Concurrent TMS-fMRI for causal network perturbation and proof of target engagement
The experimental manipulation of neural activity by neurostimulation techniques overcomes the inherent limitations of correlative recordings, enabling the researcher to investigate causal brain-behavior relationships. But only when stimulation and recordings are combined, the direct impact of the st...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-08-01
|
| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811921003700 |
| _version_ | 1819157009006592000 |
|---|---|
| author | Til Ole Bergmann Rathiga Varatheeswaran Colleen A. Hanlon Kristoffer H. Madsen Axel Thielscher Hartwig Roman Siebner |
| author_facet | Til Ole Bergmann Rathiga Varatheeswaran Colleen A. Hanlon Kristoffer H. Madsen Axel Thielscher Hartwig Roman Siebner |
| author_sort | Til Ole Bergmann |
| collection | DOAJ |
| description | The experimental manipulation of neural activity by neurostimulation techniques overcomes the inherent limitations of correlative recordings, enabling the researcher to investigate causal brain-behavior relationships. But only when stimulation and recordings are combined, the direct impact of the stimulation on neural activity can be evaluated. In humans, this can be achieved non-invasively through the concurrent combination of transcranial magnetic stimulation (TMS) with functional magnetic resonance imaging (fMRI). Concurrent TMS-fMRI allows the assessment of the neurovascular responses evoked by TMS with excellent spatial resolution and full-brain coverage. This enables the functional mapping of both local and remote network effects of TMS in cortical as well as deep subcortical structures, offering unique opportunities for basic research and clinical applications. The purpose of this review is to introduce the reader to this powerful tool. We will introduce the technical challenges and state-of-the art solutions and provide a comprehensive overview of the existing literature and the available experimental approaches. We will highlight the unique insights that can be gained from concurrent TMS-fMRI, including the state-dependent assessment of neural responsiveness and inter-regional effective connectivity, the demonstration of functional target engagement, and the systematic evaluation of stimulation parameters. We will also discuss how concurrent TMS-fMRI during a behavioral task can help to link behavioral TMS effects to changes in neural network activity and to identify peripheral co-stimulation confounds. Finally, we will review the use of concurrent TMS-fMRI for developing TMS treatments of psychiatric and neurological disorders and suggest future improvements for further advancing the application of concurrent TMS-fMRI. |
| first_indexed | 2024-12-22T16:01:56Z |
| format | Article |
| id | doaj.art-c747f4526aa94a43a1be10155fab3f50 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-22T16:01:56Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-c747f4526aa94a43a1be10155fab3f502022-12-21T18:20:41ZengElsevierNeuroImage1095-95722021-08-01237118093Concurrent TMS-fMRI for causal network perturbation and proof of target engagementTil Ole Bergmann0Rathiga Varatheeswaran1Colleen A. Hanlon2Kristoffer H. Madsen3Axel Thielscher4Hartwig Roman Siebner5Neuroimaging Center (NIC), Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University Medical Center, Langenbeckstr. 1, 55131, Mainz, Germany; Leibniz Institute for Resilience Research, Wallstraße 7-9, 55122, Mainz, Germany; Corresponding author.Neuroimaging Center (NIC), Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University Medical Center, Langenbeckstr. 1, 55131, Mainz, Germany; Leibniz Institute for Resilience Research, Wallstraße 7-9, 55122, Mainz, GermanyDepartment of Cancer Biology, Wake Forest School of Medicine, 1 Medical Center Blvd., Winston-Salem, NC 27157, USADanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Kettegård Allé 30, 2650, Hvidovre, Denmark; Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kgs. Lyngby, DenmarkDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Kettegård Allé 30, 2650, Hvidovre, Denmark; Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, DenmarkDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Kettegård Allé 30, 2650, Hvidovre, Denmark; Department of Neurology, Copenhagen University Hospital Bispebjerg, Bispebjerg Bakke 23, 2400 København NV, Denmark; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, DenmarkThe experimental manipulation of neural activity by neurostimulation techniques overcomes the inherent limitations of correlative recordings, enabling the researcher to investigate causal brain-behavior relationships. But only when stimulation and recordings are combined, the direct impact of the stimulation on neural activity can be evaluated. In humans, this can be achieved non-invasively through the concurrent combination of transcranial magnetic stimulation (TMS) with functional magnetic resonance imaging (fMRI). Concurrent TMS-fMRI allows the assessment of the neurovascular responses evoked by TMS with excellent spatial resolution and full-brain coverage. This enables the functional mapping of both local and remote network effects of TMS in cortical as well as deep subcortical structures, offering unique opportunities for basic research and clinical applications. The purpose of this review is to introduce the reader to this powerful tool. We will introduce the technical challenges and state-of-the art solutions and provide a comprehensive overview of the existing literature and the available experimental approaches. We will highlight the unique insights that can be gained from concurrent TMS-fMRI, including the state-dependent assessment of neural responsiveness and inter-regional effective connectivity, the demonstration of functional target engagement, and the systematic evaluation of stimulation parameters. We will also discuss how concurrent TMS-fMRI during a behavioral task can help to link behavioral TMS effects to changes in neural network activity and to identify peripheral co-stimulation confounds. Finally, we will review the use of concurrent TMS-fMRI for developing TMS treatments of psychiatric and neurological disorders and suggest future improvements for further advancing the application of concurrent TMS-fMRI.http://www.sciencedirect.com/science/article/pii/S1053811921003700Transcranial magnetic stimulation (TMS)Functional magnetic resonance imaging (fMRI)ConcurrentInterleavedSimultaneousReview |
| spellingShingle | Til Ole Bergmann Rathiga Varatheeswaran Colleen A. Hanlon Kristoffer H. Madsen Axel Thielscher Hartwig Roman Siebner Concurrent TMS-fMRI for causal network perturbation and proof of target engagement NeuroImage Transcranial magnetic stimulation (TMS) Functional magnetic resonance imaging (fMRI) Concurrent Interleaved Simultaneous Review |
| title | Concurrent TMS-fMRI for causal network perturbation and proof of target engagement |
| title_full | Concurrent TMS-fMRI for causal network perturbation and proof of target engagement |
| title_fullStr | Concurrent TMS-fMRI for causal network perturbation and proof of target engagement |
| title_full_unstemmed | Concurrent TMS-fMRI for causal network perturbation and proof of target engagement |
| title_short | Concurrent TMS-fMRI for causal network perturbation and proof of target engagement |
| title_sort | concurrent tms fmri for causal network perturbation and proof of target engagement |
| topic | Transcranial magnetic stimulation (TMS) Functional magnetic resonance imaging (fMRI) Concurrent Interleaved Simultaneous Review |
| url | http://www.sciencedirect.com/science/article/pii/S1053811921003700 |
| work_keys_str_mv | AT tilolebergmann concurrenttmsfmriforcausalnetworkperturbationandproofoftargetengagement AT rathigavaratheeswaran concurrenttmsfmriforcausalnetworkperturbationandproofoftargetengagement AT colleenahanlon concurrenttmsfmriforcausalnetworkperturbationandproofoftargetengagement AT kristofferhmadsen concurrenttmsfmriforcausalnetworkperturbationandproofoftargetengagement AT axelthielscher concurrenttmsfmriforcausalnetworkperturbationandproofoftargetengagement AT hartwigromansiebner concurrenttmsfmriforcausalnetworkperturbationandproofoftargetengagement |