Immunosuppression after the diagnosis of renal allograft renal cell carcinoma in two transplant recipients: Case reports and review of the literature
Renal cell carcinoma (RCC) is a common solid malignancy among renal transplant recipients. While it commonly involves the native kidneys, renal allograft RCC is increasingly being reported in renal transplant recipients. Most often, renal allograft RCCs are locally confined and nephron-sparing inter...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Indian Journal of Transplantation |
| Subjects: | |
| Online Access: | http://www.ijtonline.in/article.asp?issn=2212-0017;year=2021;volume=15;issue=1;spage=81;epage=88;aulast= |
| _version_ | 1830383108492361728 |
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| author | Joyita Bharati Parikshaa Gupta Ujjwal Gorsi Ravimohan S Mavuduru Vivek Kumar Manish Rathi Harbir Singh Kohli Raja Ramachandran |
| author_facet | Joyita Bharati Parikshaa Gupta Ujjwal Gorsi Ravimohan S Mavuduru Vivek Kumar Manish Rathi Harbir Singh Kohli Raja Ramachandran |
| author_sort | Joyita Bharati |
| collection | DOAJ |
| description | Renal cell carcinoma (RCC) is a common solid malignancy among renal transplant recipients. While it commonly involves the native kidneys, renal allograft RCC is increasingly being reported in renal transplant recipients. Most often, renal allograft RCCs are locally confined and nephron-sparing interventions are successful treatments. Immunosuppression is typically reduced in transplant recipients who develop malignancies; however, there is no consensus on the same for transplant recipients with a diagnosis of RCC. We report two cases of renal allograft RCC who were successfully managed with ablative therapy and reduction of immunosuppression. However, both the patients developed irreversible graft dysfunction and are wait-listed in the deceased donor program for the second transplant. We highlight the deficiency of evidence and the need for further studies on the aspect of immunosuppression modification after the diagnosis of RCC in transplant recipients. |
| first_indexed | 2024-12-20T10:20:20Z |
| format | Article |
| id | doaj.art-c74d59ae05304a53a77bef6eacb54e09 |
| institution | Directory Open Access Journal |
| issn | 2212-0017 2212-0025 |
| language | English |
| last_indexed | 2024-12-20T10:20:20Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Transplantation |
| spelling | doaj.art-c74d59ae05304a53a77bef6eacb54e092022-12-21T19:43:57ZengWolters Kluwer Medknow PublicationsIndian Journal of Transplantation2212-00172212-00252021-01-01151818810.4103/ijot.ijot_70_20Immunosuppression after the diagnosis of renal allograft renal cell carcinoma in two transplant recipients: Case reports and review of the literatureJoyita BharatiParikshaa GuptaUjjwal GorsiRavimohan S MavuduruVivek KumarManish RathiHarbir Singh KohliRaja RamachandranRenal cell carcinoma (RCC) is a common solid malignancy among renal transplant recipients. While it commonly involves the native kidneys, renal allograft RCC is increasingly being reported in renal transplant recipients. Most often, renal allograft RCCs are locally confined and nephron-sparing interventions are successful treatments. Immunosuppression is typically reduced in transplant recipients who develop malignancies; however, there is no consensus on the same for transplant recipients with a diagnosis of RCC. We report two cases of renal allograft RCC who were successfully managed with ablative therapy and reduction of immunosuppression. However, both the patients developed irreversible graft dysfunction and are wait-listed in the deceased donor program for the second transplant. We highlight the deficiency of evidence and the need for further studies on the aspect of immunosuppression modification after the diagnosis of RCC in transplant recipients.http://www.ijtonline.in/article.asp?issn=2212-0017;year=2021;volume=15;issue=1;spage=81;epage=88;aulast=ablative therapyallograftimmunosuppressionrenal cell carcinomarenal transplant |
| spellingShingle | Joyita Bharati Parikshaa Gupta Ujjwal Gorsi Ravimohan S Mavuduru Vivek Kumar Manish Rathi Harbir Singh Kohli Raja Ramachandran Immunosuppression after the diagnosis of renal allograft renal cell carcinoma in two transplant recipients: Case reports and review of the literature Indian Journal of Transplantation ablative therapy allograft immunosuppression renal cell carcinoma renal transplant |
| title | Immunosuppression after the diagnosis of renal allograft renal cell carcinoma in two transplant recipients: Case reports and review of the literature |
| title_full | Immunosuppression after the diagnosis of renal allograft renal cell carcinoma in two transplant recipients: Case reports and review of the literature |
| title_fullStr | Immunosuppression after the diagnosis of renal allograft renal cell carcinoma in two transplant recipients: Case reports and review of the literature |
| title_full_unstemmed | Immunosuppression after the diagnosis of renal allograft renal cell carcinoma in two transplant recipients: Case reports and review of the literature |
| title_short | Immunosuppression after the diagnosis of renal allograft renal cell carcinoma in two transplant recipients: Case reports and review of the literature |
| title_sort | immunosuppression after the diagnosis of renal allograft renal cell carcinoma in two transplant recipients case reports and review of the literature |
| topic | ablative therapy allograft immunosuppression renal cell carcinoma renal transplant |
| url | http://www.ijtonline.in/article.asp?issn=2212-0017;year=2021;volume=15;issue=1;spage=81;epage=88;aulast= |
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