Evolution of Superinfection Immunity in Cluster A Mycobacteriophages

ABSTRACT Temperate phages encode an immunity system to control lytic gene expression during lysogeny. This gene regulatory circuit consists of multiple interacting genetic elements, and although it is essential for controlling phage growth, it is subject to conflicting evolutionary pressures. During...

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Bibliographic Details
Main Authors: Travis N. Mavrich, Graham F. Hatfull
Format: Article
Language:English
Published: American Society for Microbiology 2019-06-01
Series:mBio
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/mBio.00971-19