SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES
The issues of immune pathogenesis in autoimmune pathology are discussed in this review. The main attention is drawn to potential pathogenetic role of various suppressor cell populations, including T-regulatory cells, mesenchymal stem cells, myeloid lineage-derived suppressors. Homeostatic lymphocyte...
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| Format: | Article |
| Langue: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2016-04-01
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| Collection: | Медицинская иммунология |
| Sujets: | |
| Accès en ligne: | https://www.mimmun.ru/mimmun/article/view/983 |
| _version_ | 1826534225393745920 |
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| author | V. A. Kozlov |
| author_facet | V. A. Kozlov |
| author_sort | V. A. Kozlov |
| collection | DOAJ |
| description | The issues of immune pathogenesis in autoimmune pathology are discussed in this review. The main attention is drawn to potential pathogenetic role of various suppressor cell populations, including T-regulatory cells, mesenchymal stem cells, myeloid lineage-derived suppressors. Homeostatic lymphocyte proliferation is considered to be of great importance for pathogenesis of autoimmune disorders. Recent data from literature suggest that the autoimmune diseases are characterized by reduced activity of the mentioned suppressor cell populations, thus being a possible prerequisite for development of autoaggressive clones of cytotoxic lymphocytes, increased synthesis of autoantibodies leading to evolving autoimmune pathology. It should be, however, noted, that all these processes are accompanied by changes in the immune system induced by homeostatic proliferation of lymphoid cells. |
| first_indexed | 2024-03-08T05:50:05Z |
| format | Article |
| id | doaj.art-c76a2358048a46ad901b133150ad9122 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:19:38Z |
| publishDate | 2016-04-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-c76a2358048a46ad901b133150ad91222025-03-11T17:59:06ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2016-04-0118171410.15789/1563-0625-2016-1-7-14815SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASESV. A. Kozlov0Research Institute of Fundamental and Clinical ImmunologyThe issues of immune pathogenesis in autoimmune pathology are discussed in this review. The main attention is drawn to potential pathogenetic role of various suppressor cell populations, including T-regulatory cells, mesenchymal stem cells, myeloid lineage-derived suppressors. Homeostatic lymphocyte proliferation is considered to be of great importance for pathogenesis of autoimmune disorders. Recent data from literature suggest that the autoimmune diseases are characterized by reduced activity of the mentioned suppressor cell populations, thus being a possible prerequisite for development of autoaggressive clones of cytotoxic lymphocytes, increased synthesis of autoantibodies leading to evolving autoimmune pathology. It should be, however, noted, that all these processes are accompanied by changes in the immune system induced by homeostatic proliferation of lymphoid cells.https://www.mimmun.ru/mimmun/article/view/983autoimmunitysuppressor cellshomeostasislymphocyte proliferation |
| spellingShingle | V. A. Kozlov SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES Медицинская иммунология autoimmunity suppressor cells homeostasis lymphocyte proliferation |
| title | SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES |
| title_full | SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES |
| title_fullStr | SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES |
| title_full_unstemmed | SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES |
| title_short | SUPPRESSOR CELLS – THE BASIS OF IMMUNOPATHOGENESIS AUTOIMMUNE DISEASES |
| title_sort | suppressor cells the basis of immunopathogenesis autoimmune diseases |
| topic | autoimmunity suppressor cells homeostasis lymphocyte proliferation |
| url | https://www.mimmun.ru/mimmun/article/view/983 |
| work_keys_str_mv | AT vakozlov suppressorcellsthebasisofimmunopathogenesisautoimmunediseases |