Association Between the -1031 (T/C) Polymorphism of TNF-α Gene and Biochemical Factors in Women With Polycystic Ovary Syndrome
Background Tumor Necrosis Factor Alpha (TNF-α) gene, as an inflammatory factor, plays an important role in reproductive physiology, especially in women with Polycystic Ovary Syndrome (PCOS). Objective This study aims to investigate the relationship between the -1031 T/C polymorphism of TNF-α gene...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Qazvin University of Medical Sciences & Health Services
2021-03-01
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| Series: | The Journal of Qazvin University of Medical Sciences |
| Subjects: | |
| Online Access: | https://journal.qums.ac.ir/article-1-3054-en.html |
| Summary: | Background Tumor Necrosis Factor Alpha (TNF-α) gene, as an inflammatory factor, plays an important
role in reproductive physiology, especially in women with Polycystic Ovary Syndrome (PCOS).
Objective This study aims to investigate the relationship between the -1031 T/C polymorphism of TNF-α
gene and biochemical factors in women with PCOS.
Methods In this case-control study, participants were 106 women with PCOS and 114 healthy women
referred to Kosar Hospital in Qazvin, Iran. The TNF-α gene’s polymorphism was determined using Polymerase
Chain Reaction (PCR) technique and PCR-Restriction Fragment Length Polymorphism (PCR-RFLP)
method. Biochemical factors of serum levels were also measured in two groups. Logistic regression analysis
examined the relationship between the frequency of alleles in different states and the risk of PCOS.
Findings There were statistically significant difference in the mean levels of total cholesterol, triglycerides,
testosterone, two-hour blood glucose and body mass index between the groups, whose values were
higher in women with PCOS compared to healthy women (P<0.001). In women with PCOS, the mean serum
levels of triglyceride and high-density lipoprotein were significantly different between the three TT,
CC, TC genotypes of TNF-α gene polymorphism (P<0.05). The results of regression analysis showed that
the TT genotype had significant association with the risk of PCOS (OR=2.43, P=0.006, 95%CI: 1.28-2.62).
Conclusion It seems that there is a relationship between the -1301 (T/C) polymorphism of TNF-α gene
and the risk of PCOS in women. |
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| ISSN: | 1561-3666 2228-7213 |