PB2358: PHASE 1-2 STUDY OF THE SAFETY, PK, PD, AND PRELIMINARY ACTIVITY OF TOLINAPANT IN COMBINATION WITH ORAL DECITABINE/CEDAZURIDINE AND ORAL DECITABINE/CEDAZURIDINE ALONE IN SUBJECTS WITH R/R PTCL
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-08-01
|
| Series: | HemaSphere |
| Online Access: | http://journals.lww.com/10.1097/01.HS9.0000976148.07947.e7 |
| _version_ | 1797281571857760256 |
|---|---|
| author | Jake Shortt Brian Poligone Vincent Ribrag Pier Luigi Zinzani Dima El-Sharkawi Jan Walewski Anca Prica Laksmi Wilson Sonia Souza Harold Keer Jason Taylor Enrica Marchi |
| author_facet | Jake Shortt Brian Poligone Vincent Ribrag Pier Luigi Zinzani Dima El-Sharkawi Jan Walewski Anca Prica Laksmi Wilson Sonia Souza Harold Keer Jason Taylor Enrica Marchi |
| author_sort | Jake Shortt |
| collection | DOAJ |
| first_indexed | 2024-03-07T16:59:20Z |
| format | Article |
| id | doaj.art-c7565cf856fb48a590bbc2729f8d6fef |
| institution | Directory Open Access Journal |
| issn | 2572-9241 |
| language | English |
| last_indexed | 2024-03-07T16:59:20Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | HemaSphere |
| spelling | doaj.art-c7565cf856fb48a590bbc2729f8d6fef2024-03-03T03:25:48ZengWileyHemaSphere2572-92412023-08-017e07947e710.1097/01.HS9.0000976148.07947.e7202308003-02211PB2358: PHASE 1-2 STUDY OF THE SAFETY, PK, PD, AND PRELIMINARY ACTIVITY OF TOLINAPANT IN COMBINATION WITH ORAL DECITABINE/CEDAZURIDINE AND ORAL DECITABINE/CEDAZURIDINE ALONE IN SUBJECTS WITH R/R PTCLJake Shortt0Brian Poligone1Vincent Ribrag2Pier Luigi Zinzani3Dima El-Sharkawi4Jan Walewski5Anca Prica6Laksmi Wilson7Sonia Souza8Harold Keer9Jason Taylor10Enrica Marchi111 Monash University and Monash Health, Clayton, Victoria, Australia2 Rochester Skin Lymphoma Medical Group, PLLC, Fairport, United States3 Institute of Hematology “Seràgnoli” University of Bologna Italy, Villejuif, France4 Institute of Hematology “Seràgnoli”, University of Bologna, Bologna, Italy5 The Royal Marsden NHS Foundation Trust, Surrey, United Kingdom6 Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie Państwowy Instytut Badawczy, Warszawa, Poland7 Princess Margaret Cancer Centre, Toronto, Ontario, Canada8 Astex Pharmaceuticals, Inc., Pleasanton, United States8 Astex Pharmaceuticals, Inc., Pleasanton, United States8 Astex Pharmaceuticals, Inc., Pleasanton, United States8 Astex Pharmaceuticals, Inc., Pleasanton, United States9 Emily Couric Clinical Cancer Center, University of Virginia, Charlottsville, United Stateshttp://journals.lww.com/10.1097/01.HS9.0000976148.07947.e7 |
| spellingShingle | Jake Shortt Brian Poligone Vincent Ribrag Pier Luigi Zinzani Dima El-Sharkawi Jan Walewski Anca Prica Laksmi Wilson Sonia Souza Harold Keer Jason Taylor Enrica Marchi PB2358: PHASE 1-2 STUDY OF THE SAFETY, PK, PD, AND PRELIMINARY ACTIVITY OF TOLINAPANT IN COMBINATION WITH ORAL DECITABINE/CEDAZURIDINE AND ORAL DECITABINE/CEDAZURIDINE ALONE IN SUBJECTS WITH R/R PTCL HemaSphere |
| title | PB2358: PHASE 1-2 STUDY OF THE SAFETY, PK, PD, AND PRELIMINARY ACTIVITY OF TOLINAPANT IN COMBINATION WITH ORAL DECITABINE/CEDAZURIDINE AND ORAL DECITABINE/CEDAZURIDINE ALONE IN SUBJECTS WITH R/R PTCL |
