The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications
Hemorrhagic stroke, accounting for 10–30% of stroke cases, carries high rates of morbidity and mortality. This review presents the current knowledge on the efficacy of hyperbaric oxygen (HBO)-based modalities in the preclinical research on hemorrhagic stroke. Both preconditioning and post-treatment...
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Format: | Article |
Language: | English |
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Termedia Publishing House
2017-01-01
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Series: | Archives of Medical Science |
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Online Access: | https://www.termedia.pl/The-efficacy-of-hyperbaric-oxygen-in-hemorrhagic-stroke-experimental-and-clinical-implications,19,29075,1,1.html |
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author | Robert P. Ostrowski Katarzyna Stępień Emanuela Pucko Ewa Matyja |
author_facet | Robert P. Ostrowski Katarzyna Stępień Emanuela Pucko Ewa Matyja |
author_sort | Robert P. Ostrowski |
collection | DOAJ |
description | Hemorrhagic stroke, accounting for 10–30% of stroke cases, carries high rates of morbidity and mortality. This review presents the current knowledge on the efficacy of hyperbaric oxygen (HBO)-based modalities in the preclinical research on hemorrhagic stroke. Both preconditioning and post-treatment with HBO are considered as prospective therapeutic options. High efficacy of HBO therapy (HBOT) for brain hemorrhage has been noted. We found that moderate hyperbaric pressures appear optimal for therapeutic effect, while the therapeutic window of opportunity is short. HBO preconditioning offers more modest neuroprotective benefit as compared to HBO post-treatment for experimental intracerebral hemorrhage. We advocate for mandatory calculations of percent changes in the experimentally investigated indexes of HBO effectiveness and stress the need to design new clinical trials on HBO for hemorrhagic stroke. |
first_indexed | 2024-12-19T03:45:25Z |
format | Article |
id | doaj.art-c7434216b27445a08f61d133ca00a33d |
institution | Directory Open Access Journal |
issn | 1734-1922 1896-9151 |
language | English |
last_indexed | 2024-12-19T03:45:25Z |
publishDate | 2017-01-01 |
publisher | Termedia Publishing House |
record_format | Article |
series | Archives of Medical Science |
spelling | doaj.art-c7434216b27445a08f61d133ca00a33d2022-12-21T20:37:08ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512017-01-011351217122310.5114/aoms.2017.6508129075The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implicationsRobert P. OstrowskiKatarzyna StępieńEmanuela PuckoEwa MatyjaHemorrhagic stroke, accounting for 10–30% of stroke cases, carries high rates of morbidity and mortality. This review presents the current knowledge on the efficacy of hyperbaric oxygen (HBO)-based modalities in the preclinical research on hemorrhagic stroke. Both preconditioning and post-treatment with HBO are considered as prospective therapeutic options. High efficacy of HBO therapy (HBOT) for brain hemorrhage has been noted. We found that moderate hyperbaric pressures appear optimal for therapeutic effect, while the therapeutic window of opportunity is short. HBO preconditioning offers more modest neuroprotective benefit as compared to HBO post-treatment for experimental intracerebral hemorrhage. We advocate for mandatory calculations of percent changes in the experimentally investigated indexes of HBO effectiveness and stress the need to design new clinical trials on HBO for hemorrhagic stroke.https://www.termedia.pl/The-efficacy-of-hyperbaric-oxygen-in-hemorrhagic-stroke-experimental-and-clinical-implications,19,29075,1,1.htmlintracerebral hemorrhage subarachnoid hemorrhage brain edema preclinical research |
spellingShingle | Robert P. Ostrowski Katarzyna Stępień Emanuela Pucko Ewa Matyja The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications Archives of Medical Science intracerebral hemorrhage subarachnoid hemorrhage brain edema preclinical research |
title | The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications |
title_full | The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications |
title_fullStr | The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications |
title_full_unstemmed | The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications |
title_short | The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications |
title_sort | efficacy of hyperbaric oxygen in hemorrhagic stroke experimental and clinical implications |
topic | intracerebral hemorrhage subarachnoid hemorrhage brain edema preclinical research |
url | https://www.termedia.pl/The-efficacy-of-hyperbaric-oxygen-in-hemorrhagic-stroke-experimental-and-clinical-implications,19,29075,1,1.html |
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