Safety and efficacy of l‐arginine produced by fermentation with Corynebacterium glutamicum KCCM 80182 for all animal species
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐arginine produced by fermentation with a genetically modified strain of Corynebacterium glutamicum KCCM 80182 when...
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| Format: | Article |
| Language: | English |
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Wiley
2019-05-01
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| Series: | EFSA Journal |
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| Online Access: | https://doi.org/10.2903/j.efsa.2019.5696 |
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| author | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Birgit Dusemund Maryline Kouba Mojca Kos Durjava Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Lieve Herman Boet Glandorf Maria Saarela Montserrat Anguita Jaume Galobart Orsolya Holczknecht Jordi Tarrés‐Call Elisa Pettenati Fabiola Pizzo Paola Manini |
| author_facet | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Birgit Dusemund Maryline Kouba Mojca Kos Durjava Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Lieve Herman Boet Glandorf Maria Saarela Montserrat Anguita Jaume Galobart Orsolya Holczknecht Jordi Tarrés‐Call Elisa Pettenati Fabiola Pizzo Paola Manini |
| author_sort | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) |
| collection | DOAJ |
| description | Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐arginine produced by fermentation with a genetically modified strain of Corynebacterium glutamicum KCCM 80182 when used as a nutritional additive in feed and water for drinking for all animal species categories. Viable cells of the production strain and its recombinant DNA were not detected in the additive. The product l‐arginine, manufactured by fermentation with C. glutamicum, KCCM 80182, does not give rise to any safety concern with regard to the production strain. l‐Arginine produced using C. glutamicum KCCM 80182 is considered safe for the target species. The FEEDAP Panel has concerns regarding the safety of the simultaneous oral administration of l‐arginine via water for drinking and feed. l‐Arginine produced using C. glutamicum KCCM 80182 is safe for the consumer and for the environment. The additive is not hazardous by inhalation, is not a skin sensitiser, but is corrosive to skin and eyes. The product under assessment is considered an efficacious source of the amino acid l‐arginine for all animal species. For l‐arginine to be as efficacious in ruminants as in non‐ruminant species, it requires protection against microbial degradation in the rumen. |
| first_indexed | 2024-12-22T10:17:28Z |
| format | Article |
| id | doaj.art-c763132757bb420db082f56aee759860 |
| institution | Directory Open Access Journal |
| issn | 1831-4732 |
| language | English |
| last_indexed | 2024-12-22T10:17:28Z |
| publishDate | 2019-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj.art-c763132757bb420db082f56aee7598602022-12-21T18:29:43ZengWileyEFSA Journal1831-47322019-05-01175n/an/a10.2903/j.efsa.2019.5696Safety and efficacy of l‐arginine produced by fermentation with Corynebacterium glutamicum KCCM 80182 for all animal speciesEFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Vasileios BampidisGiovanna AzimontiMaria de Lourdes BastosHenrik ChristensenBirgit DusemundMaryline KoubaMojca Kos DurjavaMarta López‐AlonsoSecundino López PuenteFrancesca MarconBaltasar MayoAlena PechováMariana PetkovaFernando RamosYolanda SanzRoberto Edoardo VillaRuud WoutersenLieve HermanBoet GlandorfMaria SaarelaMontserrat AnguitaJaume GalobartOrsolya HolczknechtJordi Tarrés‐CallElisa PettenatiFabiola PizzoPaola ManiniAbstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐arginine produced by fermentation with a genetically modified strain of Corynebacterium glutamicum KCCM 80182 when used as a nutritional additive in feed and water for drinking for all animal species categories. Viable cells of the production strain and its recombinant DNA were not detected in the additive. The product l‐arginine, manufactured by fermentation with C. glutamicum, KCCM 80182, does not give rise to any safety concern with regard to the production strain. l‐Arginine produced using C. glutamicum KCCM 80182 is considered safe for the target species. The FEEDAP Panel has concerns regarding the safety of the simultaneous oral administration of l‐arginine via water for drinking and feed. l‐Arginine produced using C. glutamicum KCCM 80182 is safe for the consumer and for the environment. The additive is not hazardous by inhalation, is not a skin sensitiser, but is corrosive to skin and eyes. The product under assessment is considered an efficacious source of the amino acid l‐arginine for all animal species. For l‐arginine to be as efficacious in ruminants as in non‐ruminant species, it requires protection against microbial degradation in the rumen.https://doi.org/10.2903/j.efsa.2019.5696nutritional additiveamino acidsl‐argininegenetically modified production strainC. glutamicum KCCM 80182Safety |
| spellingShingle | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Birgit Dusemund Maryline Kouba Mojca Kos Durjava Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Lieve Herman Boet Glandorf Maria Saarela Montserrat Anguita Jaume Galobart Orsolya Holczknecht Jordi Tarrés‐Call Elisa Pettenati Fabiola Pizzo Paola Manini Safety and efficacy of l‐arginine produced by fermentation with Corynebacterium glutamicum KCCM 80182 for all animal species EFSA Journal nutritional additive amino acids l‐arginine genetically modified production strain C. glutamicum KCCM 80182 Safety |
| title | Safety and efficacy of l‐arginine produced by fermentation with Corynebacterium glutamicum KCCM 80182 for all animal species |
| title_full | Safety and efficacy of l‐arginine produced by fermentation with Corynebacterium glutamicum KCCM 80182 for all animal species |
| title_fullStr | Safety and efficacy of l‐arginine produced by fermentation with Corynebacterium glutamicum KCCM 80182 for all animal species |
| title_full_unstemmed | Safety and efficacy of l‐arginine produced by fermentation with Corynebacterium glutamicum KCCM 80182 for all animal species |
| title_short | Safety and efficacy of l‐arginine produced by fermentation with Corynebacterium glutamicum KCCM 80182 for all animal species |
| title_sort | safety and efficacy of l arginine produced by fermentation with corynebacterium glutamicum kccm 80182 for all animal species |
| topic | nutritional additive amino acids l‐arginine genetically modified production strain C. glutamicum KCCM 80182 Safety |
| url | https://doi.org/10.2903/j.efsa.2019.5696 |
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