Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment

The tumour microenvironment in mTORC1 hyperactive cancers remains poorly characterised. Here, integrative analysis in tuberous sclerosis complex tumours with mTORC1 hyperactivity suggests distinct cell states associated with rapamycin resistance and immune modulation.

Bibliographic Details
Main Authors: Yan Tang, David J. Kwiatkowski, Elizabeth P. Henske
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32673-7
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author Yan Tang
David J. Kwiatkowski
Elizabeth P. Henske
author_facet Yan Tang
David J. Kwiatkowski
Elizabeth P. Henske
author_sort Yan Tang
collection DOAJ
description The tumour microenvironment in mTORC1 hyperactive cancers remains poorly characterised. Here, integrative analysis in tuberous sclerosis complex tumours with mTORC1 hyperactivity suggests distinct cell states associated with rapamycin resistance and immune modulation.
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spelling doaj.art-c7618ced00e3494296ba20b027e046e62022-12-22T01:36:29ZengNature PortfolioNature Communications2041-17232022-08-0113112210.1038/s41467-022-32673-7Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironmentYan Tang0David J. Kwiatkowski1Elizabeth P. Henske2Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolDivision of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolDivision of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolThe tumour microenvironment in mTORC1 hyperactive cancers remains poorly characterised. Here, integrative analysis in tuberous sclerosis complex tumours with mTORC1 hyperactivity suggests distinct cell states associated with rapamycin resistance and immune modulation.https://doi.org/10.1038/s41467-022-32673-7
spellingShingle Yan Tang
David J. Kwiatkowski
Elizabeth P. Henske
Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
Nature Communications
title Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
title_full Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
title_fullStr Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
title_full_unstemmed Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
title_short Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
title_sort midkine expression by stem like tumor cells drives persistence to mtor inhibition and an immune suppressive microenvironment
url https://doi.org/10.1038/s41467-022-32673-7
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AT elizabethphenske midkineexpressionbystemliketumorcellsdrivespersistencetomtorinhibitionandanimmunesuppressivemicroenvironment