HIV and schistosomiasis in rural Zimbabwe: the association of Retinol-binding protein with disease progression, inflammation and mortality
Background: Vitamin A has widespread effects on immune function and is therefore interesting in HIV-infection. Retinol-binding protein (RBP or RBP4) is a negative acute-phase protein and a marker of vitamin A status. Our aim was to investigate the association of RBP with HIV progression, infection w...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-04-01
|
| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971215000211 |
| _version_ | 1819140914480676864 |
|---|---|
| author | Sebastian Ranzi Kotzé Rutendo Zinyama-Gutsire Per Kallestrup Christine Stabell Benn Exnevia Gomo Jan Gerstoft Govert van Dam Ole Hartvig Mortensen Henrik Ullum Christian Erikstrup |
| author_facet | Sebastian Ranzi Kotzé Rutendo Zinyama-Gutsire Per Kallestrup Christine Stabell Benn Exnevia Gomo Jan Gerstoft Govert van Dam Ole Hartvig Mortensen Henrik Ullum Christian Erikstrup |
| author_sort | Sebastian Ranzi Kotzé |
| collection | DOAJ |
| description | Background: Vitamin A has widespread effects on immune function and is therefore interesting in HIV-infection. Retinol-binding protein (RBP or RBP4) is a negative acute-phase protein and a marker of vitamin A status. Our aim was to investigate the association of RBP with HIV progression, infection with schistosomiasis, inflammatory cytokines, and mortality.
Methods: The study included 192 HIV-infected and 177 HIV-uninfected individuals from Mupfure in rural Zimbabwe. Of these, 208 were infected with Schistosoma haematobium, 27 with S. mansoni and 48 with both. Plasma RBP, HIV-RNA, CD4 cell count, haemoglobin, cytokines, clinical staging (CDC category), self-reported level of function (Karnoffsky Performance Score, KPS) and schistosomiasis status were assessed at baseline. Participants were followed up for survival 3-4 years post-enrolment.
Results: RBP levels were lower in HIV-infected individuals(p<0.0001). Among HIV-infected individuals, multivariable analysis showed RBP to be positively correlated with CD4 cell count(p=0.050), KPS(p=0.003), and haemoglobin(p<0.0001) and negatively correlated with HIV-RNA(p<0.0001), CDC category(p<0.0001), tumor necrosis factor-receptor II(p<0.0001) and interleukin(IL)-6(p=0.004), as well as with IL-8(p=0.005) and IL-10(p=0.003) for HIV-infected men. Furthermore, among HIV-infected individuals RBP correlated negatively with schistosomiasis(p=0.038) and intensity of infection: circulating anodic antigen(p=0.014), circulating cathodic antigen(p<0.0001) and faecal egg output(p=0.004).
Conclusions: In HIV-infected individuals, RBP was negatively associated with levels of inflammatory markers, markers of HIV progression, infection with schistosomiasis and markers of schistosomal intensity. |
| first_indexed | 2024-12-22T11:46:08Z |
| format | Article |
| id | doaj.art-c769ee1e961246a2abab54d97ab074a1 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 1878-3511 |
| language | English |
| last_indexed | 2024-12-22T11:46:08Z |
| publishDate | 2015-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-c769ee1e961246a2abab54d97ab074a12022-12-21T18:27:08ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112015-04-0133C15916410.1016/j.ijid.2015.01.015HIV and schistosomiasis in rural Zimbabwe: the association of Retinol-binding protein with disease progression, inflammation and mortalitySebastian Ranzi Kotzé0Rutendo Zinyama-Gutsire1Per Kallestrup2Christine Stabell Benn3Exnevia Gomo4Jan Gerstoft5Govert van Dam6Ole Hartvig Mortensen7Henrik Ullum8Christian Erikstrup9Department of Clinical Immunology, Aarhus University Hospital, Aarhus, DenmarkMedical Research Council of ZimbabweCenter for Global Health, Department of Public Health, Aarhus UniversityResearch Center for Vitamins and Vaccines, Bandim Health Project, Statens Serum Institut, Copenhagen, DenmarkDepartment of Medical Laboratory Sciences, University of Zimbabwe, Harare, ZimbabweFaculty of Health Sciences, and Cluster of International Health, University of Copenhagen, DenmarkDepartment of Parasitology, Leiden University Medical Centre, the NetherlandsCellular and Metabolic Research Section, Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, DenmarkDepartment of Clinical Immunology, Rigshospitalet, Copenhagen, DenmarkDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, DenmarkBackground: Vitamin A has widespread effects on immune function and is therefore interesting in HIV-infection. Retinol-binding protein (RBP or RBP4) is a negative acute-phase protein and a marker of vitamin A status. Our aim