ROR1 and BMI-1 proteins as potential predictors of the effectiveness of hormone therapy in luminal breast cancer
The purpose of the study was to generalize information regarding the molecular and biological mechanisms involved in the resistance to endocrine therapy with aromatase inhibitors in patients with luminal breast cancer. Material and Methods. The literature search was conducted using Medline, Cochrane...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2022-06-01
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| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/2171 |
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| author | V. O. Tarakanova N. V. Krakhmal S. V. Patalyak M. N. Tarasov N. N. Babyshkina S. V. Vtorushin |
| author_facet | V. O. Tarakanova N. V. Krakhmal S. V. Patalyak M. N. Tarasov N. N. Babyshkina S. V. Vtorushin |
| author_sort | V. O. Tarakanova |
| collection | DOAJ |
| description | The purpose of the study was to generalize information regarding the molecular and biological mechanisms involved in the resistance to endocrine therapy with aromatase inhibitors in patients with luminal breast cancer. Material and Methods. The literature search was conducted using Medline, Cochrane Library, Elibrary and PubMed databases. Results. The review highlights the results of international studies on molecular and biological characteristics of breast tumors and their relationship with the effectiveness of hormone therapy. Particular attention was paid to the description of modern studies on ROR1 and BMI-1 proteins and their contribution to the development of tumor resistance to treatment. Conclusion. The analysis of the world literature confrms the relevance of studying the molecular and genetic characteristics of tumor tissue in patients with luminal breast cancer. The data obtained were compared to the clinical course and response to hormone therapy in order to standardize them for implementation in everyday practice as the “gold standard of diagnosis”. |
| first_indexed | 2024-04-10T01:52:34Z |
| format | Article |
| id | doaj.art-c75282a90556411dac8686789a5ea9a0 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2025-03-14T10:08:07Z |
| publishDate | 2022-06-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-c75282a90556411dac8686789a5ea9a02025-03-02T11:16:16ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682022-06-0121313514210.21294/1814-4861-2022-21-3-135-1421006ROR1 and BMI-1 proteins as potential predictors of the effectiveness of hormone therapy in luminal breast cancerV. O. Tarakanova0N. V. Krakhmal1S. V. Patalyak2M. N. Tarasov3N. N. Babyshkina4S. V. Vtorushin5Cancer Research Institute, Тomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University of the Ministry of Health of RussiaCancer Research Institute, Тomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University of the Ministry of Health of RussiaCancer Research Institute, Тomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University of the Ministry of Health of RussiaSiberian State Medical University of the Ministry of Health of RussiaCancer Research Institute, Тomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University of the Ministry of Health of RussiaCancer Research Institute, Тomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University of the Ministry of Health of RussiaThe purpose of the study was to generalize information regarding the molecular and biological mechanisms involved in the resistance to endocrine therapy with aromatase inhibitors in patients with luminal breast cancer. Material and Methods. The literature search was conducted using Medline, Cochrane Library, Elibrary and PubMed databases. Results. The review highlights the results of international studies on molecular and biological characteristics of breast tumors and their relationship with the effectiveness of hormone therapy. Particular attention was paid to the description of modern studies on ROR1 and BMI-1 proteins and their contribution to the development of tumor resistance to treatment. Conclusion. The analysis of the world literature confrms the relevance of studying the molecular and genetic characteristics of tumor tissue in patients with luminal breast cancer. The data obtained were compared to the clinical course and response to hormone therapy in order to standardize them for implementation in everyday practice as the “gold standard of diagnosis”.https://www.siboncoj.ru/jour/article/view/2171breast cancerluminal subtypesror1bmi-1adjuvant hormone therapy |
| spellingShingle | V. O. Tarakanova N. V. Krakhmal S. V. Patalyak M. N. Tarasov N. N. Babyshkina S. V. Vtorushin ROR1 and BMI-1 proteins as potential predictors of the effectiveness of hormone therapy in luminal breast cancer Сибирский онкологический журнал breast cancer luminal subtypes ror1 bmi-1 adjuvant hormone therapy |
| title | ROR1 and BMI-1 proteins as potential predictors of the effectiveness of hormone therapy in luminal breast cancer |
| title_full | ROR1 and BMI-1 proteins as potential predictors of the effectiveness of hormone therapy in luminal breast cancer |
| title_fullStr | ROR1 and BMI-1 proteins as potential predictors of the effectiveness of hormone therapy in luminal breast cancer |
| title_full_unstemmed | ROR1 and BMI-1 proteins as potential predictors of the effectiveness of hormone therapy in luminal breast cancer |
| title_short | ROR1 and BMI-1 proteins as potential predictors of the effectiveness of hormone therapy in luminal breast cancer |
| title_sort | ror1 and bmi 1 proteins as potential predictors of the effectiveness of hormone therapy in luminal breast cancer |
| topic | breast cancer luminal subtypes ror1 bmi-1 adjuvant hormone therapy |
| url | https://www.siboncoj.ru/jour/article/view/2171 |
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