The Role of Exosomes and Exosomal Noncoding RNAs From Different Cell Sources in Spinal Cord Injury
Spinal cord injury (SCI) not only affects the quality of life of patients but also poses a heavy burden on their families. Therefore, it is essential to prevent the occurrence of SCI; for unpreventable SCI, it is critical to develop effective treatments. In recent years, various major breakthroughs...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2022.882306/full |
| _version_ | 1811304078984085504 |
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| author | Zhe-Lun Yang Jian Rao Fa-Bin Lin Ze-Yan Liang Xiong-Jie Xu Yi-Ke Lin Xin-Yao Chen Chun-Hua Wang Chun-Mei Chen |
| author_facet | Zhe-Lun Yang Jian Rao Fa-Bin Lin Ze-Yan Liang Xiong-Jie Xu Yi-Ke Lin Xin-Yao Chen Chun-Hua Wang Chun-Mei Chen |
| author_sort | Zhe-Lun Yang |
| collection | DOAJ |
| description | Spinal cord injury (SCI) not only affects the quality of life of patients but also poses a heavy burden on their families. Therefore, it is essential to prevent the occurrence of SCI; for unpreventable SCI, it is critical to develop effective treatments. In recent years, various major breakthroughs have been made in cell therapy to protect and regenerate the damaged spinal cord via various mechanisms such as immune regulation, paracrine signaling, extracellular matrix (ECM) modification, and lost cell replacement. Nevertheless, many recent studies have shown that the cell therapy has many disadvantages, such as tumorigenicity, low survival rate, and immune rejection. Because of these disadvantages, the clinical application of cell therapy is limited. In recent years, the role of exosomes in various diseases and their therapeutic potential have attracted much attention. The same is true for exosomal noncoding RNAs (ncRNAs), which do not encode proteins but affect transcriptional and translational processes by targeting specific mRNAs. This review focuses on the mechanism of action of exosomes obtained from different cell sources in the treatment of SCI and the regulatory role and therapeutic potential of exosomal ncRNAs. This review also discusses the future opportunities and challenges, proposing that exosomes and exosomal ncRNAs might be promising tools for the treatment of SCI. |
| first_indexed | 2024-04-13T07:59:37Z |
| format | Article |
| id | doaj.art-c75d83ac55ea4f83b403f8cbb527cf57 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-13T07:59:37Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-c75d83ac55ea4f83b403f8cbb527cf572022-12-22T02:55:19ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022022-04-011610.3389/fncel.2022.882306882306The Role of Exosomes and Exosomal Noncoding RNAs From Different Cell Sources in Spinal Cord InjuryZhe-Lun YangJian RaoFa-Bin LinZe-Yan LiangXiong-Jie XuYi-Ke LinXin-Yao ChenChun-Hua WangChun-Mei ChenSpinal cord injury (SCI) not only affects the quality of life of patients but also poses a heavy burden on their families. Therefore, it is essential to prevent the occurrence of SCI; for unpreventable SCI, it is critical to develop effective treatments. In recent years, various major breakthroughs have been made in cell therapy to protect and regenerate the damaged spinal cord via various mechanisms such as immune regulation, paracrine signaling, extracellular matrix (ECM) modification, and lost cell replacement. Nevertheless, many recent studies have shown that the cell therapy has many disadvantages, such as tumorigenicity, low survival rate, and immune rejection. Because of these disadvantages, the clinical application of cell therapy is limited. In recent years, the role of exosomes in various diseases and their therapeutic potential have attracted much attention. The same is true for exosomal noncoding RNAs (ncRNAs), which do not encode proteins but affect transcriptional and translational processes by targeting specific mRNAs. This review focuses on the mechanism of action of exosomes obtained from different cell sources in the treatment of SCI and the regulatory role and therapeutic potential of exosomal ncRNAs. This review also discusses the future opportunities and challenges, proposing that exosomes and exosomal ncRNAs might be promising tools for the treatment of SCI.https://www.frontiersin.org/articles/10.3389/fncel.2022.882306/fullspinal cord injuryexosomemesenchymal stem cellneural stem cellnoncoding RNAs |
| spellingShingle | Zhe-Lun Yang Jian Rao Fa-Bin Lin Ze-Yan Liang Xiong-Jie Xu Yi-Ke Lin Xin-Yao Chen Chun-Hua Wang Chun-Mei Chen The Role of Exosomes and Exosomal Noncoding RNAs From Different Cell Sources in Spinal Cord Injury Frontiers in Cellular Neuroscience spinal cord injury exosome mesenchymal stem cell neural stem cell noncoding RNAs |
| title | The Role of Exosomes and Exosomal Noncoding RNAs From Different Cell Sources in Spinal Cord Injury |
| title_full | The Role of Exosomes and Exosomal Noncoding RNAs From Different Cell Sources in Spinal Cord Injury |
| title_fullStr | The Role of Exosomes and Exosomal Noncoding RNAs From Different Cell Sources in Spinal Cord Injury |
| title_full_unstemmed | The Role of Exosomes and Exosomal Noncoding RNAs From Different Cell Sources in Spinal Cord Injury |
| title_short | The Role of Exosomes and Exosomal Noncoding RNAs From Different Cell Sources in Spinal Cord Injury |
| title_sort | role of exosomes and exosomal noncoding rnas from different cell sources in spinal cord injury |
| topic | spinal cord injury exosome mesenchymal stem cell neural stem cell noncoding RNAs |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2022.882306/full |
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