YC-1 induces G0/G1 phase arrest and mitochondria-dependent apoptosis in cisplatin-resistant human oral cancer CAR cells

YC-1 induces G0/G1 phase arrest and mitochondria-dependent apoptosis in cisplatin-resistant human oral cancer CAR cells

Oral cancer is a serious and fatal disease. Cisplatin is the first line of chemotherapeutic agent for oral cancer therapy. However, the development of drug resistance and severe side effects cause tremendous problems clinically. In this study, we investigated the pharmacologic mechanisms of YC-1 on...

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Bibliographic Details
Main Authors: Lee Miau-Rong, Lin Chingju, Lu Chi-Cheng, Kuo Sheng-Chu, Tsao Je-Wei, Juan Yu-Ning, Chiu Hong-Yi, Lee Fang-Yu, Yang Jai-Sing, Tsai Fuu-Jen
Format: Article
Language:English
Published: China Medical University 2017-06-01
Series:BioMedicine
Subjects:
YC-1
G0/G1 phase arrest
mitochondria
Apoptosis
CAR cells
Online Access:https://doi.org/10.1051/bmdcn/2017070205

Internet

https://doi.org/10.1051/bmdcn/2017070205

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