Murine models of idiopathic inflammatory myopathy
AbstractIdiopathic inflammatory myopathies (IIMs) are characterized by inflammation of muscles and other organs. Several myositis-specific autoantibodies (MSAs) have been identified in IIMs and were found to be associated with distinct clinical features. Although MSAs are valuable for the diagnosis...
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Format: | Article |
Language: | English |
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Taylor & Francis Group
2023-01-01
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Series: | Immunological Medicine |
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Online Access: | https://www.tandfonline.com/doi/10.1080/25785826.2022.2137968 |
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author | Risa Konishi Yuki Ichimura Naoko Okiyama |
author_facet | Risa Konishi Yuki Ichimura Naoko Okiyama |
author_sort | Risa Konishi |
collection | DOAJ |
description | AbstractIdiopathic inflammatory myopathies (IIMs) are characterized by inflammation of muscles and other organs. Several myositis-specific autoantibodies (MSAs) have been identified in IIMs and were found to be associated with distinct clinical features. Although MSAs are valuable for the diagnosis of IIMs, the pathogenic roles of these antibodies remain unknown. To investigate the pathogenesis of IIMs, several animal models of experimental myositis have been established. Classical murine models of autoimmune myositis, experimental autoimmune myositis, and C protein-induced myositis are established by immunization with muscle-specific antigens, myosin, and skeletal C protein, respectively. Furthermore, a murine model of experimental myositis was generated by immunization with a murine recombinant histidyl-tRNA synthetase, Jo-1, in which muscle and lung inflammation reflecting anti-synthetase syndrome are induced depending on acquired immunity. Recently, the transfer of human IgGs from patients with immune-mediated necrotizing myopathy, comprising anti-signal recognition particles and anti-3-hydroxy-3-methylglutaryl coenzyme A reductase antibodies, was found to induce complement-mediated myositis in recipient mice. CD8+ T cell-mediated myositis can be established depending on autoimmunity against transcriptional intermediary factor 1γ (TIF1γ), an autoantigen for MSAs induced by recombinant human TIF1γ immunization. These new murine models reflecting MSA-related IIMs are useful tools for accurately understanding the pathological mechanisms underlying IIMs. |
first_indexed | 2024-04-10T16:26:11Z |
format | Article |
id | doaj.art-c738d3754d2745b7bfc3fb67f12240d0 |
institution | Directory Open Access Journal |
issn | 2578-5826 |
language | English |
last_indexed | 2024-04-10T16:26:11Z |
publishDate | 2023-01-01 |
publisher | Taylor & Francis Group |
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series | Immunological Medicine |
spelling | doaj.art-c738d3754d2745b7bfc3fb67f12240d02023-02-09T05:34:36ZengTaylor & Francis GroupImmunological Medicine2578-58262023-01-0146191410.1080/25785826.2022.2137968Murine models of idiopathic inflammatory myopathyRisa Konishi0Yuki Ichimura1Naoko Okiyama2Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, JapanAbstractIdiopathic inflammatory myopathies (IIMs) are characterized by inflammation of muscles and other organs. Several myositis-specific autoantibodies (MSAs) have been identified in IIMs and were found to be associated with distinct clinical features. Although MSAs are valuable for the diagnosis of IIMs, the pathogenic roles of these antibodies remain unknown. To investigate the pathogenesis of IIMs, several animal models of experimental myositis have been established. Classical murine models of autoimmune myositis, experimental autoimmune myositis, and C protein-induced myositis are established by immunization with muscle-specific antigens, myosin, and skeletal C protein, respectively. Furthermore, a murine model of experimental myositis was generated by immunization with a murine recombinant histidyl-tRNA synthetase, Jo-1, in which muscle and lung inflammation reflecting anti-synthetase syndrome are induced depending on acquired immunity. Recently, the transfer of human IgGs from patients with immune-mediated necrotizing myopathy, comprising anti-signal recognition particles and anti-3-hydroxy-3-methylglutaryl coenzyme A reductase antibodies, was found to induce complement-mediated myositis in recipient mice. CD8+ T cell-mediated myositis can be established depending on autoimmunity against transcriptional intermediary factor 1γ (TIF1γ), an autoantigen for MSAs induced by recombinant human TIF1γ immunization. These new murine models reflecting MSA-related IIMs are useful tools for accurately understanding the pathological mechanisms underlying IIMs.https://www.tandfonline.com/doi/10.1080/25785826.2022.2137968Murine modelidiopathic inflammatory myopathydermatomyositismyositis-specific autoantibodyTIF1γ |
spellingShingle | Risa Konishi Yuki Ichimura Naoko Okiyama Murine models of idiopathic inflammatory myopathy Immunological Medicine Murine model idiopathic inflammatory myopathy dermatomyositis myositis-specific autoantibody TIF1γ |
title | Murine models of idiopathic inflammatory myopathy |
title_full | Murine models of idiopathic inflammatory myopathy |
title_fullStr | Murine models of idiopathic inflammatory myopathy |
title_full_unstemmed | Murine models of idiopathic inflammatory myopathy |
title_short | Murine models of idiopathic inflammatory myopathy |
title_sort | murine models of idiopathic inflammatory myopathy |
topic | Murine model idiopathic inflammatory myopathy dermatomyositis myositis-specific autoantibody TIF1γ |
url | https://www.tandfonline.com/doi/10.1080/25785826.2022.2137968 |
work_keys_str_mv | AT risakonishi murinemodelsofidiopathicinflammatorymyopathy AT yukiichimura murinemodelsofidiopathicinflammatorymyopathy AT naokookiyama murinemodelsofidiopathicinflammatorymyopathy |