The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications

Hemorrhagic stroke, accounting for 10–30% of stroke cases, carries high rates of morbidity and mortality. This review presents the current knowledge on the efficacy of hyperbaric oxygen (HBO)-based modalities in the preclinical research on hemorrhagic stroke. Both preconditioning and post-treatment...

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Main Authors: Robert P. Ostrowski, Katarzyna Stępień, Emanuela Pucko, Ewa Matyja
Format: Article
Language:English
Published: Termedia Publishing House 2017-01-01
Series:Archives of Medical Science
Subjects:
Online Access:https://www.termedia.pl/The-efficacy-of-hyperbaric-oxygen-in-hemorrhagic-stroke-experimental-and-clinical-implications,19,29075,1,1.html
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author Robert P. Ostrowski
Katarzyna Stępień
Emanuela Pucko
Ewa Matyja
author_facet Robert P. Ostrowski
Katarzyna Stępień
Emanuela Pucko
Ewa Matyja
author_sort Robert P. Ostrowski
collection DOAJ
description Hemorrhagic stroke, accounting for 10–30% of stroke cases, carries high rates of morbidity and mortality. This review presents the current knowledge on the efficacy of hyperbaric oxygen (HBO)-based modalities in the preclinical research on hemorrhagic stroke. Both preconditioning and post-treatment with HBO are considered as prospective therapeutic options. High efficacy of HBO therapy (HBOT) for brain hemorrhage has been noted. We found that moderate hyperbaric pressures appear optimal for therapeutic effect, while the therapeutic window of opportunity is short. HBO preconditioning offers more modest neuroprotective benefit as compared to HBO post-treatment for experimental intracerebral hemorrhage. We advocate for mandatory calculations of percent changes in the experimentally investigated indexes of HBO effectiveness and stress the need to design new clinical trials on HBO for hemorrhagic stroke.
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spelling doaj.art-c7434216b27445a08f61d133ca00a33d2022-12-21T20:37:08ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512017-01-011351217122310.5114/aoms.2017.6508129075The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implicationsRobert P. OstrowskiKatarzyna StępieńEmanuela PuckoEwa MatyjaHemorrhagic stroke, accounting for 10–30% of stroke cases, carries high rates of morbidity and mortality. This review presents the current knowledge on the efficacy of hyperbaric oxygen (HBO)-based modalities in the preclinical research on hemorrhagic stroke. Both preconditioning and post-treatment with HBO are considered as prospective therapeutic options. High efficacy of HBO therapy (HBOT) for brain hemorrhage has been noted. We found that moderate hyperbaric pressures appear optimal for therapeutic effect, while the therapeutic window of opportunity is short. HBO preconditioning offers more modest neuroprotective benefit as compared to HBO post-treatment for experimental intracerebral hemorrhage. We advocate for mandatory calculations of percent changes in the experimentally investigated indexes of HBO effectiveness and stress the need to design new clinical trials on HBO for hemorrhagic stroke.https://www.termedia.pl/The-efficacy-of-hyperbaric-oxygen-in-hemorrhagic-stroke-experimental-and-clinical-implications,19,29075,1,1.htmlintracerebral hemorrhage subarachnoid hemorrhage brain edema preclinical research
spellingShingle Robert P. Ostrowski
Katarzyna Stępień
Emanuela Pucko
Ewa Matyja
The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications
Archives of Medical Science
intracerebral hemorrhage
subarachnoid hemorrhage
brain edema
preclinical research
title The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications
title_full The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications
title_fullStr The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications
title_full_unstemmed The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications
title_short The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications
title_sort efficacy of hyperbaric oxygen in hemorrhagic stroke experimental and clinical implications
topic intracerebral hemorrhage
subarachnoid hemorrhage
brain edema
preclinical research
url https://www.termedia.pl/The-efficacy-of-hyperbaric-oxygen-in-hemorrhagic-stroke-experimental-and-clinical-implications,19,29075,1,1.html
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