The serial changes of Neutrophile-Lymphocyte Ratio and correlation to weight loss after Laparoscopic Sleeve Gastrectomy
PurposeThis study aims to identify the pre- and postoperative changes in the neutrophil-lymphocyte ratio (NLR) and its correlations to clinical characteristics in obese patients who underwent laparoscopic sleeve gastrectomy (LSG).MethodRetrospectively, we included patients who has undergone LSG in o...
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| Format: | Article |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.939857/full |
| _version_ | 1798002388467974144 |
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| author | Po-Jui Chi Po-Jui Chi Kun-Ta Wu Kun-Ta Wu Po-Jen Chen Chung-Yen Chen Chung-Yen Chen Chung-Yen Chen Yu-Chieh Su Yu-Chieh Su Chung-Yi Yang Chung-Yi Yang Jian-Han Chen Jian-Han Chen Jian-Han Chen |
| author_facet | Po-Jui Chi Po-Jui Chi Kun-Ta Wu Kun-Ta Wu Po-Jen Chen Chung-Yen Chen Chung-Yen Chen Chung-Yen Chen Yu-Chieh Su Yu-Chieh Su Chung-Yi Yang Chung-Yi Yang Jian-Han Chen Jian-Han Chen Jian-Han Chen |
| author_sort | Po-Jui Chi |
| collection | DOAJ |
| description | PurposeThis study aims to identify the pre- and postoperative changes in the neutrophil-lymphocyte ratio (NLR) and its correlations to clinical characteristics in obese patients who underwent laparoscopic sleeve gastrectomy (LSG).MethodRetrospectively, we included patients who has undergone LSG in our institution between January 2019 and April 2021. A total of 100 patients whose body mass index over 32.5 and received primary laparoscopic sleeve gastrectomy without infectious condition were included.ResultsThere was a significant decline in NLR (T0 vs. POM3 2.21 vs. 1.78, p = 0.005), neutrophil (T0 vs. POM3 5369 vs. 4050, p < 0.001) and lymphocyte count (T0 vs. POM3 2440: 2100, p < 0.001, respectively) at postoperative 3 months (POM3) compared to preoperative (T0) levels, but similar between POM3 and POM6. The declined counts (Neutrophile vs. Lymphocyte 1445.5/µl vs. 323.5/µl, p < 0.001) and percentage (Neutrophile vs. Lymphocyte 25.11% vs. 13.07%, p < 0.001) of neutrophile are higher than lymphocyte from T0 to POM3, but similar in POM3 and POM6. Preoperative NLR has a significant correlation with the preoperative body weight, preoperative insulin level, and excessive body weight loss (EBWL) at POM3. Preoperative NLR <2.36 had a sensitivity of 67.6% and a specificity of 62.5% in predicting successful weight loss (EBWL > 37.7%) at POM3 (AUC = 0.635, p = 0.032).ConclusionThere was a significant decline in NLR, neutrophil, and lymphocyte count from T0 to POM3, but similar between POM3 and POM6. The declined counts and percentage of neutrophile are higher than lymphocyte. Preoperative NLR shows the potential to be used as a prognostic biomarker for predicting successful weight loss at POM3 after LSG. Further studies could be designed to evaluate the value of prediction in successful outcome after LSG and figure out the relationship between the changes of neutrophil function and oncogenesis. |
| first_indexed | 2024-04-11T11:51:22Z |
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| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-11T11:51:22Z |
| publishDate | 2022-09-01 |
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| series | Frontiers in Surgery |
| spelling | doaj.art-c76227b9874543afad93118d3f5557322022-12-22T04:25:23ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-09-01910.3389/fsurg.2022.939857939857The serial changes of Neutrophile-Lymphocyte Ratio and correlation to weight loss after Laparoscopic Sleeve GastrectomyPo-Jui Chi0Po-Jui Chi1Kun-Ta Wu2Kun-Ta Wu3Po-Jen Chen4Chung-Yen Chen5Chung-Yen Chen6Chung-Yen Chen7Yu-Chieh Su8Yu-Chieh Su9Chung-Yi Yang10Chung-Yi Yang11Jian-Han Chen12Jian-Han Chen13Jian-Han Chen14Division of Nephrology, Department of Medicine, E-DA Hospital, TaiwanSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung, TaiwanDivision of General Surgery, Department of Surgery, E-Da Hospital, TaiwanDivision of General Surgery, E-Da Cancer Hospital, Kaohsiung, TaiwanDepartment of Medical Research, E-Da Hospital, TaiwanSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung, TaiwanDivision of General Surgery, Department of