Is the Macrophage Phenotype Determinant for Fibrosis Development?
Fibrosis is a pathophysiological process of wound repair that leads to the deposit of connective tissue in the extracellular matrix. This complication is mainly associated with different pathologies affecting several organs such as lung, liver, heart, kidney, and intestine. In this fibrotic process,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/12/1747 |
| _version_ | 1827674041268305920 |
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| author | Lluis Lis-López Cristina Bauset Marta Seco-Cervera Jesús Cosín-Roger |
| author_facet | Lluis Lis-López Cristina Bauset Marta Seco-Cervera Jesús Cosín-Roger |
| author_sort | Lluis Lis-López |
| collection | DOAJ |
| description | Fibrosis is a pathophysiological process of wound repair that leads to the deposit of connective tissue in the extracellular matrix. This complication is mainly associated with different pathologies affecting several organs such as lung, liver, heart, kidney, and intestine. In this fibrotic process, macrophages play an important role since they can modulate fibrosis due to their high plasticity, being able to adopt different phenotypes depending on the microenvironment in which they are found. In this review, we will try to discuss whether the macrophage phenotype exerts a pivotal role in the fibrosis development in the most important fibrotic scenarios. |
| first_indexed | 2024-03-10T04:34:05Z |
| format | Article |
| id | doaj.art-c76a466ab1874d24bfd546050df6caf0 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T04:34:05Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-c76a466ab1874d24bfd546050df6caf02023-11-23T03:54:56ZengMDPI AGBiomedicines2227-90592021-11-01912174710.3390/biomedicines9121747Is the Macrophage Phenotype Determinant for Fibrosis Development?Lluis Lis-López0Cristina Bauset1Marta Seco-Cervera2Jesús Cosín-Roger3Department of Pharmacology and CIBEREHD, Faculty of Medicine, University of Valencia, 46010 Valencia, SpainDepartment of Pharmacology and CIBEREHD, Faculty of Medicine, University of Valencia, 46010 Valencia, SpainHospital Dr. Peset, Fundación para la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, FISABIO, 46010 Valencia, SpainHospital Dr. Peset, Fundación para la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, FISABIO, 46010 Valencia, SpainFibrosis is a pathophysiological process of wound repair that leads to the deposit of connective tissue in the extracellular matrix. This complication is mainly associated with different pathologies affecting several organs such as lung, liver, heart, kidney, and intestine. In this fibrotic process, macrophages play an important role since they can modulate fibrosis due to their high plasticity, being able to adopt different phenotypes depending on the microenvironment in which they are found. In this review, we will try to discuss whether the macrophage phenotype exerts a pivotal role in the fibrosis development in the most important fibrotic scenarios.https://www.mdpi.com/2227-9059/9/12/1747macrophagespulmonary fibrosiscardiac fibrosisliver fibrosiskidney fibrosisintestinal fibrosis |
| spellingShingle | Lluis Lis-López Cristina Bauset Marta Seco-Cervera Jesús Cosín-Roger Is the Macrophage Phenotype Determinant for Fibrosis Development? Biomedicines macrophages pulmonary fibrosis cardiac fibrosis liver fibrosis kidney fibrosis intestinal fibrosis |
| title | Is the Macrophage Phenotype Determinant for Fibrosis Development? |
| title_full | Is the Macrophage Phenotype Determinant for Fibrosis Development? |
| title_fullStr | Is the Macrophage Phenotype Determinant for Fibrosis Development? |
| title_full_unstemmed | Is the Macrophage Phenotype Determinant for Fibrosis Development? |
| title_short | Is the Macrophage Phenotype Determinant for Fibrosis Development? |
| title_sort | is the macrophage phenotype determinant for fibrosis development |
| topic | macrophages pulmonary fibrosis cardiac fibrosis liver fibrosis kidney fibrosis intestinal fibrosis |
| url | https://www.mdpi.com/2227-9059/9/12/1747 |
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