Is adjuvant hysterectomy an option after radio-chemotherapy for locally advanced cervical cancer? A review
Objective. The purpose of this paper is to review the current concepts in the literature regarding the beneficial effects of adjuvant surgery after concurrent radio-chemotherapy for locally advanced cervical cancer. Method. Research of the literature was performed using PubMed databases in order to...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Digital ProScholar Media
2018-05-01
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| Series: | Journal of Clinical and Investigative Surgery |
| Subjects: | |
| Online Access: | https://www.proscholar.org/jcis/archive/2018/31/913.pdf |
| _version_ | 1811321373120790528 |
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| author | Cornelia Nitipir Cristina Orlov Ana-Maria Popa Iulian Slavu Adrian Tulin |
| author_facet | Cornelia Nitipir Cristina Orlov Ana-Maria Popa Iulian Slavu Adrian Tulin |
| author_sort | Cornelia Nitipir |
| collection | DOAJ |
| description | Objective. The purpose of this paper is to review the current concepts in the literature regarding the beneficial effects of adjuvant surgery after concurrent radio-chemotherapy for locally advanced cervical cancer. Method. Research of the literature was performed using PubMed databases in order to find articles relevant to the central topic. The PICOS criteria were used to filter the results. The paper was then structured according to the PRISMA guideline. Results. 50 individual papers were analyzed and sorted according to their relevance for the topic. 18 were classified as relevant. There was little agreement as to how beneficial adjuvant hysterectomy is in locally advanced cervical cancer after chemoradiotherapy. Some articles concluded that patients with a total clinical response after initial treatment might have superior progression-free survival and overall survival after surgery. 2 articles underlined the importance of accurate restaging after primary treatment. The lack of benefit for surgery in patients with bulky disease or persistent adenopathies was agreed upon in all cases. Conclusions. The decision for adjuvant hysterectomy with or without lymphadenectomy is a controversial one and has to be personalized and taken in a multidisciplinary team. |
| first_indexed | 2024-04-13T13:16:35Z |
| format | Article |
| id | doaj.art-c74a47b6b7814f7595f556ff433709af |
| institution | Directory Open Access Journal |
| issn | 2559-5555 |
| language | English |
| last_indexed | 2024-04-13T13:16:35Z |
| publishDate | 2018-05-01 |
| publisher | Digital ProScholar Media |
| record_format | Article |
| series | Journal of Clinical and Investigative Surgery |
| spelling | doaj.art-c74a47b6b7814f7595f556ff433709af2022-12-22T02:45:27ZengDigital ProScholar MediaJournal of Clinical and Investigative Surgery2559-55552018-05-013191310.25083/2559.5555/31.913Is adjuvant hysterectomy an option after radio-chemotherapy for locally advanced cervical cancer? A reviewCornelia Nitipir 0Cristina Orlov 1Ana-Maria Popa 2Iulian Slavu3Adrian Tulin4Carol Davila University of Medicine and Pharmacy, Bucharest, RomaniaElias University Emergency Hospital, Department of Oncology, Bucharest, RomaniaElias University Emergency Hospital, Department of Oncology, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, Bucharest, RomaniaCarol Davila University of Medicine and Pharmacy, Bucharest, RomaniaObjective. The purpose of this paper is to review the current concepts in the literature regarding the beneficial effects of adjuvant surgery after concurrent radio-chemotherapy for locally advanced cervical cancer. Method. Research of the literature was performed using PubMed databases in order to find articles relevant to the central topic. The PICOS criteria were used to filter the results. The paper was then structured according to the PRISMA guideline. Results. 50 individual papers were analyzed and sorted according to their relevance for the topic. 18 were classified as relevant. There was little agreement as to how beneficial adjuvant hysterectomy is in locally advanced cervical cancer after chemoradiotherapy. Some articles concluded that patients with a total clinical response after initial treatment might have superior progression-free survival and overall survival after surgery. 2 articles underlined the importance of accurate restaging after primary treatment. The lack of benefit for surgery in patients with bulky disease or persistent adenopathies was agreed upon in all cases. Conclusions. The decision for adjuvant hysterectomy with or without lymphadenectomy is a controversial one and has to be personalized and taken in a multidisciplinary team.https://www.proscholar.org/jcis/archive/2018/31/913.pdfcervical canceradvanced canceradjuvant hysterectomy |
| spellingShingle | Cornelia Nitipir Cristina Orlov Ana-Maria Popa Iulian Slavu Adrian Tulin Is adjuvant hysterectomy an option after radio-chemotherapy for locally advanced cervical cancer? A review Journal of Clinical and Investigative Surgery cervical cancer advanced cancer adjuvant hysterectomy |
| title | Is adjuvant hysterectomy an option after radio-chemotherapy for locally advanced cervical cancer? A review |
| title_full | Is adjuvant hysterectomy an option after radio-chemotherapy for locally advanced cervical cancer? A review |
| title_fullStr | Is adjuvant hysterectomy an option after radio-chemotherapy for locally advanced cervical cancer? A review |
| title_full_unstemmed | Is adjuvant hysterectomy an option after radio-chemotherapy for locally advanced cervical cancer? A review |
| title_short | Is adjuvant hysterectomy an option after radio-chemotherapy for locally advanced cervical cancer? A review |
| title_sort | is adjuvant hysterectomy an option after radio chemotherapy for locally advanced cervical cancer a review |
| topic | cervical cancer advanced cancer adjuvant hysterectomy |
| url | https://www.proscholar.org/jcis/archive/2018/31/913.pdf |
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