A study on adverse drug reactions in a tertiary care hospital of Northeast India
Objective: Purpose of this study was to monitor adverse drug reactions reported from various departments of a tertiary care hospital in Northeast India. Reported adverse drug reactions were analysed for causality and severity assessment. Methods: This cross sectional study was conducted in a tertiar...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-06-01
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| Series: | Alexandria Journal of Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090506816300653 |
| _version_ | 1819294812375875584 |
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| author | Ratan J. Lihite Mangala Lahkar Sukirti Das Debeeka Hazarika Murali Kotni Mudasir Maqbool Swapna Phukan |
| author_facet | Ratan J. Lihite Mangala Lahkar Sukirti Das Debeeka Hazarika Murali Kotni Mudasir Maqbool Swapna Phukan |
| author_sort | Ratan J. Lihite |
| collection | DOAJ |
| description | Objective: Purpose of this study was to monitor adverse drug reactions reported from various departments of a tertiary care hospital in Northeast India. Reported adverse drug reactions were analysed for causality and severity assessment.
Methods: This cross sectional study was conducted in a tertiary care hospital at Guwahati, Northeast India, for 7 months. Patients of all age and either sex were included. Adverse drug reactions were reported by the physicians of this hospital and their causality and severity assessments were performed as per Naranjo’s and Hartwig’s assessment criteria respectively. Descriptive statistics were used for data analysis.
Results: Total 255 adverse drug reactions were reported from various departments of this tertiary care hospital. Most of the adverse drug reactions were observed in the age group of 21–30 year. Acne (46) was commonly reported reaction. Topical steroids, betamethasone sodium phosphate and clobetasol were reported to induce maximum number of reactions (59). Skin (227, 66.9%) was commonly affected organ system. Most of the adverse drug reactions were possible (240, 94.1%) and mild (222, 87%) in nature.
Conclusions: The topical steroid (betamethasone sodium phosphate) was reported to induce adverse drug reactions in majority of the patients. The commonly reported reaction was acne. |
| first_indexed | 2024-12-24T04:32:16Z |
| format | Article |
| id | doaj.art-c7495fbd77be45c488f0649f794e1e2c |
| institution | Directory Open Access Journal |
| issn | 2090-5068 |
| language | English |
| last_indexed | 2024-12-24T04:32:16Z |
| publishDate | 2017-06-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Alexandria Journal of Medicine |
| spelling | doaj.art-c7495fbd77be45c488f0649f794e1e2c2022-12-21T17:15:22ZengTaylor & Francis GroupAlexandria Journal of Medicine2090-50682017-06-0153215115610.1016/j.ajme.2016.05.007A study on adverse drug reactions in a tertiary care hospital of Northeast IndiaRatan J. Lihite0Mangala Lahkar1Sukirti Das2Debeeka Hazarika3Murali Kotni4Mudasir Maqbool5Swapna Phukan6ADR Monitoring Centre (Pharmacovigilance Programme of India, Indian Pharmacopoeia Commission, Ministry of Health & Family Welfare, Govt of India), Department of Pharmacology, Gauhati Medical College, Guwahati, IndiaDepartment of Pharmacology, Gauhati Medical College, Guwahati, IndiaInstitute of Pharmacy, Gauhati Medical College, Guwahati, IndiaDepartment of Dermatology & STD, Gauhati Medical College, Guwahati, IndiaDepartment of Pharmacy Practice, National Institute of Pharmaceutical Education & Research (NIPER), Guwahati, IndiaDepartment of Pharmacy Practice, National Institute of Pharmaceutical Education & Research (NIPER), Guwahati, IndiaDepartment of Pharmacology, Gauhati Medical College, Guwahati, IndiaObjective: Purpose of this study was to monitor adverse drug reactions reported from various departments of a tertiary care hospital in Northeast India. Reported adverse drug reactions were analysed for causality and severity assessment. Methods: This cross sectional study was conducted in a tertiary care hospital at Guwahati, Northeast India, for 7 months. Patients of all age and either sex were included. Adverse drug reactions were reported by the physicians of this hospital and their causality and severity assessments were performed as per Naranjo’s and Hartwig’s assessment criteria respectively. Descriptive statistics were used for data analysis. Results: Total 255 adverse drug reactions were reported from various departments of this tertiary care hospital. Most of the adverse drug reactions were observed in the age group of 21–30 year. Acne (46) was commonly reported reaction. Topical steroids, betamethasone sodium phosphate and clobetasol were reported to induce maximum number of reactions (59). Skin (227, 66.9%) was commonly affected organ system. Most of the adverse drug reactions were possible (240, 94.1%) and mild (222, 87%) in nature. Conclusions: The topical steroid (betamethasone sodium phosphate) was reported to induce adverse drug reactions in majority of the patients. The commonly reported reaction was acne.http://www.sciencedirect.com/science/article/pii/S2090506816300653ADRsNortheastNaranjoHartwigPharmacovigilance |
| spellingShingle | Ratan J. Lihite Mangala Lahkar Sukirti Das Debeeka Hazarika Murali Kotni Mudasir Maqbool Swapna Phukan A study on adverse drug reactions in a tertiary care hospital of Northeast India Alexandria Journal of Medicine ADRs Northeast Naranjo Hartwig Pharmacovigilance |
| title | A study on adverse drug reactions in a tertiary care hospital of Northeast India |
| title_full | A study on adverse drug reactions in a tertiary care hospital of Northeast India |
| title_fullStr | A study on adverse drug reactions in a tertiary care hospital of Northeast India |
| title_full_unstemmed | A study on adverse drug reactions in a tertiary care hospital of Northeast India |
| title_short | A study on adverse drug reactions in a tertiary care hospital of Northeast India |
| title_sort | study on adverse drug reactions in a tertiary care hospital of northeast india |
| topic | ADRs Northeast Naranjo Hartwig Pharmacovigilance |
| url | http://www.sciencedirect.com/science/article/pii/S2090506816300653 |
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