VACCINE-CHALLENGED IMMUNE RESISTANCE TOWARD VIRUS A/CALIFORNIA/7/2009(H1N1)v IN IMMUNIZED PREGNANT WOMEN
Abstract. We studied immune resistance efficiency of vaccination against influenza A/California/7/2009(H1N1)v in women at second trimester of physiological pregnancy in a blind, placebocontrolled study. The first group included thirty pregnant women who were injected by univalent subunit “MonoGrippo...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
|
| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/612 |
| _version_ | 1797198046925160448 |
|---|---|
| author | A. Cherdantsev M. Kostinov А. Kuselman Y. Dagil A. A. Savis’ko |
| author_facet | A. Cherdantsev M. Kostinov А. Kuselman Y. Dagil A. A. Savis’ko |
| author_sort | A. Cherdantsev |
| collection | DOAJ |
| description | Abstract. We studied immune resistance efficiency of vaccination against influenza A/California/7/2009(H1N1)v in women at second trimester of physiological pregnancy in a blind, placebocontrolled study. The first group included thirty pregnant women who were injected by univalent subunit “MonoGrippol plus” vaccine. The second group consisted of thirty-seven pregnant women immunized by trivalent “Grippol plus” vaccine. Thirty-one pregnant women (III group) received placebo treatment. Non-pregnant women (IV group) were injected with “MonoGrippol plus”. We did not find any differences in clinical features of vacccine-challenged time period in pregnant women from groups I-III. Notably, sufficient numbers of women were found to be seroprotected 1 month post-vaccination (I group, 80.0% ; II group, 75.7% ; IVgroup, 80.6% ) with high levels seroconversion (I group, 46.6%; II group, 51.4%; IV group, 53.3%). Within 9-10 months after vaccination, a decreased seroprotection was revealed in II group of pregnant women. More stable specific immunity levels were detected for the groups immunized with univalent vaccine.Hence, the local subunit adjuvant “MonoGrippol plus” and “Grippol plus” vaccines were shown to exibit a high immune resistance efficiency profile and clinical safety, when used in pregnant women, thus presuming an extended application field for these biological drugs in public health service. State of pregnancy seems not to be a limiting condition for induction of specific immune resistance. |
| first_indexed | 2024-03-08T05:51:04Z |
| format | Article |
| id | doaj.art-c76253e92ee940d1ae843281e0d125cd |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:53:38Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-c76253e92ee940d1ae843281e0d125cd2024-04-22T13:07:38ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0114652753210.15789/1563-0625-2012-6-527-532609VACCINE-CHALLENGED IMMUNE RESISTANCE TOWARD VIRUS A/CALIFORNIA/7/2009(H1N1)v IN IMMUNIZED PREGNANT WOMENA. Cherdantsev0M. Kostinov1А. Kuselman2Y. Dagil3A. A. Savis’ko4ФГБОУ ВПО Ульяновский государственный университет, г. УльяновскНИИВС им. И.И. Мечникова, РАМН, МоскваФГБОУ ВПО Ульяновский государственный университет, г. УльяновскНИИВС им. И.И. Мечникова, РАМН, МоскваФГБОУ ВПО Ростовский государственный медицинский университет, г. Ростов-на-ДонуAbstract. We studied immune resistance efficiency of vaccination against influenza A/California/7/2009(H1N1)v in women at second trimester of physiological pregnancy in a blind, placebocontrolled study. The first group included thirty pregnant women who were injected by univalent subunit “MonoGrippol plus” vaccine. The second group consisted of thirty-seven pregnant women immunized by trivalent “Grippol plus” vaccine. Thirty-one pregnant women (III group) received placebo treatment. Non-pregnant women (IV group) were injected with “MonoGrippol plus”. We did not find any differences in clinical features of vacccine-challenged time period in pregnant women from groups I-III. Notably, sufficient numbers of women were found to be seroprotected 1 month post-vaccination (I group, 80.0% ; II group, 75.7% ; IVgroup, 80.6% ) with high levels seroconversion (I group, 46.6%; II group, 51.4%; IV group, 53.3%). Within 9-10 months after vaccination, a decreased seroprotection was revealed in II group of pregnant women. More stable specific immunity levels were detected for the groups immunized with univalent vaccine.Hence, the local subunit adjuvant “MonoGrippol plus” and “Grippol plus” vaccines were shown to exibit a high immune resistance efficiency profile and clinical safety, when used in pregnant women, thus presuming an extended application field for these biological drugs in public health service. State of pregnancy seems not to be a limiting condition for induction of specific immune resistance.https://www.mimmun.ru/mimmun/article/view/612influenzapregnancyvaccination |
| spellingShingle | A. Cherdantsev M. Kostinov А. Kuselman Y. Dagil A. A. Savis’ko VACCINE-CHALLENGED IMMUNE RESISTANCE TOWARD VIRUS A/CALIFORNIA/7/2009(H1N1)v IN IMMUNIZED PREGNANT WOMEN Медицинская иммунология influenza pregnancy vaccination |
| title | VACCINE-CHALLENGED IMMUNE RESISTANCE TOWARD VIRUS A/CALIFORNIA/7/2009(H1N1)v IN IMMUNIZED PREGNANT WOMEN |
| title_full | VACCINE-CHALLENGED IMMUNE RESISTANCE TOWARD VIRUS A/CALIFORNIA/7/2009(H1N1)v IN IMMUNIZED PREGNANT WOMEN |
| title_fullStr | VACCINE-CHALLENGED IMMUNE RESISTANCE TOWARD VIRUS A/CALIFORNIA/7/2009(H1N1)v IN IMMUNIZED PREGNANT WOMEN |
| title_full_unstemmed | VACCINE-CHALLENGED IMMUNE RESISTANCE TOWARD VIRUS A/CALIFORNIA/7/2009(H1N1)v IN IMMUNIZED PREGNANT WOMEN |
| title_short | VACCINE-CHALLENGED IMMUNE RESISTANCE TOWARD VIRUS A/CALIFORNIA/7/2009(H1N1)v IN IMMUNIZED PREGNANT WOMEN |
| title_sort | vaccine challenged immune resistance toward virus a california 7 2009 h1n1 v in immunized pregnant women |
| topic | influenza pregnancy vaccination |
| url | https://www.mimmun.ru/mimmun/article/view/612 |
| work_keys_str_mv | AT acherdantsev vaccinechallengedimmuneresistancetowardvirusacalifornia72009h1n1vinimmunizedpregnantwomen AT mkostinov vaccinechallengedimmuneresistancetowardvirusacalifornia72009h1n1vinimmunizedpregnantwomen AT akuselman vaccinechallengedimmuneresistancetowardvirusacalifornia72009h1n1vinimmunizedpregnantwomen AT ydagil vaccinechallengedimmuneresistancetowardvirusacalifornia72009h1n1vinimmunizedpregnantwomen AT aasavisko vaccinechallengedimmuneresistancetowardvirusacalifornia72009h1n1vinimmunizedpregnantwomen |