A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound

A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound

A novel sprayable adhesive is established (ZnMet-PF127) by the combination of a thermosensitive hydrogel (Pluronic F127, PF127) and a coordination complex of zinc and metformin (ZnMet). Here we demonstrate that ZnMet-PF127 potently promotes the healing of traumatic skin defect and burn skin injury b...

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Bibliographic Details
Main Authors: Zhengwei Liu, Wanze Tang, Jiayi Liu, Yingying Han, Qinnan Yan, Yuechao Dong, Xiaomei Liu, Dazhi Yang, Guixing Ma, Huiling Cao
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-02-01
Series:Bioactive Materials
Subjects:
Thermosensitive hydrogel
Skin wound
ZnMet-PF127
Reactive oxygen species (ROS)
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X22002742

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