Three-Dimensional Amide Proton Transfer-Weighted Imaging for Differentiating between Glioblastoma, IDH-Wildtype and Primary Central Nervous System Lymphoma
Distinguishing primary central nervous system lymphoma (PCNSL) from glioblastoma, isocitrate dehydrogenase (IDH)-wildtype is sometimes hard. Because the role of operation on them varies, accurate preoperative diagnosis is crucial. In this study, we evaluated whether a specific kind of chemical excha...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/3/952 |
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| author | Shigeo Ohba Kazuhiro Murayama Takao Teranishi Masanobu Kumon Shunsuke Nakae Masao Yui Kaori Yamamoto Seiji Yamada Masato Abe Mitsuhiro Hasegawa Yuichi Hirose |
| author_facet | Shigeo Ohba Kazuhiro Murayama Takao Teranishi Masanobu Kumon Shunsuke Nakae Masao Yui Kaori Yamamoto Seiji Yamada Masato Abe Mitsuhiro Hasegawa Yuichi Hirose |
| author_sort | Shigeo Ohba |
| collection | DOAJ |
| description | Distinguishing primary central nervous system lymphoma (PCNSL) from glioblastoma, isocitrate dehydrogenase (IDH)-wildtype is sometimes hard. Because the role of operation on them varies, accurate preoperative diagnosis is crucial. In this study, we evaluated whether a specific kind of chemical exchange saturation transfer imaging, i.e., amide proton transfer-weighted (APTw) imaging, was useful to distinguish PCNSL from glioblastoma, IDH-wildtype. A total of 14 PCNSL and 27 glioblastoma, IDH-wildtype cases were evaluated. There was no significant difference in the mean APTw signal values between the two groups. However, the percentile values from the 1st percentile to the 20th percentile APTw signals and the width<sub>1–100</sub> APTw signals significantly differed. The highest area under the curve was 0.796, which was obtained from the width<sub>1–100</sub> APTw signal values. The sensitivity and specificity values were 64.3% and 88.9%, respectively. APTw imaging was useful to distinguish PCNSL from glioblastoma, IDH-wildtype. To avoid unnecessary aggressive surgical resection, APTw imaging is recommended for cases in which PCNSL is one of the differential diagnoses. |
| first_indexed | 2024-03-11T09:50:26Z |
| format | Article |
| id | doaj.art-c758ead28cdb4beaa1858522d6fea754 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:50:26Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-c758ead28cdb4beaa1858522d6fea7542023-11-16T16:19:35ZengMDPI AGCancers2072-66942023-02-0115395210.3390/cancers15030952Three-Dimensional Amide Proton Transfer-Weighted Imaging for Differentiating between Glioblastoma, IDH-Wildtype and Primary Central Nervous System LymphomaShigeo Ohba0Kazuhiro Murayama1Takao Teranishi2Masanobu Kumon3Shunsuke Nakae4Masao Yui5Kaori Yamamoto6Seiji Yamada7Masato Abe8Mitsuhiro Hasegawa9Yuichi Hirose10Department of Neurosurgery, Fujita Health University School of Medicine, Toyoake 470-1192, Aichi, JapanDepartment of Radiology, Fujita Health University School of Medicine, Toyoake 470-1192, Aichi, JapanDepartment of Neurosurgery, Fujita Health University School of Medicine, Toyoake 470-1192, Aichi, JapanDepartment of Neurosurgery, Fujita Health University School of Medicine, Toyoake 470-1192, Aichi, JapanDepartment of Neurosurgery, Fujita Health University School of Medicine, Toyoake 470-1192, Aichi, JapanCanon Medical Systems Corporation, Otawara 324-8550, Tochigi, JapanCanon Medical Systems Corporation, Otawara 324-8550, Tochigi, JapanDepartment of Diagnostic Pathology, Fujita Health University School of Medicine, Toyoake 470-1192, Aichi, JapanDepartment of Pathology, Fujita Health University School of Health Sciences, Toyoake 470-1192, Aichi, JapanDepartment of Neurosurgery, Fujita Health University School of Medicine, Toyoake 470-1192, Aichi, JapanDepartment of Neurosurgery, Fujita Health University School of Medicine, Toyoake 470-1192, Aichi, JapanDistinguishing primary central nervous system lymphoma (PCNSL) from glioblastoma, isocitrate dehydrogenase (IDH)-wildtype is sometimes hard. Because the role of operation on them varies, accurate preoperative diagnosis is crucial. In this study, we evaluated whether a specific kind of chemical exchange saturation transfer imaging, i.e., amide proton transfer-weighted (APTw) imaging, was useful to distinguish PCNSL from glioblastoma, IDH-wildtype. A total of 14 PCNSL and 27 glioblastoma, IDH-wildtype cases were evaluated. There was no significant difference in the mean APTw signal values between the two groups. However, the percentile values from the 1st percentile to the 20th percentile APTw signals and the width<sub>1–100</sub> APTw signals significantly differed. The highest area under the curve was 0.796, which was obtained from the width<sub>1–100</sub> APTw signal values. The sensitivity and specificity values were 64.3% and 88.9%, respectively. APTw imaging was useful to distinguish PCNSL from glioblastoma, IDH-wildtype. To avoid unnecessary aggressive surgical resection, APTw imaging is recommended for cases in which PCNSL is one of the differential diagnoses.https://www.mdpi.com/2072-6694/15/3/952APTwCESTglioblastomaMIB-1 indexPCNSL |
| spellingShingle | Shigeo Ohba Kazuhiro Murayama Takao Teranishi Masanobu Kumon Shunsuke Nakae Masao Yui Kaori Yamamoto Seiji Yamada Masato Abe Mitsuhiro Hasegawa Yuichi Hirose Three-Dimensional Amide Proton Transfer-Weighted Imaging for Differentiating between Glioblastoma, IDH-Wildtype and Primary Central Nervous System Lymphoma Cancers APTw CEST glioblastoma MIB-1 index PCNSL |
| title | Three-Dimensional Amide Proton Transfer-Weighted Imaging for Differentiating between Glioblastoma, IDH-Wildtype and Primary Central Nervous System Lymphoma |
| title_full | Three-Dimensional Amide Proton Transfer-Weighted Imaging for Differentiating between Glioblastoma, IDH-Wildtype and Primary Central Nervous System Lymphoma |
| title_fullStr | Three-Dimensional Amide Proton Transfer-Weighted Imaging for Differentiating between Glioblastoma, IDH-Wildtype and Primary Central Nervous System Lymphoma |
| title_full_unstemmed | Three-Dimensional Amide Proton Transfer-Weighted Imaging for Differentiating between Glioblastoma, IDH-Wildtype and Primary Central Nervous System Lymphoma |
| title_short | Three-Dimensional Amide Proton Transfer-Weighted Imaging for Differentiating between Glioblastoma, IDH-Wildtype and Primary Central Nervous System Lymphoma |
| title_sort | three dimensional amide proton transfer weighted imaging for differentiating between glioblastoma idh wildtype and primary central nervous system lymphoma |
| topic | APTw CEST glioblastoma MIB-1 index PCNSL |
| url | https://www.mdpi.com/2072-6694/15/3/952 |
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