Natural Polyketides Act as Promising Antifungal Agents
Invasive fungal infections present a significant risk to human health. The current arsenal of antifungal drugs is hindered by drug resistance, limited antifungal range, inadequate safety profiles, and low oral bioavailability. Consequently, there is an urgent imperative to develop novel antifungal m...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/13/11/1572 |
| _version_ | 1797460000609665024 |
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| author | Li Wang Hui Lu Yuanying Jiang |
| author_facet | Li Wang Hui Lu Yuanying Jiang |
| author_sort | Li Wang |
| collection | DOAJ |
| description | Invasive fungal infections present a significant risk to human health. The current arsenal of antifungal drugs is hindered by drug resistance, limited antifungal range, inadequate safety profiles, and low oral bioavailability. Consequently, there is an urgent imperative to develop novel antifungal medications for clinical application. This comprehensive review provides a summary of the antifungal properties and mechanisms exhibited by natural polyketides, encompassing macrolide polyethers, polyether polyketides, xanthone polyketides, linear polyketides, hybrid polyketide non-ribosomal peptides, and pyridine derivatives. Investigating natural polyketide compounds and their derivatives has demonstrated their remarkable efficacy and promising clinical application as antifungal agents. |
| first_indexed | 2024-03-09T16:59:44Z |
| format | Article |
| id | doaj.art-c73e496d2bd24637b990ab9b11aee042 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T16:59:44Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-c73e496d2bd24637b990ab9b11aee0422023-11-24T14:31:47ZengMDPI AGBiomolecules2218-273X2023-10-011311157210.3390/biom13111572Natural Polyketides Act as Promising Antifungal AgentsLi Wang0Hui Lu1Yuanying Jiang2Department of Pharmacy, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Pharmacy, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Pharmacy, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaInvasive fungal infections present a significant risk to human health. The current arsenal of antifungal drugs is hindered by drug resistance, limited antifungal range, inadequate safety profiles, and low oral bioavailability. Consequently, there is an urgent imperative to develop novel antifungal medications for clinical application. This comprehensive review provides a summary of the antifungal properties and mechanisms exhibited by natural polyketides, encompassing macrolide polyethers, polyether polyketides, xanthone polyketides, linear polyketides, hybrid polyketide non-ribosomal peptides, and pyridine derivatives. Investigating natural polyketide compounds and their derivatives has demonstrated their remarkable efficacy and promising clinical application as antifungal agents.https://www.mdpi.com/2218-273X/13/11/1572polyketidesantifungalinvasive fungal infections |
| spellingShingle | Li Wang Hui Lu Yuanying Jiang Natural Polyketides Act as Promising Antifungal Agents Biomolecules polyketides antifungal invasive fungal infections |
| title | Natural Polyketides Act as Promising Antifungal Agents |
| title_full | Natural Polyketides Act as Promising Antifungal Agents |
| title_fullStr | Natural Polyketides Act as Promising Antifungal Agents |
| title_full_unstemmed | Natural Polyketides Act as Promising Antifungal Agents |
| title_short | Natural Polyketides Act as Promising Antifungal Agents |
| title_sort | natural polyketides act as promising antifungal agents |
| topic | polyketides antifungal invasive fungal infections |
| url | https://www.mdpi.com/2218-273X/13/11/1572 |
| work_keys_str_mv | AT liwang naturalpolyketidesactaspromisingantifungalagents AT huilu naturalpolyketidesactaspromisingantifungalagents AT yuanyingjiang naturalpolyketidesactaspromisingantifungalagents |