Perinatal Hypoxia and Ischemia in Animal Models of Schizophrenia
Intrauterine or perinatal complications constitute a major risk for psychiatric diseases. Infants who suffered from hypoxia–ischemia (HI) are at twofold risk to develop schizophrenia in later life. Several animal models attempt to reproduce these complications to study the yet unknown steps between...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-03-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fpsyt.2018.00106/full |
| _version_ | 1818999209700884480 |
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| author | Dimitri Hefter Dimitri Hefter Hugo H. Marti Peter Gass Dragos Inta Dragos Inta |
| author_facet | Dimitri Hefter Dimitri Hefter Hugo H. Marti Peter Gass Dragos Inta Dragos Inta |
| author_sort | Dimitri Hefter |
| collection | DOAJ |
| description | Intrauterine or perinatal complications constitute a major risk for psychiatric diseases. Infants who suffered from hypoxia–ischemia (HI) are at twofold risk to develop schizophrenia in later life. Several animal models attempt to reproduce these complications to study the yet unknown steps between an insult in early life and outbreak of the disease decades later. However, it is very challenging to find the right type and severity of insult leading to a disease-like phenotype in the animal, but not causing necrosis and focal neurological deficits. By contrast, too mild, repetitive insults may even be protective via conditioning effects. Thus, it is not surprising that animal models of hypoxia lead to mixed results. To achieve clinically translatable findings, better protocols are urgently needed. Therefore, we compare widely used models of hypoxia and HI and propose future directions for the field. |
| first_indexed | 2024-12-20T22:13:47Z |
| format | Article |
| id | doaj.art-c75a13e5d22a470f83629669ae07583b |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-20T22:13:47Z |
| publishDate | 2018-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-c75a13e5d22a470f83629669ae07583b2022-12-21T19:25:06ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402018-03-01910.3389/fpsyt.2018.00106338432Perinatal Hypoxia and Ischemia in Animal Models of SchizophreniaDimitri Hefter0Dimitri Hefter1Hugo H. Marti2Peter Gass3Dragos Inta4Dragos Inta5RG Animal Models in Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Heidelberg, GermanyRG Neuro- and Sensory Physiology, Institute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, GermanyRG Neurovascular Research, Institute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, GermanyRG Animal Models in Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Heidelberg, GermanyRG Animal Models in Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Heidelberg, GermanyDepartment of Psychiatry, University of Basel, Basel, SwitzerlandIntrauterine or perinatal complications constitute a major risk for psychiatric diseases. Infants who suffered from hypoxia–ischemia (HI) are at twofold risk to develop schizophrenia in later life. Several animal models attempt to reproduce these complications to study the yet unknown steps between an insult in early life and outbreak of the disease decades later. However, it is very challenging to find the right type and severity of insult leading to a disease-like phenotype in the animal, but not causing necrosis and focal neurological deficits. By contrast, too mild, repetitive insults may even be protective via conditioning effects. Thus, it is not surprising that animal models of hypoxia lead to mixed results. To achieve clinically translatable findings, better protocols are urgently needed. Therefore, we compare widely used models of hypoxia and HI and propose future directions for the field.http://journal.frontiersin.org/article/10.3389/fpsyt.2018.00106/fullperinatalhypoxiaschizophreniaischemiaanimal modelsneurodevelopment |
| spellingShingle | Dimitri Hefter Dimitri Hefter Hugo H. Marti Peter Gass Dragos Inta Dragos Inta Perinatal Hypoxia and Ischemia in Animal Models of Schizophrenia Frontiers in Psychiatry perinatal hypoxia schizophrenia ischemia animal models neurodevelopment |
| title | Perinatal Hypoxia and Ischemia in Animal Models of Schizophrenia |
| title_full | Perinatal Hypoxia and Ischemia in Animal Models of Schizophrenia |
| title_fullStr | Perinatal Hypoxia and Ischemia in Animal Models of Schizophrenia |
| title_full_unstemmed | Perinatal Hypoxia and Ischemia in Animal Models of Schizophrenia |
| title_short | Perinatal Hypoxia and Ischemia in Animal Models of Schizophrenia |
| title_sort | perinatal hypoxia and ischemia in animal models of schizophrenia |
| topic | perinatal hypoxia schizophrenia ischemia animal models neurodevelopment |
| url | http://journal.frontiersin.org/article/10.3389/fpsyt.2018.00106/full |
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