| title_full | PB2358: PHASE 1-2 STUDY OF THE SAFETY, PK, PD, AND PRELIMINARY ACTIVITY OF TOLINAPANT IN COMBINATION WITH ORAL DECITABINE/CEDAZURIDINE AND ORAL DECITABINE/CEDAZURIDINE ALONE IN SUBJECTS WITH R/R PTCL |
| title_fullStr | PB2358: PHASE 1-2 STUDY OF THE SAFETY, PK, PD, AND PRELIMINARY ACTIVITY OF TOLINAPANT IN COMBINATION WITH ORAL DECITABINE/CEDAZURIDINE AND ORAL DECITABINE/CEDAZURIDINE ALONE IN SUBJECTS WITH R/R PTCL |
| title_full_unstemmed | PB2358: PHASE 1-2 STUDY OF THE SAFETY, PK, PD, AND PRELIMINARY ACTIVITY OF TOLINAPANT IN COMBINATION WITH ORAL DECITABINE/CEDAZURIDINE AND ORAL DECITABINE/CEDAZURIDINE ALONE IN SUBJECTS WITH R/R PTCL |
| title_short | PB2358: PHASE 1-2 STUDY OF THE SAFETY, PK, PD, AND PRELIMINARY ACTIVITY OF TOLINAPANT IN COMBINATION WITH ORAL DECITABINE/CEDAZURIDINE AND ORAL DECITABINE/CEDAZURIDINE ALONE IN SUBJECTS WITH R/R PTCL |
| title_sort | pb2358 phase 1 2 study of the safety pk pd and preliminary activity of tolinapant in combination with oral decitabine cedazuridine and oral decitabine cedazuridine alone in subjects with r r ptcl |
| url | http://journals.lww.com/10.1097/01.HS9.0000976148.07947.e7 |
| work_keys_str_mv | AT jakeshortt pb2358phase12studyofthesafetypkpdandpreliminaryactivityoftolinapantincombinationwithoraldecitabinecedazuridineandoraldecitabinecedazuridinealoneinsubjectswithrrptcl AT brianpoligone pb2358phase12studyofthesafetypkpdandpreliminaryactivityoftolinapantincombinationwithoraldecitabinecedazuridineandoraldecitabinecedazuridinealoneinsubjectswithrrptcl AT vincentribrag pb2358phase12studyofthesafetypkpdandpreliminaryactivityoftolinapantincombinationwithoraldecitabinecedazuridineandoraldecitabinecedazuridinealoneinsubjectswithrrptcl AT pierluigizinzani pb2358phase12studyofthesafetypkpdandpreliminaryactivityoftolinapantincombinationwithoraldecitabinecedazuridineandoraldecitabinecedazuridinealoneinsubjectswithrrptcl AT dimaelsharkawi pb2358phase12studyofthesafetypkpdandpreliminaryactivityoftolinapantincombinationwithoraldecitabinecedazuridineandoraldecitabinecedazuridinealoneinsubjectswithrrptcl AT janwalewski pb2358phase12studyofthesafetypkpdandpreliminaryactivityoftolinapantincombinationwithoraldecitabinecedazuridineandoraldecitabinecedazuridinealoneinsubjectswithrrptcl AT ancaprica pb2358phase12studyofthesafetypkpdandpreliminaryactivityoftolinapantincombinationwithoraldecitabinecedazuridineandoraldecitabinecedazuridinealoneinsubjectswithrrptcl AT laksmiwilson pb2358phase12studyofthesafetypkpdandpreliminaryactivityoftolinapantincombinationwithoraldecitabinecedazuridineandoraldecitabinecedazuridinealoneinsubjectswithrrptcl AT soniasouza pb2358phase12studyofthesafetypkpdandpreliminaryactivityoftolinapantincombinationwithoraldecitabinecedazuridineandoraldecitabinecedazuridinealoneinsubjectswithrrptcl AT haroldkeer pb2358phase12studyofthesafetypkpdandpreliminaryactivityoftolinapantincombinationwithoraldecitabinecedazuridineandoraldecitabinecedazuridinealoneinsubjectswithrrptcl AT jasontaylor pb2358phase12studyofthesafetypkpdandpreliminaryactivityoftolinapantincombinationwithoraldecitabinecedazuridineandoraldecitabinecedazuridinealoneinsubjectswithrrptcl AT enricamarchi pb2358phase12studyofthesafetypkpdandpreliminaryactivityoftolinapantincombinationwithoraldecitabinecedazuridineandoraldecitabinecedazuridinealoneinsubjectswithrrptcl |