Corneal deposition of fluoroquinolones after penetrating keratoplasty: case series
Sanjeeta Sitaula,1 Sanjay K Singh21B.P. Koirala Lions Centre for Ophthalmic Studies, Institute Of Medicine, Kathmandu, Nepal; 2Department of Cornea Clinic, Biratnagar Eye Hospital, Biratnagar, NepalPurpose: To report three cases of fluroquinolone deposition in the cornea after topical administration...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-05-01
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| Series: | International Medical Case Reports Journal |
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| Online Access: | https://www.dovepress.com/corneal-deposition-of-fluoroquinolones-after-penetrating-keratoplasty--peer-reviewed-article-IMCRJ |
| _version_ | 1819010724220895232 |
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| author | Sitaula S Singh SK |
| author_facet | Sitaula S Singh SK |
| author_sort | Sitaula S |
| collection | DOAJ |
| description | Sanjeeta Sitaula,1 Sanjay K Singh21B.P. Koirala Lions Centre for Ophthalmic Studies, Institute Of Medicine, Kathmandu, Nepal; 2Department of Cornea Clinic, Biratnagar Eye Hospital, Biratnagar, NepalPurpose: To report three cases of fluroquinolone deposition in the cornea after topical administration post-penetrating keratoplasty.Case reports: Herein we report three patients ranging in age from 42–65 years who underwent keratoplasty with cataract extraction, with intraocular lens implantation in the first two cases and left aphakic due to a posterior capsular tear in the third case. The first two patients received ciprofloxacin-dexamethasone combination drops, and developed drug deposition, which was observed at the first follow-up after 7 and 10 days respectively. The third patient received prednisolone acetate and ofloxacin eyedrops postoperatively, and developed drug deposits in the cornea after 20 days. In all of the three patients, the fluroquinolone group of drugs was discontinued and the cornea cleared gradually over the next 3–4 weeks. Although the cornea cleared, the first two grafts failed due to recurrent viral infection in one case, and graft rejection in the other case.Conclusion: Deposition of many different fluroquinolones in the cornea has been reported after a variety of surgeries, including penetrating keratoplasty. Drug deposition post-penetrating keratoplasty may seem innocuous due to self-resolution on cessation of the drugs, but it may have deleterious effects on graft survival. Hence, fluroquinolones, especially ciprofloxacin, should be cautiously used in patients undergoing penetrating keratoplasty if frequent dosing is prescribed or if used concurrently with other topical medications containing preservatives.Keywords: ciprofloxacin, corneal deposits, fluroquinolones, ofloxacin, penetrating keratoplasty |
| first_indexed | 2024-12-21T01:16:48Z |
| format | Article |
| id | doaj.art-c771402c519647529061d614f2f98919 |
| institution | Directory Open Access Journal |
| issn | 1179-142X |
| language | English |
| last_indexed | 2024-12-21T01:16:48Z |
| publishDate | 2019-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Medical Case Reports Journal |
| spelling | doaj.art-c771402c519647529061d614f2f989192022-12-21T19:20:46ZengDove Medical PressInternational Medical Case Reports Journal1179-142X2019-05-01Volume 1215115445691Corneal deposition of fluoroquinolones after penetrating keratoplasty: case seriesSitaula SSingh SKSanjeeta Sitaula,1 Sanjay K Singh21B.P. Koirala Lions Centre for Ophthalmic Studies, Institute Of Medicine, Kathmandu, Nepal; 2Department of Cornea Clinic, Biratnagar Eye Hospital, Biratnagar, NepalPurpose: To report three cases of fluroquinolone deposition in the cornea after topical administration post-penetrating keratoplasty.Case reports: Herein we report three patients ranging in age from 42–65 years who underwent keratoplasty with cataract extraction, with intraocular lens implantation in the first two cases and left aphakic due to a posterior capsular tear in the third case. The first two patients received ciprofloxacin-dexamethasone combination drops, and developed drug deposition, which was observed at the first follow-up after 7 and 10 days respectively. The third patient received prednisolone acetate and ofloxacin eyedrops postoperatively, and developed drug deposits in the cornea after 20 days. In all of the three patients, the fluroquinolone group of drugs was discontinued and the cornea cleared gradually over the next 3–4 weeks. Although the cornea cleared, the first two grafts failed due to recurrent viral infection in one case, and graft rejection in the other case.Conclusion: Deposition of many different fluroquinolones in the cornea has been reported after a variety of surgeries, including penetrating keratoplasty. Drug deposition post-penetrating keratoplasty may seem innocuous due to self-resolution on cessation of the drugs, but it may have deleterious effects on graft survival. Hence, fluroquinolones, especially ciprofloxacin, should be cautiously used in patients undergoing penetrating keratoplasty if frequent dosing is prescribed or if used concurrently with other topical medications containing preservatives.Keywords: ciprofloxacin, corneal deposits, fluroquinolones, ofloxacin, penetrating keratoplastyhttps://www.dovepress.com/corneal-deposition-of-fluoroquinolones-after-penetrating-keratoplasty--peer-reviewed-article-IMCRJciprofloxacincorneal depositsfluroquinolonesofloxacinpenetrating keratoplasty |
| spellingShingle | Sitaula S Singh SK Corneal deposition of fluoroquinolones after penetrating keratoplasty: case series International Medical Case Reports Journal ciprofloxacin corneal deposits fluroquinolones ofloxacin penetrating keratoplasty |
| title | Corneal deposition of fluoroquinolones after penetrating keratoplasty: case series |
| title_full | Corneal deposition of fluoroquinolones after penetrating keratoplasty: case series |
| title_fullStr | Corneal deposition of fluoroquinolones after penetrating keratoplasty: case series |
| title_full_unstemmed | Corneal deposition of fluoroquinolones after penetrating keratoplasty: case series |
| title_short | Corneal deposition of fluoroquinolones after penetrating keratoplasty: case series |
| title_sort | corneal deposition of fluoroquinolones after penetrating keratoplasty case series |
| topic | ciprofloxacin corneal deposits fluroquinolones ofloxacin penetrating keratoplasty |
| url | https://www.dovepress.com/corneal-deposition-of-fluoroquinolones-after-penetrating-keratoplasty--peer-reviewed-article-IMCRJ |
| work_keys_str_mv | AT sitaulas cornealdepositionoffluoroquinolonesafterpenetratingkeratoplastycaseseries AT singhsk cornealdepositionoffluoroquinolonesafterpenetratingkeratoplastycaseseries |