Surgery, E-Da Hospital, TaiwanBariatric and Metabolism International Surgery Center, E-Da Hospital, Kaohsiung, TaiwanSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung, TaiwanDivision of Hematology-Oncology, E-Da Hospital, Kaohsiung, TaiwanSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung, TaiwanDepartment of Medical Imaging, E-Da Hospital, Kaohsiung, TaiwanSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung, TaiwanDivision of General Surgery, Department of Surgery, E-Da Hospital, TaiwanBariatric and Metabolism International Surgery Center, E-Da Hospital, Kaohsiung, TaiwanPurposeThis study aims to identify the pre- and postoperative changes in the neutrophil-lymphocyte ratio (NLR) and its correlations to clinical characteristics in obese patients who underwent laparoscopic sleeve gastrectomy (LSG).MethodRetrospectively, we included patients who has undergone LSG in our institution between January 2019 and April 2021. A total of 100 patients whose body mass index over 32.5 and received primary laparoscopic sleeve gastrectomy without infectious condition were included.ResultsThere was a significant decline in NLR (T0 vs. POM3 2.21 vs. 1.78, p = 0.005), neutrophil (T0 vs. POM3 5369 vs. 4050, p < 0.001) and lymphocyte count (T0 vs. POM3 2440: 2100, p < 0.001, respectively) at postoperative 3 months (POM3) compared to preoperative (T0) levels, but similar between POM3 and POM6. The declined counts (Neutrophile vs. Lymphocyte 1445.5/µl vs. 323.5/µl, p < 0.001) and percentage (Neutrophile vs. Lymphocyte 25.11% vs. 13.07%, p < 0.001) of neutrophile are higher than lymphocyte from T0 to POM3, but similar in POM3 and POM6. Preoperative NLR has a significant correlation with the preoperative body weight, preoperative insulin level, and excessive body weight loss (EBWL) at POM3. Preoperative NLR <2.36 had a sensitivity of 67.6% and a specificity of 62.5% in predicting successful weight loss (EBWL > 37.7%) at POM3 (AUC = 0.635, p = 0.032).ConclusionThere was a significant decline in NLR, neutrophil, and lymphocyte count from T0 to POM3, but similar between POM3 and POM6. The declined counts and percentage of neutrophile are higher than lymphocyte. Preoperative NLR shows the potential to be used as a prognostic biomarker for predicting successful weight loss at POM3 after LSG. Further studies could be designed to evaluate the value of prediction in successful outcome after LSG and figure out the relationship between the changes of neutrophil function and oncogenesis.https://www.frontiersin.org/articles/10.3389/fsurg.2022.939857/fullmaximize effectneutrophil-lymphocyte ratio (NLR)chronic inflammationlaparoscopic sleeve gastrectomyimmunologyprediction |
| spellingShingle | Po-Jui Chi Po-Jui Chi Kun-Ta Wu Kun-Ta Wu Po-Jen Chen Chung-Yen Chen Chung-Yen Chen Chung-Yen Chen Yu-Chieh Su Yu-Chieh Su Chung-Yi Yang Chung-Yi Yang Jian-Han Chen Jian-Han Chen Jian-Han Chen The serial changes of Neutrophile-Lymphocyte Ratio and correlation to weight loss after Laparoscopic Sleeve Gastrectomy Frontiers in Surgery maximize effect neutrophil-lymphocyte ratio (NLR) chronic inflammation laparoscopic sleeve gastrectomy immunology prediction |
| title | The serial changes of Neutrophile-Lymphocyte Ratio and correlation to weight loss after Laparoscopic Sleeve Gastrectomy |
| title_full | The serial changes of Neutrophile-Lymphocyte Ratio and correlation to weight loss after Laparoscopic Sleeve Gastrectomy |
| title_fullStr | The serial changes of Neutrophile-Lymphocyte Ratio and correlation to weight loss after Laparoscopic Sleeve Gastrectomy |
| title_full_unstemmed | The serial changes of Neutrophile-Lymphocyte Ratio and correlation to weight loss after Laparoscopic Sleeve Gastrectomy |
| title_short | The serial changes of Neutrophile-Lymphocyte Ratio and correlation to weight loss after Laparoscopic Sleeve Gastrectomy |
| title_sort | serial changes of neutrophile lymphocyte ratio and correlation to weight loss after laparoscopic sleeve gastrectomy |
| topic | maximize effect neutrophil-lymphocyte ratio (NLR) chronic inflammation laparoscopic sleeve gastrectomy immunology prediction |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.939857/full |
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