A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: <i>Staphylococcus caprae</i>, <i>Corynebacterium</i>, and <i>Cutibacterium</i> Species
Little is known about the scalp bacterial composition of alopecia areata (AA) patients. The aim of this study was to investigate the differences in the scalp microbiome of AA patients according to their prognosis, in addition to healthy controls. A total of 33 AA patients and 12 healthy controls (HC...
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MDPI AG
2022-04-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/5/864 |
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| author | Eun Jeong Won Hyun Hee Jang Hansoo Park Seong Jin Kim |
| author_facet | Eun Jeong Won Hyun Hee Jang Hansoo Park Seong Jin Kim |
| author_sort | Eun Jeong Won |
| collection | DOAJ |
| description | Little is known about the scalp bacterial composition of alopecia areata (AA) patients. The aim of this study was to investigate the differences in the scalp microbiome of AA patients according to their prognosis, in addition to healthy controls. A total of 33 AA patients and 12 healthy controls (HC) were included in this study. The microbiomes were characterized by sequencing 16S rRNA genes on the Illumina MiSeq platform. The scalp microbiome was more diverse in AA patients compared to HC, but not significantly different according to the severity of AA. Nevertheless, the higher proportion of <i>Corynebacterium</i> species and the lower proportion of <i>Staphylococcus caprae</i> among the <i>Staphylococcus</i> species were noticed in severe AA patients compared to HC or mild AA. The higher ratio of <i>Cutibacterium</i> species to <i>S. caprae</i> was noticed in severe AA. We highlight the potential predictive role of scalp microbiome profiling to a worse prognosis of patients with alopecia areata. |
| first_indexed | 2024-03-10T03:23:27Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T03:23:27Z |
| publishDate | 2022-04-01 |
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| series | Microorganisms |
| spelling | doaj.art-c745c3fdad79445fbab83575db7c6aa22023-11-23T12:14:07ZengMDPI AGMicroorganisms2076-26072022-04-0110586410.3390/microorganisms10050864A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: <i>Staphylococcus caprae</i>, <i>Corynebacterium</i>, and <i>Cutibacterium</i> SpeciesEun Jeong Won0Hyun Hee Jang1Hansoo Park2Seong Jin Kim3Department of Laboratory Medicine, Chonnam National University Hwasun Hospital, Hwasun 58128, Jeollanam-do, KoreaDepartment of Parasitology and Tropical Medicine, Chonnam National University Medical School, Hwasun 58128, Jeollanam-do, KoreaDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, KoreaDepartment of Dermatology, Chonnam National University Hospital, Gwangju 61469, KoreaLittle is known about the scalp bacterial composition of alopecia areata (AA) patients. The aim of this study was to investigate the differences in the scalp microbiome of AA patients according to their prognosis, in addition to healthy controls. A total of 33 AA patients and 12 healthy controls (HC) were included in this study. The microbiomes were characterized by sequencing 16S rRNA genes on the Illumina MiSeq platform. The scalp microbiome was more diverse in AA patients compared to HC, but not significantly different according to the severity of AA. Nevertheless, the higher proportion of <i>Corynebacterium</i> species and the lower proportion of <i>Staphylococcus caprae</i> among the <i>Staphylococcus</i> species were noticed in severe AA patients compared to HC or mild AA. The higher ratio of <i>Cutibacterium</i> species to <i>S. caprae</i> was noticed in severe AA. We highlight the potential predictive role of scalp microbiome profiling to a worse prognosis of patients with alopecia areata.https://www.mdpi.com/2076-2607/10/5/864scalp microbiomealopecia areataprognosis<i>Staphylococcus caprae</i><i>Corynebacterium</i><i>Cutibacterium</i> species |
| spellingShingle | Eun Jeong Won Hyun Hee Jang Hansoo Park Seong Jin Kim A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: <i>Staphylococcus caprae</i>, <i>Corynebacterium</i>, and <i>Cutibacterium</i> Species Microorganisms scalp microbiome alopecia areata prognosis <i>Staphylococcus caprae</i> <i>Corynebacterium</i> <i>Cutibacterium</i> species |
| title | A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: <i>Staphylococcus caprae</i>, <i>Corynebacterium</i>, and <i>Cutibacterium</i> Species |
| title_full | A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: <i>Staphylococcus caprae</i>, <i>Corynebacterium</i>, and <i>Cutibacterium</i> Species |
| title_fullStr | A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: <i>Staphylococcus caprae</i>, <i>Corynebacterium</i>, and <i>Cutibacterium</i> Species |
| title_full_unstemmed | A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: <i>Staphylococcus caprae</i>, <i>Corynebacterium</i>, and <i>Cutibacterium</i> Species |
| title_short | A Potential Predictive Role of the Scalp Microbiome Profiling in Patients with Alopecia Areata: <i>Staphylococcus caprae</i>, <i>Corynebacterium</i>, and <i>Cutibacterium</i> Species |
| title_sort | potential predictive role of the scalp microbiome profiling in patients with alopecia areata i staphylococcus caprae i i corynebacterium i and i cutibacterium i species |
| topic | scalp microbiome alopecia areata prognosis <i>Staphylococcus caprae</i> <i>Corynebacterium</i> <i>Cutibacterium</i> species |
| url | https://www.mdpi.com/2076-2607/10/5/864 |
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