Neuronal localization of C1q in preclinical Alzheimer's disease
Complement has been postulated to contribute to inflammatory reactions associated with the neuropathology of Alzheimer's disease (AD). C1q, an initial component of the complement cascade, is associated with neuritic plaques and with neurons in the hippocampus of AD brain. Here, we report the pr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2004-02-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S096999610300189X |
| _version_ | 1818673312003260416 |
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| author | Maria I Fonseca Claudia H Kawas Juan C Troncoso Andrea J Tenner |
| author_facet | Maria I Fonseca Claudia H Kawas Juan C Troncoso Andrea J Tenner |
| author_sort | Maria I Fonseca |
| collection | DOAJ |
| description | Complement has been postulated to contribute to inflammatory reactions associated with the neuropathology of Alzheimer's disease (AD). C1q, an initial component of the complement cascade, is associated with neuritic plaques and with neurons in the hippocampus of AD brain. Here, we report the presence of C1q in a cognitively intact subject, previously identified as preclinical AD. We compared in detail brain tissue of this preclinical case with a genetically related late-onset AD case. In the AD brain, C1q was typically associated with fibrillar Aβ plaques in frontal cortex and with plaques and neurons in the hippocampus. In the preclinical subject, C1q was abundantly present but it was cell-associated only, being primarily colocalized with neurons in both frontal cortex and hippocampus. However, no predominant cortical neuronal C1q localization was found in other preclinical cases or in Down's cases of different ages. Thus, it is possible that this neuronal-associated C1q reflects an early, but transient, response to injury that may modulate the progression of neurological dysfunction in AD. |
| first_indexed | 2024-12-17T07:53:47Z |
| format | Article |
| id | doaj.art-c74d7e7f23cc488aba43663903ea8220 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-17T07:53:47Z |
| publishDate | 2004-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-c74d7e7f23cc488aba43663903ea82202022-12-21T21:57:46ZengElsevierNeurobiology of Disease1095-953X2004-02-011514046Neuronal localization of C1q in preclinical Alzheimer's diseaseMaria I Fonseca0Claudia H Kawas1Juan C Troncoso2Andrea J Tenner3Department of Molecular Biology and Biochemistry, University of California Irvine, CA, USA; Neurobiology and Behavior and Neurology, University of California, Irvine, CA, USA; Departments of Pathology and Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USADepartment of Molecular Biology and Biochemistry, University of California Irvine, CA, USA; Neurobiology and Behavior and Neurology, University of California, Irvine, CA, USA; Departments of Pathology and Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USADepartment of Molecular Biology and Biochemistry, University of California Irvine, CA, USA; Neurobiology and Behavior and Neurology, University of California, Irvine, CA, USA; Departments of Pathology and Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USADepartment of Molecular Biology and Biochemistry, University of California Irvine, CA, USA; Neurobiology and Behavior and Neurology, University of California, Irvine, CA, USA; Departments of Pathology and Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USAComplement has been postulated to contribute to inflammatory reactions associated with the neuropathology of Alzheimer's disease (AD). C1q, an initial component of the complement cascade, is associated with neuritic plaques and with neurons in the hippocampus of AD brain. Here, we report the presence of C1q in a cognitively intact subject, previously identified as preclinical AD. We compared in detail brain tissue of this preclinical case with a genetically related late-onset AD case. In the AD brain, C1q was typically associated with fibrillar Aβ plaques in frontal cortex and with plaques and neurons in the hippocampus. In the preclinical subject, C1q was abundantly present but it was cell-associated only, being primarily colocalized with neurons in both frontal cortex and hippocampus. However, no predominant cortical neuronal C1q localization was found in other preclinical cases or in Down's cases of different ages. Thus, it is possible that this neuronal-associated C1q reflects an early, but transient, response to injury that may modulate the progression of neurological dysfunction in AD.http://www.sciencedirect.com/science/article/pii/S096999610300189XC1qComplementInflammationAlzheimer's diseaseNeurons |
| spellingShingle | Maria I Fonseca Claudia H Kawas Juan C Troncoso Andrea J Tenner Neuronal localization of C1q in preclinical Alzheimer's disease Neurobiology of Disease C1q Complement Inflammation Alzheimer's disease Neurons |
| title | Neuronal localization of C1q in preclinical Alzheimer's disease |
| title_full | Neuronal localization of C1q in preclinical Alzheimer's disease |
| title_fullStr | Neuronal localization of C1q in preclinical Alzheimer's disease |
| title_full_unstemmed | Neuronal localization of C1q in preclinical Alzheimer's disease |
| title_short | Neuronal localization of C1q in preclinical Alzheimer's disease |
| title_sort | neuronal localization of c1q in preclinical alzheimer s disease |
| topic | C1q Complement Inflammation Alzheimer's disease Neurons |
| url | http://www.sciencedirect.com/science/article/pii/S096999610300189X |
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