was to investigate the association of RBP with HIV progression, infection with schistosomiasis, inflammatory cytokines, and mortality. Methods: The study included 192 HIV-infected and 177 HIV-uninfected individuals from Mupfure in rural Zimbabwe. Of these, 208 were infected with Schistosoma haematobium, 27 with S. mansoni and 48 with both. Plasma RBP, HIV-RNA, CD4 cell count, haemoglobin, cytokines, clinical staging (CDC category), self-reported level of function (Karnoffsky Performance Score, KPS) and schistosomiasis status were assessed at baseline. Participants were followed up for survival 3-4 years post-enrolment. Results: RBP levels were lower in HIV-infected individuals(p<0.0001). Among HIV-infected individuals, multivariable analysis showed RBP to be positively correlated with CD4 cell count(p=0.050), KPS(p=0.003), and haemoglobin(p<0.0001) and negatively correlated with HIV-RNA(p<0.0001), CDC category(p<0.0001), tumor necrosis factor-receptor II(p<0.0001) and interleukin(IL)-6(p=0.004), as well as with IL-8(p=0.005) and IL-10(p=0.003) for HIV-infected men. Furthermore, among HIV-infected individuals RBP correlated negatively with schistosomiasis(p=0.038) and intensity of infection: circulating anodic antigen(p=0.014), circulating cathodic antigen(p<0.0001) and faecal egg output(p=0.004). Conclusions: In HIV-infected individuals, RBP was negatively associated with levels of inflammatory markers, markers of HIV progression, infection with schistosomiasis and markers of schistosomal intensity.http://www.sciencedirect.com/science/article/pii/S1201971215000211Retinol-binding proteinvitamin AHIVschistosomiasismortalityAfrica |
| spellingShingle | Sebastian Ranzi Kotzé Rutendo Zinyama-Gutsire Per Kallestrup Christine Stabell Benn Exnevia Gomo Jan Gerstoft Govert van Dam Ole Hartvig Mortensen Henrik Ullum Christian Erikstrup HIV and schistosomiasis in rural Zimbabwe: the association of Retinol-binding protein with disease progression, inflammation and mortality International Journal of Infectious Diseases Retinol-binding protein vitamin A HIV schistosomiasis mortality Africa |
| title | HIV and schistosomiasis in rural Zimbabwe: the association of Retinol-binding protein with disease progression, inflammation and mortality |
| title_full | HIV and schistosomiasis in rural Zimbabwe: the association of Retinol-binding protein with disease progression, inflammation and mortality |
| title_fullStr | HIV and schistosomiasis in rural Zimbabwe: the association of Retinol-binding protein with disease progression, inflammation and mortality |
| title_full_unstemmed | HIV and schistosomiasis in rural Zimbabwe: the association of Retinol-binding protein with disease progression, inflammation and mortality |
| title_short | HIV and schistosomiasis in rural Zimbabwe: the association of Retinol-binding protein with disease progression, inflammation and mortality |
| title_sort | hiv and schistosomiasis in rural zimbabwe the association of retinol binding protein with disease progression inflammation and mortality |
| topic | Retinol-binding protein vitamin A HIV schistosomiasis mortality Africa |
| url | http://www.sciencedirect.com/science/article/pii/S1201971215000211 |
| work_keys_str_mv | AT sebastianranzikotze hivandschistosomiasisinruralzimbabwetheassociationofretinolbindingproteinwithdiseaseprogressioninflammationandmortality AT rutendozinyamagutsire hivandschistosomiasisinruralzimbabwetheassociationofretinolbindingproteinwithdiseaseprogressioninflammationandmortality AT perkallestrup hivandschistosomiasisinruralzimbabwetheassociationofretinolbindingproteinwithdiseaseprogressioninflammationandmortality AT christinestabellbenn hivandschistosomiasisinruralzimbabwetheassociationofretinolbindingproteinwithdiseaseprogressioninflammationandmortality AT exneviagomo hivandschistosomiasisinruralzimbabwetheassociationofretinolbindingproteinwithdiseaseprogressioninflammationandmortality AT jangerstoft hivandschistosomiasisinruralzimbabwetheassociationofretinolbindingproteinwithdiseaseprogressioninflammationandmortality AT govertvandam hivandschistosomiasisinruralzimbabwetheassociationofretinolbindingproteinwithdiseaseprogressioninflammationandmortality AT olehartvigmortensen hivandschistosomiasisinruralzimbabwetheassociationofretinolbindingproteinwithdiseaseprogressioninflammationandmortality AT henrikullum hivandschistosomiasisinruralzimbabwetheassociationofretinolbindingproteinwithdiseaseprogressioninflammationandmortality AT christianerikstrup hivandschistosomiasisinruralzimbabwetheassociationofretinolbindingproteinwithdiseaseprogressioninflammationandmortality |