Erythrodermic CD4/CD8 Double-Negative Mycosis Fungoides: A Case Report
Cutaneous T-cell lymphoma (CTCL) describes a group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin. Mycosis fungoides (MF) represents the most common type of CTCL and accounts for ∼60% of all primary cutaneous lymphomas. Apart from the classic t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2021-03-01
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| Series: | Case Reports in Oncology |
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| Online Access: | https://www.karger.com/Article/FullText/512822 |
| _version_ | 1818933177953026048 |
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| author | Monira Abdullah Alnasser Nour Marwan AlKhawajah Nada Ghazi AlQadri Asem Mustafa Shadid Fahad M. Alsaif |
| author_facet | Monira Abdullah Alnasser Nour Marwan AlKhawajah Nada Ghazi AlQadri Asem Mustafa Shadid Fahad M. Alsaif |
| author_sort | Monira Abdullah Alnasser |
| collection | DOAJ |
| description | Cutaneous T-cell lymphoma (CTCL) describes a group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin. Mycosis fungoides (MF) represents the most common type of CTCL and accounts for ∼60% of all primary cutaneous lymphomas. Apart from the classic type of MF, many clinical and histopathologic variants have been described. The malignant lymphocytes in MF are usually CD3, CD4 and CD45RO positive and CD8 negative. An unusual immunohistochemical profile of a CD4-negative and CD8-positive mature T-cell phenotype has been reported in a minority of patients; up to 20% of early-stage MF demonstrates a CD8-positive phenotype. There are only a few cases of a double-negative CD4/CD8 MF phenotype reported in the literature. We present the case of a 60-year-old male presenting a double-negative CD4/CD8 MF phenotype. |
| first_indexed | 2024-12-20T04:44:15Z |
| format | Article |
| id | doaj.art-c73ade423f0e487a80a300015ced44c7 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-20T04:44:15Z |
| publishDate | 2021-03-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-c73ade423f0e487a80a300015ced44c72022-12-21T19:53:03ZengKarger PublishersCase Reports in Oncology1662-65752021-03-0114125626110.1159/000512822512822Erythrodermic CD4/CD8 Double-Negative Mycosis Fungoides: A Case ReportMonira Abdullah AlnasserNour Marwan AlKhawajahNada Ghazi AlQadriAsem Mustafa ShadidFahad M. AlsaifCutaneous T-cell lymphoma (CTCL) describes a group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin. Mycosis fungoides (MF) represents the most common type of CTCL and accounts for ∼60% of all primary cutaneous lymphomas. Apart from the classic type of MF, many clinical and histopathologic variants have been described. The malignant lymphocytes in MF are usually CD3, CD4 and CD45RO positive and CD8 negative. An unusual immunohistochemical profile of a CD4-negative and CD8-positive mature T-cell phenotype has been reported in a minority of patients; up to 20% of early-stage MF demonstrates a CD8-positive phenotype. There are only a few cases of a double-negative CD4/CD8 MF phenotype reported in the literature. We present the case of a 60-year-old male presenting a double-negative CD4/CD8 MF phenotype.https://www.karger.com/Article/FullText/512822mycosis fungoidescutaneous t-cell lymphomaserythrodermic mycosis fungoidescd4/cd8 double-negative mycosis fungoides |
| spellingShingle | Monira Abdullah Alnasser Nour Marwan AlKhawajah Nada Ghazi AlQadri Asem Mustafa Shadid Fahad M. Alsaif Erythrodermic CD4/CD8 Double-Negative Mycosis Fungoides: A Case Report Case Reports in Oncology mycosis fungoides cutaneous t-cell lymphomas erythrodermic mycosis fungoides cd4/cd8 double-negative mycosis fungoides |
| title | Erythrodermic CD4/CD8 Double-Negative Mycosis Fungoides: A Case Report |
| title_full | Erythrodermic CD4/CD8 Double-Negative Mycosis Fungoides: A Case Report |
| title_fullStr | Erythrodermic CD4/CD8 Double-Negative Mycosis Fungoides: A Case Report |
| title_full_unstemmed | Erythrodermic CD4/CD8 Double-Negative Mycosis Fungoides: A Case Report |
| title_short | Erythrodermic CD4/CD8 Double-Negative Mycosis Fungoides: A Case Report |
| title_sort | erythrodermic cd4 cd8 double negative mycosis fungoides a case report |
| topic | mycosis fungoides cutaneous t-cell lymphomas erythrodermic mycosis fungoides cd4/cd8 double-negative mycosis fungoides |
| url | https://www.karger.com/Article/FullText/512822 |
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