Enhanced disease susceptibility 1 and salicylic acid act redundantly to regulate resistance gene-mediated signaling.
Resistance (R) protein-associated pathways are well known to participate in defense against a variety of microbial pathogens. Salicylic acid (SA) and its associated proteinaceous signaling components, including enhanced disease susceptibility 1 (EDS1), non-race-specific disease resistance 1 (NDR1),...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-07-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2695777?pdf=render |
| _version_ | 1818852901746900992 |
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| author | Srivathsa C Venugopal Rae-Dong Jeong Mihir K Mandal Shifeng Zhu A C Chandra-Shekara Ye Xia Matthew Hersh Arnold J Stromberg DuRoy Navarre Aardra Kachroo Pradeep Kachroo |
| author_facet | Srivathsa C Venugopal Rae-Dong Jeong Mihir K Mandal Shifeng Zhu A C Chandra-Shekara Ye Xia Matthew Hersh Arnold J Stromberg DuRoy Navarre Aardra Kachroo Pradeep Kachroo |
| author_sort | Srivathsa C Venugopal |
| collection | DOAJ |
| description | Resistance (R) protein-associated pathways are well known to participate in defense against a variety of microbial pathogens. Salicylic acid (SA) and its associated proteinaceous signaling components, including enhanced disease susceptibility 1 (EDS1), non-race-specific disease resistance 1 (NDR1), phytoalexin deficient 4 (PAD4), senescence associated gene 101 (SAG101), and EDS5, have been identified as components of resistance derived from many R proteins. Here, we show that EDS1 and SA fulfill redundant functions in defense signaling mediated by R proteins, which were thought to function independent of EDS1 and/or SA. Simultaneous mutations in EDS1 and the SA-synthesizing enzyme SID2 compromised hypersensitive response and/or resistance mediated by R proteins that contain coiled coil domains at their N-terminal ends. Furthermore, the expression of R genes and the associated defense signaling induced in response to a reduction in the level of oleic acid were also suppressed by compromising SA biosynthesis in the eds1 mutant background. The functional redundancy with SA was specific to EDS1. Results presented here redefine our understanding of the roles of EDS1 and SA in plant defense. |
| first_indexed | 2024-12-19T07:28:17Z |
| format | Article |
| id | doaj.art-c74dec35454f4b01b2e0be43c644509e |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-12-19T07:28:17Z |
| publishDate | 2009-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-c74dec35454f4b01b2e0be43c644509e2022-12-21T20:30:47ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042009-07-0157e100054510.1371/journal.pgen.1000545Enhanced disease susceptibility 1 and salicylic acid act redundantly to regulate resistance gene-mediated signaling.Srivathsa C VenugopalRae-Dong JeongMihir K MandalShifeng ZhuA C Chandra-ShekaraYe XiaMatthew HershArnold J StrombergDuRoy NavarreAardra KachrooPradeep KachrooResistance (R) protein-associated pathways are well known to participate in defense against a variety of microbial pathogens. Salicylic acid (SA) and its associated proteinaceous signaling components, including enhanced disease susceptibility 1 (EDS1), non-race-specific disease resistance 1 (NDR1), phytoalexin deficient 4 (PAD4), senescence associated gene 101 (SAG101), and EDS5, have been identified as components of resistance derived from many R proteins. Here, we show that EDS1 and SA fulfill redundant functions in defense signaling mediated by R proteins, which were thought to function independent of EDS1 and/or SA. Simultaneous mutations in EDS1 and the SA-synthesizing enzyme SID2 compromised hypersensitive response and/or resistance mediated by R proteins that contain coiled coil domains at their N-terminal ends. Furthermore, the expression of R genes and the associated defense signaling induced in response to a reduction in the level of oleic acid were also suppressed by compromising SA biosynthesis in the eds1 mutant background. The functional redundancy with SA was specific to EDS1. Results presented here redefine our understanding of the roles of EDS1 and SA in plant defense.http://europepmc.org/articles/PMC2695777?pdf=render |
| spellingShingle | Srivathsa C Venugopal Rae-Dong Jeong Mihir K Mandal Shifeng Zhu A C Chandra-Shekara Ye Xia Matthew Hersh Arnold J Stromberg DuRoy Navarre Aardra Kachroo Pradeep Kachroo Enhanced disease susceptibility 1 and salicylic acid act redundantly to regulate resistance gene-mediated signaling. PLoS Genetics |
| title | Enhanced disease susceptibility 1 and salicylic acid act redundantly to regulate resistance gene-mediated signaling. |
| title_full | Enhanced disease susceptibility 1 and salicylic acid act redundantly to regulate resistance gene-mediated signaling. |
| title_fullStr | Enhanced disease susceptibility 1 and salicylic acid act redundantly to regulate resistance gene-mediated signaling. |
| title_full_unstemmed | Enhanced disease susceptibility 1 and salicylic acid act redundantly to regulate resistance gene-mediated signaling. |
| title_short | Enhanced disease susceptibility 1 and salicylic acid act redundantly to regulate resistance gene-mediated signaling. |
| title_sort | enhanced disease susceptibility 1 and salicylic acid act redundantly to regulate resistance gene mediated signaling |
| url | http://europepmc.org/articles/PMC2695777?pdf=render |
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