Noninvasive markers for esophageal varices in children with cirrhosis
Background The diagnosis of esophageal varices (EV) is based on the findings of esophagogastroduodenoscopy (EGD), biopsy, and serum markers. Thus, noninvasive cost-effective tests through which high-risk EV children can be diagnosed are needed. Purpose This cross-sectional study aimed to identify th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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The Korean Pediatric Society
2021-01-01
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| Series: | Clinical and Experimental Pediatrics |
| Subjects: | |
| Online Access: | http://www.e-cep.org/upload/pdf/cep-2019-01599.pdf |
| _version_ | 1818964880636510208 |
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| author | Parisa Rahmani Fatemeh Farahmand Ghobad Heidari Azadeh Sayarifard |
| author_facet | Parisa Rahmani Fatemeh Farahmand Ghobad Heidari Azadeh Sayarifard |
| author_sort | Parisa Rahmani |
| collection | DOAJ |
| description | Background The diagnosis of esophageal varices (EV) is based on the findings of esophagogastroduodenoscopy (EGD), biopsy, and serum markers. Thus, noninvasive cost-effective tests through which high-risk EV children can be diagnosed are needed. Purpose This cross-sectional study aimed to identify the noninvasive markers for EV in children with liver cirrhosis. Methods A total of 98 children with liver cirrhosis were evaluated in this study. The spleen size, platelet count, serum albumin, liver function test results, and risk scores were evaluated prior to endoscopy. The endoscopic investigations aimed to identify the presence of EV and red signs, and determine varices sizes. Results Endoscopy revealed varices in 43 subjects (43.9%). The spleen size, platelet count, international normalized ratio, aspartate aminotransferase to platelet ratio index (APRI), platelet count to spleen size ratio, and risk score differed significantly between patients with and without EV on univariate analysis; however, the logistic regression analysis showed no differences, indicating that none of these parameters were independently associated with the presence of EV. Conclusion Platelet count, risk score, platelet count to spleen size, and APRI can be useful tools for the identification of high-risk patients with EV and might reduce the need for invasive methods like EGD. |
| first_indexed | 2024-12-20T13:08:09Z |
| format | Article |
| id | doaj.art-c74efd012bd84f1e98e837e5cd96f603 |
| institution | Directory Open Access Journal |
| issn | 2713-4148 |
| language | English |
| last_indexed | 2024-12-20T13:08:09Z |
| publishDate | 2021-01-01 |
| publisher | The Korean Pediatric Society |
| record_format | Article |
| series | Clinical and Experimental Pediatrics |
| spelling | doaj.art-c74efd012bd84f1e98e837e5cd96f6032022-12-21T19:39:44ZengThe Korean Pediatric SocietyClinical and Experimental Pediatrics2713-41482021-01-01641313610.3345/cep.2019.0159920125555338Noninvasive markers for esophageal varices in children with cirrhosisParisa Rahmani0Fatemeh Farahmand1Ghobad Heidari2Azadeh Sayarifard3 Pediatric Gastroenterology and Hepatology Research Center, Tehran University of Medical Sciences, Tehran, Iran Pediatric Gastroenterology and Hepatology Research Center, Tehran University of Medical Sciences, Tehran, Iran Department of Pediatrics, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, IranBackground The diagnosis of esophageal varices (EV) is based on the findings of esophagogastroduodenoscopy (EGD), biopsy, and serum markers. Thus, noninvasive cost-effective tests through which high-risk EV children can be diagnosed are needed. Purpose This cross-sectional study aimed to identify the noninvasive markers for EV in children with liver cirrhosis. Methods A total of 98 children with liver cirrhosis were evaluated in this study. The spleen size, platelet count, serum albumin, liver function test results, and risk scores were evaluated prior to endoscopy. The endoscopic investigations aimed to identify the presence of EV and red signs, and determine varices sizes. Results Endoscopy revealed varices in 43 subjects (43.9%). The spleen size, platelet count, international normalized ratio, aspartate aminotransferase to platelet ratio index (APRI), platelet count to spleen size ratio, and risk score differed significantly between patients with and without EV on univariate analysis; however, the logistic regression analysis showed no differences, indicating that none of these parameters were independently associated with the presence of EV. Conclusion Platelet count, risk score, platelet count to spleen size, and APRI can be useful tools for the identification of high-risk patients with EV and might reduce the need for invasive methods like EGD.http://www.e-cep.org/upload/pdf/cep-2019-01599.pdfportal hypertensiongastroesophageal varicesliver cirrhosispediatricsgastrointestinal endoscopy |
| spellingShingle | Parisa Rahmani Fatemeh Farahmand Ghobad Heidari Azadeh Sayarifard Noninvasive markers for esophageal varices in children with cirrhosis Clinical and Experimental Pediatrics portal hypertension gastroesophageal varices liver cirrhosis pediatrics gastrointestinal endoscopy |
| title | Noninvasive markers for esophageal varices in children with cirrhosis |
| title_full | Noninvasive markers for esophageal varices in children with cirrhosis |
| title_fullStr | Noninvasive markers for esophageal varices in children with cirrhosis |
| title_full_unstemmed | Noninvasive markers for esophageal varices in children with cirrhosis |
| title_short | Noninvasive markers for esophageal varices in children with cirrhosis |
| title_sort | noninvasive markers for esophageal varices in children with cirrhosis |
| topic | portal hypertension gastroesophageal varices liver cirrhosis pediatrics gastrointestinal endoscopy |
| url | http://www.e-cep.org/upload/pdf/cep-2019-01599.pdf |
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