Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
The tumour microenvironment in mTORC1 hyperactive cancers remains poorly characterised. Here, integrative analysis in tuberous sclerosis complex tumours with mTORC1 hyperactivity suggests distinct cell states associated with rapamycin resistance and immune modulation.
Main Authors: | , , |
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Format: | Article |
Language: | English |
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Nature Portfolio
2022-08-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-32673-7 |
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author | Yan Tang David J. Kwiatkowski Elizabeth P. Henske |
author_facet | Yan Tang David J. Kwiatkowski Elizabeth P. Henske |
author_sort | Yan Tang |
collection | DOAJ |
description | The tumour microenvironment in mTORC1 hyperactive cancers remains poorly characterised. Here, integrative analysis in tuberous sclerosis complex tumours with mTORC1 hyperactivity suggests distinct cell states associated with rapamycin resistance and immune modulation. |
first_indexed | 2024-12-10T19:21:15Z |
format | Article |
id | doaj.art-c7618ced00e3494296ba20b027e046e6 |
institution | Directory Open Access Journal |
issn | 2041-1723 |
language | English |
last_indexed | 2024-12-10T19:21:15Z |
publishDate | 2022-08-01 |
publisher | Nature Portfolio |
record_format | Article |
series | Nature Communications |
spelling | doaj.art-c7618ced00e3494296ba20b027e046e62022-12-22T01:36:29ZengNature PortfolioNature Communications2041-17232022-08-0113112210.1038/s41467-022-32673-7Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironmentYan Tang0David J. Kwiatkowski1Elizabeth P. Henske2Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolDivision of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolDivision of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolThe tumour microenvironment in mTORC1 hyperactive cancers remains poorly characterised. Here, integrative analysis in tuberous sclerosis complex tumours with mTORC1 hyperactivity suggests distinct cell states associated with rapamycin resistance and immune modulation.https://doi.org/10.1038/s41467-022-32673-7 |
spellingShingle | Yan Tang David J. Kwiatkowski Elizabeth P. Henske Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment Nature Communications |
title | Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment |
title_full | Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment |
title_fullStr | Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment |
title_full_unstemmed | Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment |
title_short | Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment |
title_sort | midkine expression by stem like tumor cells drives persistence to mtor inhibition and an immune suppressive microenvironment |
url | https://doi.org/10.1038/s41467-022-32673-7 |
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