Impact of Partitioning in Short-Term Food Contact Applications Focused on Polymers in Support of Migration Modelling and Exposure Risk Assessment
Food contact materials (FCMs) can transfer chemicals arising from their manufacture to food before consumption. Regulatory frameworks ensure consumer safety by prescribing methods for the assessment of FCMs that rely on migration testing either into real-life foods or food simulants. Standard migrat...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/1/121 |
| _version_ | 1797498280250179584 |
|---|---|
| author | Rainer Brandsch Mark Pemberton Dieter Schuster Frank Welle |
| author_facet | Rainer Brandsch Mark Pemberton Dieter Schuster Frank Welle |
| author_sort | Rainer Brandsch |
| collection | DOAJ |
| description | Food contact materials (FCMs) can transfer chemicals arising from their manufacture to food before consumption. Regulatory frameworks ensure consumer safety by prescribing methods for the assessment of FCMs that rely on migration testing either into real-life foods or food simulants. Standard migration testing conditions for single-use FCMs are justifiably conservative, employing recognized worst-case contact times and temperatures. For repeated-use FCMs, the third of three consecutive tests using worst-case conditions is taken as a surrogate of the much shorter contact period that often occurs over the service life of these items. Food contact regulations allow for the use of migration modelling for the chemicals in the FCM and for the partitioning that occurs between the FCM and food/simulant during prolonged contact, under which steady-state conditions are favored. This study demonstrates that the steady-state is rarely reached under repeated-use conditions and that partitioning plays a minor role that results in migration essentially being diffusion controlled. Domains of use have been identified within which partitioning does not play a significant role, allowing modelling based upon diffusion parameters to be used. These findings have the potential to advance the modelling of migration from repeated-use articles for the benefit of regulatory guidance and compliance practices. |
| first_indexed | 2024-03-10T03:31:12Z |
| format | Article |
| id | doaj.art-c7542c7fb58547cea573bdb48299c143 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:31:12Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c7542c7fb58547cea573bdb48299c1432023-11-23T11:57:05ZengMDPI AGMolecules1420-30492021-12-0127112110.3390/molecules27010121Impact of Partitioning in Short-Term Food Contact Applications Focused on Polymers in Support of Migration Modelling and Exposure Risk AssessmentRainer Brandsch0Mark Pemberton1Dieter Schuster2Frank Welle3SAFE+ Algorithmics GmbH, Untere Läng 8c, 82205 Gilching, GermanySystox Limited, Sutton Grange, Parvey Lane, Sutton, Cheshire SK11 0HX, UKSAFE+ Algorithmics GmbH, Untere Läng 8c, 82205 Gilching, GermanyFraunhofer Institute for Process Engineering and Packaging (IVV), Giggenhauser Straße 35, 85354 Freising, GermanyFood contact materials (FCMs) can transfer chemicals arising from their manufacture to food before consumption. Regulatory frameworks ensure consumer safety by prescribing methods for the assessment of FCMs that rely on migration testing either into real-life foods or food simulants. Standard migration testing conditions for single-use FCMs are justifiably conservative, employing recognized worst-case contact times and temperatures. For repeated-use FCMs, the third of three consecutive tests using worst-case conditions is taken as a surrogate of the much shorter contact period that often occurs over the service life of these items. Food contact regulations allow for the use of migration modelling for the chemicals in the FCM and for the partitioning that occurs between the FCM and food/simulant during prolonged contact, under which steady-state conditions are favored. This study demonstrates that the steady-state is rarely reached under repeated-use conditions and that partitioning plays a minor role that results in migration essentially being diffusion controlled. Domains of use have been identified within which partitioning does not play a significant role, allowing modelling based upon diffusion parameters to be used. These findings have the potential to advance the modelling of migration from repeated-use articles for the benefit of regulatory guidance and compliance practices.https://www.mdpi.com/1420-3049/27/1/121food packagingfood contact materialrepeated usemigration kineticstheory and diffusion modelling |
| spellingShingle | Rainer Brandsch Mark Pemberton Dieter Schuster Frank Welle Impact of Partitioning in Short-Term Food Contact Applications Focused on Polymers in Support of Migration Modelling and Exposure Risk Assessment Molecules food packaging food contact material repeated use migration kinetics theory and diffusion modelling |
| title | Impact of Partitioning in Short-Term Food Contact Applications Focused on Polymers in Support of Migration Modelling and Exposure Risk Assessment |
| title_full | Impact of Partitioning in Short-Term Food Contact Applications Focused on Polymers in Support of Migration Modelling and Exposure Risk Assessment |
| title_fullStr | Impact of Partitioning in Short-Term Food Contact Applications Focused on Polymers in Support of Migration Modelling and Exposure Risk Assessment |
| title_full_unstemmed | Impact of Partitioning in Short-Term Food Contact Applications Focused on Polymers in Support of Migration Modelling and Exposure Risk Assessment |
| title_short | Impact of Partitioning in Short-Term Food Contact Applications Focused on Polymers in Support of Migration Modelling and Exposure Risk Assessment |
| title_sort | impact of partitioning in short term food contact applications focused on polymers in support of migration modelling and exposure risk assessment |
| topic | food packaging food contact material repeated use migration kinetics theory and diffusion modelling |
| url | https://www.mdpi.com/1420-3049/27/1/121 |
| work_keys_str_mv | AT rainerbrandsch impactofpartitioninginshorttermfoodcontactapplicationsfocusedonpolymersinsupportofmigrationmodellingandexposureriskassessment AT markpemberton impactofpartitioninginshorttermfoodcontactapplicationsfocusedonpolymersinsupportofmigrationmodellingandexposureriskassessment AT dieterschuster impactofpartitioninginshorttermfoodcontactapplicationsfocusedonpolymersinsupportofmigrationmodellingandexposureriskassessment AT frankwelle impactofpartitioninginshorttermfoodcontactapplicationsfocusedonpolymersinsupportofmigrationmodellingandexposureriskassessment |