Impact of post-dialysis calcium level on ex vivo rat aortic wall calcification.
OBJECTIVES:Vascular calcification is a frequent complication in chronic haemodialysis patients and is associated with adverse outcomes. Serum calcium and phosphate levels and imbalances in calcification regulators are thought to contribute to the process. In this regard, the dialysate calcium concen...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5568142?pdf=render |
| _version_ | 1828491091131760640 |
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| author | Daniel Azpiazu Emilio González-Parra Alberto Ortiz Jesús Egido Ricardo Villa-Bellosta |
| author_facet | Daniel Azpiazu Emilio González-Parra Alberto Ortiz Jesús Egido Ricardo Villa-Bellosta |
| author_sort | Daniel Azpiazu |
| collection | DOAJ |
| description | OBJECTIVES:Vascular calcification is a frequent complication in chronic haemodialysis patients and is associated with adverse outcomes. Serum calcium and phosphate levels and imbalances in calcification regulators are thought to contribute to the process. In this regard, the dialysate calcium concentration is a modifiable tool for modulating the risk of vascular calcification. We explored pre- and post-dialysis phosphate and calcium concentrations in stable chronic haemodialysis patients treated by dialysis with the KDIGO-suggested 1.5 mmol/L calcium dialysate to investigate the effects on ex vivo calcification of rat aortic rings. APPROACH AND RESULTS:At the end of haemodialysis, mean serum calcium levels were increased in 88% of paired pre-/post-dialysis samples, while mean serum phosphate and parathyroid hormone levels were decreased. Rat aortic ring cultures grown at the same calcium and phosphate concentrations revealed that pre- and post-dialysis resulted in a similar degree of calcification. By contrast, haemodialysis with unchanged serum calcium resulted in a 5-fold reduction in calcium deposition. CONCLUSION:Dialysis with the widely prescribed 1.5 mmol/L calcium dose results in persistent high serum calcification potential in a sizable proportion of patients, driven by increased post-dialysis calcium concentration. This could potentially be mitigated by individualising dialysate calcium dosage based on pre-dialysis serum calcium levels. |
| first_indexed | 2024-12-11T10:56:06Z |
| format | Article |
| id | doaj.art-c74a075688da4eb2bbc642a84b31a0ef |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T10:56:06Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c74a075688da4eb2bbc642a84b31a0ef2022-12-22T01:10:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01128e018373010.1371/journal.pone.0183730Impact of post-dialysis calcium level on ex vivo rat aortic wall calcification.Daniel AzpiazuEmilio González-ParraAlberto OrtizJesús EgidoRicardo Villa-BellostaOBJECTIVES:Vascular calcification is a frequent complication in chronic haemodialysis patients and is associated with adverse outcomes. Serum calcium and phosphate levels and imbalances in calcification regulators are thought to contribute to the process. In this regard, the dialysate calcium concentration is a modifiable tool for modulating the risk of vascular calcification. We explored pre- and post-dialysis phosphate and calcium concentrations in stable chronic haemodialysis patients treated by dialysis with the KDIGO-suggested 1.5 mmol/L calcium dialysate to investigate the effects on ex vivo calcification of rat aortic rings. APPROACH AND RESULTS:At the end of haemodialysis, mean serum calcium levels were increased in 88% of paired pre-/post-dialysis samples, while mean serum phosphate and parathyroid hormone levels were decreased. Rat aortic ring cultures grown at the same calcium and phosphate concentrations revealed that pre- and post-dialysis resulted in a similar degree of calcification. By contrast, haemodialysis with unchanged serum calcium resulted in a 5-fold reduction in calcium deposition. CONCLUSION:Dialysis with the widely prescribed 1.5 mmol/L calcium dose results in persistent high serum calcification potential in a sizable proportion of patients, driven by increased post-dialysis calcium concentration. This could potentially be mitigated by individualising dialysate calcium dosage based on pre-dialysis serum calcium levels.http://europepmc.org/articles/PMC5568142?pdf=render |
| spellingShingle | Daniel Azpiazu Emilio González-Parra Alberto Ortiz Jesús Egido Ricardo Villa-Bellosta Impact of post-dialysis calcium level on ex vivo rat aortic wall calcification. PLoS ONE |
| title | Impact of post-dialysis calcium level on ex vivo rat aortic wall calcification. |
| title_full | Impact of post-dialysis calcium level on ex vivo rat aortic wall calcification. |
| title_fullStr | Impact of post-dialysis calcium level on ex vivo rat aortic wall calcification. |
| title_full_unstemmed | Impact of post-dialysis calcium level on ex vivo rat aortic wall calcification. |
| title_short | Impact of post-dialysis calcium level on ex vivo rat aortic wall calcification. |
| title_sort | impact of post dialysis calcium level on ex vivo rat aortic wall calcification |
| url | http://europepmc.org/articles/PMC5568142?pdf=render |
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