Somatostatin slows Aβ plaque deposition in aged APP NL-F/NL-F mice by blocking Aβ aggregation

Somatostatin slows Aβ plaque deposition in aged APP NL-F/NL-F mice by blocking Aβ aggregation

Abstract The neuroendocrine peptide somatostatin (SST) has long been thought of as influencing the deposition of the amyloid β peptide (Aβ) in Alzheimer’s disease (AD). Missing have been in vivo data in a relevant Aβ amyloidosis model. Here we crossed App NL-F/NL-F mice with Sst-deficient mice to as...

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Bibliographic Details
Main Authors: Declan Williams, Bei Qi Yan, Hansen Wang, Logine Negm, Christopher Sackmann, Claire Verkuyl, Vanessa Rezai-Stevens, Shehab Eid, Nimit Vediya, Christine Sato, Joel C. Watts, Holger Wille, Gerold Schmitt-Ulms
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-29559-z

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