Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapy

Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapy

Adoptive cell therapy based on chimeric antigen receptor (CAR)-engineered T-cells has proven to be lifesaving for many cancer patients. However, its therapeutic efficacy has so far been restricted to only a few malignancies, with solid tumors proving to be especially recalcitrant to efficient therap...

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Bibliographic Details
Main Authors: Shipra Das, Julien Valton, Philippe Duchateau, Laurent Poirot
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
immunotherapy
CAR T-cells
allogeneic
TALEN gene editing
solid tumors
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1172681/full

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