Influenza infection is not associated with phenotypical frailty in older patients, a prospective cohort study
Abstract Background and Aims Influenza is a challenging infectious illness for older adults. It is not completely clear whether influenza is associated with frailty or functional decline. We sought to determine the association between incident influenza infection and frailty and prefrailty in commun...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-09-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.750 |
| _version_ | 1797772343249993728 |
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| author | Paul Takahashi Chung‐Il Wi Euijung Ryu Katherine King Joel Hickman Robert Pignolo Young Juhn |
| author_facet | Paul Takahashi Chung‐Il Wi Euijung Ryu Katherine King Joel Hickman Robert Pignolo Young Juhn |
| author_sort | Paul Takahashi |
| collection | DOAJ |
| description | Abstract Background and Aims Influenza is a challenging infectious illness for older adults. It is not completely clear whether influenza is associated with frailty or functional decline. We sought to determine the association between incident influenza infection and frailty and prefrailty in community patients over 50 years of age. We also investigated the association between influenza vaccination and frailty and prefrailty as a secondary aim. Methods This was a prospective community cohort study from October 2019 to November 2020 in participants over 50 years. The primary outcome was the development of frailty as defined by three of five frailty criteria (slow gait speed, low grip strength, 5% weight loss, low energy, and low physical functioning). The primary predictor was a positive polymerase chain reaction (PCR) for influenza infection. Influenza vaccination was based on electronic health record reviewing 1 year before enrollment. We reported the relationship between influenza and frailty by calculating odds ratios (OR) with 95% confidence intervals (CI) after adjustment for age, sex, socioeconomic status, Charlson Comorbidity Index (CCI), influenza vaccine, and previous self‐rated frailty from multinomial logistic regression model comparing frail and prefrail to nonfrail subjects. Results In 1135 participants, the median age was 67 years (interquartile range 60−74), with 41% men. Eighty‐one participants had PCR‐confirmed influenza (7.1%). Frailty was not associated with influenza, with an OR of 0.50 (95% CI 0.17−1.43) for frail participants compared to nonfrail participants. Influenza vaccination is associated with frailty, with an OR of 1.69 (95% CI 1.09−2.63) for frail compared to nonfrail. Frailty was associated with a higher CCI with an OR of 1.52 (95% CI 1.31−1.76). Conclusion We did not find a relationship between influenza infection and frailty. We found higher vaccination rates in participants with frailty compared to nonfrail participants While influenza was not associated with frailty, future work may involve longer follow‐up. |
| first_indexed | 2024-03-12T21:50:34Z |
| format | Article |
| id | doaj.art-c7641d8a45674f2abb7a12e0c843ba09 |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-12T21:50:34Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-c7641d8a45674f2abb7a12e0c843ba092023-07-26T04:11:54ZengWileyHealth Science Reports2398-88352022-09-0155n/an/a10.1002/hsr2.750Influenza infection is not associated with phenotypical frailty in older patients, a prospective cohort studyPaul Takahashi0Chung‐Il Wi1Euijung Ryu2Katherine King3Joel Hickman4Robert Pignolo5Young Juhn6Mayo Clinic Rochester Rochester Minnesota USAMayo Clinic Rochester, Health Science Research Rochester Minnesota USAMayo Clinic Rochester Rochester Minnesota USAMayo Clinic Rochester Rochester Minnesota USAMayo Clinic Rochester Rochester Minnesota USAMayo Clinic College of Medicine and Science Rochester Minnesota USAMayo Clinic Rochester Rochester Minnesota USAAbstract Background and Aims Influenza is a challenging infectious illness for older adults. It is not completely clear whether influenza is associated with frailty or functional decline. We sought to determine the association between incident influenza infection and frailty and prefrailty in community patients over 50 years of age. We also investigated the association between influenza vaccination and frailty and prefrailty as a secondary aim. Methods This was a prospective community cohort study from October 2019 to November 2020 in participants over 50 years. The primary outcome was the development of frailty as defined by three of five frailty criteria (slow gait speed, low grip strength, 5% weight loss, low energy, and low physical functioning). The primary predictor was a positive polymerase chain reaction (PCR) for influenza infection. Influenza vaccination was based on electronic health record reviewing 1 year before enrollment. We reported the relationship between influenza and frailty by calculating odds ratios (OR) with 95% confidence intervals (CI) after adjustment for age, sex, socioeconomic status, Charlson Comorbidity Index (CCI), influenza vaccine, and previous self‐rated frailty from multinomial logistic regression model comparing frail and prefrail to nonfrail subjects. Results In 1135 participants, the median age was 67 years (interquartile range 60−74), with 41% men. Eighty‐one participants had PCR‐confirmed influenza (7.1%). Frailty was not associated with influenza, with an OR of 0.50 (95% CI 0.17−1.43) for frail participants compared to nonfrail participants. Influenza vaccination is associated with frailty, with an OR of 1.69 (95% CI 1.09−2.63) for frail compared to nonfrail. Frailty was associated with a higher CCI with an OR of 1.52 (95% CI 1.31−1.76). Conclusion We did not find a relationship between influenza infection and frailty. We found higher vaccination rates in participants with frailty compared to nonfrail participants While influenza was not associated with frailty, future work may involve longer follow‐up.https://doi.org/10.1002/hsr2.750frailtyInfluenzaolder adultsvaccination |
| spellingShingle | Paul Takahashi Chung‐Il Wi Euijung Ryu Katherine King Joel Hickman Robert Pignolo Young Juhn Influenza infection is not associated with phenotypical frailty in older patients, a prospective cohort study Health Science Reports frailty Influenza older adults vaccination |
| title | Influenza infection is not associated with phenotypical frailty in older patients, a prospective cohort study |
| title_full | Influenza infection is not associated with phenotypical frailty in older patients, a prospective cohort study |
| title_fullStr | Influenza infection is not associated with phenotypical frailty in older patients, a prospective cohort study |
| title_full_unstemmed | Influenza infection is not associated with phenotypical frailty in older patients, a prospective cohort study |
| title_short | Influenza infection is not associated with phenotypical frailty in older patients, a prospective cohort study |
| title_sort | influenza infection is not associated with phenotypical frailty in older patients a prospective cohort study |
| topic | frailty Influenza older adults vaccination |
| url | https://doi.org/10.1002/hsr2.750 |
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