Opportunities and options for surrogate assessment of insulin resistance
The high prevalence of type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular diseases (CVD) determines the need for early detection and correction of key markers of cardio-metabolic risk (CMR). This prophylactic direction is closely related to metabolic syndrome (MS) based on the concep...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2019-06-01
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| Series: | Ожирение и метаболизм |
| Subjects: | |
| Online Access: | https://www.omet-endojournals.ru/jour/article/view/10082 |
| _version_ | 1797204629890531328 |
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| author | Lyudmila A. Ruyatkina Dmitry S. Ruyatkin Irina S. Iskhakova |
| author_facet | Lyudmila A. Ruyatkina Dmitry S. Ruyatkin Irina S. Iskhakova |
| author_sort | Lyudmila A. Ruyatkina |
| collection | DOAJ |
| description | The high prevalence of type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular diseases (CVD) determines the need for early detection and correction of key markers of cardio-metabolic risk (CMR). This prophylactic direction is closely related to metabolic syndrome (MS) based on the concept of insulin resistance (IR). At the same time, IR is the first link in the pathogenesis of T2DM and is a recognized risk factor for atherothrombosis. Therefore, early diagnosis of IR is of practical importance both for the detection of early disorders of carbohydrate metabolism (DCM) and prognosis of T2DM, and cardiological risk. Alternative indicators have been proposed for evaluating IR with the inclusion of lipid and anthropometric parameters, the diagnostic and prognostic significance of which in terms of CMR (DCM and CVD) has been evaluated in randomized clinical trials in comparison with the HOMA-IR index and clamp. The TyG index (calculated on the basis of plasma glucose and triglycerides) is consistent with the phenomenon of glucolipotoxicity with subsequent metabolic disorders in target organs. Its derivatives are proposed: TyG-WC (TyG / waist circumference) and TYG-BMI (TyG / BMI). Apply LAP indices (lipid accumulation index) and VAI (visceral obesity index), as well as TG / HDL (TG / HDL). Their ethnic and gender differences were revealed, attempts were made to calculate the cut-off points for these indices. |
| first_indexed | 2024-03-08T09:13:38Z |
| format | Article |
| id | doaj.art-c75a21106e11490a9835d1e9888fe814 |
| institution | Directory Open Access Journal |
| issn | 2071-8713 2306-5524 |
| language | English |
| last_indexed | 2024-04-24T08:38:16Z |
| publishDate | 2019-06-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Ожирение и метаболизм |
| spelling | doaj.art-c75a21106e11490a9835d1e9888fe8142024-04-16T16:16:11ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242019-06-01161273310.14341/omet100828698Opportunities and options for surrogate assessment of insulin resistanceLyudmila A. Ruyatkina0Dmitry S. Ruyatkin1Irina S. Iskhakova2<p>Novosibirsk State Medical University; Novosibirsk Clinical Hospital №1</p><p>Novosibirsk State Medical University</p><p>Novosibirsk Clinical Hospital №1</p>The high prevalence of type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular diseases (CVD) determines the need for early detection and correction of key markers of cardio-metabolic risk (CMR). This prophylactic direction is closely related to metabolic syndrome (MS) based on the concept of insulin resistance (IR). At the same time, IR is the first link in the pathogenesis of T2DM and is a recognized risk factor for atherothrombosis. Therefore, early diagnosis of IR is of practical importance both for the detection of early disorders of carbohydrate metabolism (DCM) and prognosis of T2DM, and cardiological risk. Alternative indicators have been proposed for evaluating IR with the inclusion of lipid and anthropometric parameters, the diagnostic and prognostic significance of which in terms of CMR (DCM and CVD) has been evaluated in randomized clinical trials in comparison with the HOMA-IR index and clamp. The TyG index (calculated on the basis of plasma glucose and triglycerides) is consistent with the phenomenon of glucolipotoxicity with subsequent metabolic disorders in target organs. Its derivatives are proposed: TyG-WC (TyG / waist circumference) and TYG-BMI (TyG / BMI). Apply LAP indices (lipid accumulation index) and VAI (visceral obesity index), as well as TG / HDL (TG / HDL). Their ethnic and gender differences were revealed, attempts were made to calculate the cut-off points for these indices.https://www.omet-endojournals.ru/jour/article/view/10082metabolic syndromeinsulin resistancecardio-metabolic riskglucolipotoxicityinsulin resistance indexes |
| spellingShingle | Lyudmila A. Ruyatkina Dmitry S. Ruyatkin Irina S. Iskhakova Opportunities and options for surrogate assessment of insulin resistance Ожирение и метаболизм metabolic syndrome insulin resistance cardio-metabolic risk glucolipotoxicity insulin resistance indexes |
| title | Opportunities and options for surrogate assessment of insulin resistance |
| title_full | Opportunities and options for surrogate assessment of insulin resistance |
| title_fullStr | Opportunities and options for surrogate assessment of insulin resistance |
| title_full_unstemmed | Opportunities and options for surrogate assessment of insulin resistance |
| title_short | Opportunities and options for surrogate assessment of insulin resistance |
| title_sort | opportunities and options for surrogate assessment of insulin resistance |
| topic | metabolic syndrome insulin resistance cardio-metabolic risk glucolipotoxicity insulin resistance indexes |
| url | https://www.omet-endojournals.ru/jour/article/view/10082 |
| work_keys_str_mv | AT lyudmilaaruyatkina opportunitiesandoptionsforsurrogateassessmentofinsulinresistance AT dmitrysruyatkin opportunitiesandoptionsforsurrogateassessmentofinsulinresistance AT irinasiskhakova opportunitiesandoptionsforsurrogateassessmentofinsulinresistance |