Role of the spleen in patients with liver cancer and cirrhosis
The spleen is the largest lymphoid organ that can affect the immunological microenvironment in the liver via the portal system. Patients with liver cancer, often develop hypersplenism and splenomegaly from underlying cirrhosis and portal hypertension. The malfunction of the spleen not only induces h...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Surgery Concepts & Practice
2023-07-01
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| Series: | Waike lilun yu shijian |
| Subjects: | |
| Online Access: | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1698117200426-1884798663.pdf |
| _version_ | 1797648530569953280 |
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| author | CHANG Jessica, CHEN Xuxiao, CHEN Yongjun |
| author_facet | CHANG Jessica, CHEN Xuxiao, CHEN Yongjun |
| author_sort | CHANG Jessica, CHEN Xuxiao, CHEN Yongjun |
| collection | DOAJ |
| description | The spleen is the largest lymphoid organ that can affect the immunological microenvironment in the liver via the portal system. Patients with liver cancer, often develop hypersplenism and splenomegaly from underlying cirrhosis and portal hypertension. The malfunction of the spleen not only induces hepatic fibrogenesis, but also changes the immune responses in the liver, so that liver cirrhosis accelerates while liver regeneration subdues. As a result, the hepatic microenvironment and the rest of the immune system reach a “tumor progressing” or “tumor tolerant” state. Splenectomy has been shown to improve immune responses, liver function and general condition in patients with liver cancer. Hence, splenectomy may possibly improve the tolerance in live cancer patients for other anticancer treatments. However, the long-term benefits and effects on the overall survival of concomitant hepatectomy and splenectomy for liver cancer patients with portal hypertension and hypersplenism still remain controversial. |
| first_indexed | 2024-03-11T15:32:30Z |
| format | Article |
| id | doaj.art-c7651b91ab704abea047ef723137e940 |
| institution | Directory Open Access Journal |
| issn | 1007-9610 |
| language | zho |
| last_indexed | 2024-03-11T15:32:30Z |
| publishDate | 2023-07-01 |
| publisher | Editorial Office of Journal of Surgery Concepts & Practice |
| record_format | Article |
| series | Waike lilun yu shijian |
| spelling | doaj.art-c7651b91ab704abea047ef723137e9402023-10-27T02:14:42ZzhoEditorial Office of Journal of Surgery Concepts & PracticeWaike lilun yu shijian1007-96102023-07-01280439439810.16139/j.1007-9610.2023.04.018Role of the spleen in patients with liver cancer and cirrhosisCHANG Jessica, CHEN Xuxiao, CHEN Yongjun0Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaThe spleen is the largest lymphoid organ that can affect the immunological microenvironment in the liver via the portal system. Patients with liver cancer, often develop hypersplenism and splenomegaly from underlying cirrhosis and portal hypertension. The malfunction of the spleen not only induces hepatic fibrogenesis, but also changes the immune responses in the liver, so that liver cirrhosis accelerates while liver regeneration subdues. As a result, the hepatic microenvironment and the rest of the immune system reach a “tumor progressing” or “tumor tolerant” state. Splenectomy has been shown to improve immune responses, liver function and general condition in patients with liver cancer. Hence, splenectomy may possibly improve the tolerance in live cancer patients for other anticancer treatments. However, the long-term benefits and effects on the overall survival of concomitant hepatectomy and splenectomy for liver cancer patients with portal hypertension and hypersplenism still remain controversial.https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1698117200426-1884798663.pdf|liver cancer|spleen|portal hypertension|cirrhosis |
| spellingShingle | CHANG Jessica, CHEN Xuxiao, CHEN Yongjun Role of the spleen in patients with liver cancer and cirrhosis Waike lilun yu shijian |liver cancer|spleen|portal hypertension|cirrhosis |
| title | Role of the spleen in patients with liver cancer and cirrhosis |
| title_full | Role of the spleen in patients with liver cancer and cirrhosis |
| title_fullStr | Role of the spleen in patients with liver cancer and cirrhosis |
| title_full_unstemmed | Role of the spleen in patients with liver cancer and cirrhosis |
| title_short | Role of the spleen in patients with liver cancer and cirrhosis |
| title_sort | role of the spleen in patients with liver cancer and cirrhosis |
| topic | |liver cancer|spleen|portal hypertension|cirrhosis |
| url | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1698117200426-1884798663.pdf |
| work_keys_str_mv | AT changjessicachenxuxiaochenyongjun roleofthespleeninpatientswithlivercancerandcirrhosis |