Expanding the Genetic Code of Lactococcus lactis and Escherichia coli to Incorporate Non-canonical Amino Acids for Production of Modified Lantibiotics

Expanding the Genetic Code of Lactococcus lactis and Escherichia coli to Incorporate Non-canonical Amino Acids for Production of Modified Lantibiotics

The incorporation of non-canonical amino acids (ncAAs) into ribosomally synthesized and post-translationally modified peptides, e.g., nisin from the Gram-positive bacterium Lactococcus lactis, bears great potential to expand the chemical space of various antimicrobials. The ncAA Nε-Boc-L-lysine (Boc...

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Bibliographic Details
Main Authors: Maike Bartholomae, Tobias Baumann, Jessica H. Nickling, David Peterhoff, Ralf Wagner, Nediljko Budisa, Oscar P. Kuipers
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Microbiology
Subjects:
stop codon suppression
pyrrolysyl-tRNA synthetase
nisin
orthogonal translation system
antimicrobial peptides
bacteriocin
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00657/full

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