Nano-Drug Delivery Systems Based on Different Targeting Mechanisms in the Targeted Therapy of Colorectal Cancer
Colorectal cancer (CRC) is a usual digestive tract malignancy and the third main cause of cancer death around the world, with a high occurrence rate and mortality rate. Conventional therapies for CRC have certain side effects and restrictions. However, the exciting thing is that with the rapid devel...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/9/2981 |
| _version_ | 1797503601299423232 |
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| author | Ke Wang Ruoyu Shen Tingting Meng Fuqiang Hu Hong Yuan |
| author_facet | Ke Wang Ruoyu Shen Tingting Meng Fuqiang Hu Hong Yuan |
| author_sort | Ke Wang |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is a usual digestive tract malignancy and the third main cause of cancer death around the world, with a high occurrence rate and mortality rate. Conventional therapies for CRC have certain side effects and restrictions. However, the exciting thing is that with the rapid development of nanotechnology, nanoparticles have gradually become more valuable drug delivery systems than traditional therapies because of their capacity to control drug release and target CRC. This also promotes the application of nano-drug targeted delivery systems in the therapy of CRC. Moreover, to make nanoparticles have a better colon targeting effect, many approaches have been used, including nanoparticles targeting CRC and in response to environmental signals. In this review, we focus on various targeting mechanisms of CRC-targeted nanoparticles and their latest research progress in the last three years, hoping to give researchers some inspiration on the design of CRC-targeted nanoparticles. |
| first_indexed | 2024-03-10T03:53:02Z |
| format | Article |
| id | doaj.art-c758f57c9f4845208905a76a0786d086 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:53:02Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c758f57c9f4845208905a76a0786d0862023-11-23T08:52:28ZengMDPI AGMolecules1420-30492022-05-01279298110.3390/molecules27092981Nano-Drug Delivery Systems Based on Different Targeting Mechanisms in the Targeted Therapy of Colorectal CancerKe Wang0Ruoyu Shen1Tingting Meng2Fuqiang Hu3Hong Yuan4College of Pharmaceutical Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, ChinaCollege of Pharmaceutical Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, ChinaCollege of Pharmaceutical Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, ChinaCollege of Pharmaceutical Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, ChinaCollege of Pharmaceutical Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, ChinaColorectal cancer (CRC) is a usual digestive tract malignancy and the third main cause of cancer death around the world, with a high occurrence rate and mortality rate. Conventional therapies for CRC have certain side effects and restrictions. However, the exciting thing is that with the rapid development of nanotechnology, nanoparticles have gradually become more valuable drug delivery systems than traditional therapies because of their capacity to control drug release and target CRC. This also promotes the application of nano-drug targeted delivery systems in the therapy of CRC. Moreover, to make nanoparticles have a better colon targeting effect, many approaches have been used, including nanoparticles targeting CRC and in response to environmental signals. In this review, we focus on various targeting mechanisms of CRC-targeted nanoparticles and their latest research progress in the last three years, hoping to give researchers some inspiration on the design of CRC-targeted nanoparticles.https://www.mdpi.com/1420-3049/27/9/2981targeted therapycolorectal cancernanoparticlesdrug delivery systems |
| spellingShingle | Ke Wang Ruoyu Shen Tingting Meng Fuqiang Hu Hong Yuan Nano-Drug Delivery Systems Based on Different Targeting Mechanisms in the Targeted Therapy of Colorectal Cancer Molecules targeted therapy colorectal cancer nanoparticles drug delivery systems |
| title | Nano-Drug Delivery Systems Based on Different Targeting Mechanisms in the Targeted Therapy of Colorectal Cancer |
| title_full | Nano-Drug Delivery Systems Based on Different Targeting Mechanisms in the Targeted Therapy of Colorectal Cancer |
| title_fullStr | Nano-Drug Delivery Systems Based on Different Targeting Mechanisms in the Targeted Therapy of Colorectal Cancer |
| title_full_unstemmed | Nano-Drug Delivery Systems Based on Different Targeting Mechanisms in the Targeted Therapy of Colorectal Cancer |
| title_short | Nano-Drug Delivery Systems Based on Different Targeting Mechanisms in the Targeted Therapy of Colorectal Cancer |
| title_sort | nano drug delivery systems based on different targeting mechanisms in the targeted therapy of colorectal cancer |
| topic | targeted therapy colorectal cancer nanoparticles drug delivery systems |
| url | https://www.mdpi.com/1420-3049/27/9/2981 |
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