evoked Potentials Are Responsive to Peripheral Sensitization: Requisite Stimulation Parameters |
| title_full_unstemmed | Contact Heat Evoked Potentials Are Responsive to Peripheral Sensitization: Requisite Stimulation Parameters |
| title_short | Contact Heat Evoked Potentials Are Responsive to Peripheral Sensitization: Requisite Stimulation Parameters |
| title_sort | contact heat evoked potentials are responsive to peripheral sensitization requisite stimulation parameters |
| topic | capsaicin contact heat evoked potentials type II A mechanoheat nociceptors EEG hyperalgesia |
| url | https://www.frontiersin.org/article/10.3389/fnhum.2019.00459/full |
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