Ex Vivo Culture Models to Indicate Therapy Response in Head and Neck Squamous Cell Carcinoma
Head and neck squamous cell carcinoma (HNSCC) is characterized by a poor 5 year survival and varying response rates to both standard-of-care and new treatments. Despite advances in medicine and treatment methods, mortality rates have hardly decreased in recent decades. Reliable patient-derived tumor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/11/2527 |
| _version_ | 1797547087483633664 |
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| author | Imke Demers Johan Donkers Bernd Kremer Ernst Jan Speel |
| author_facet | Imke Demers Johan Donkers Bernd Kremer Ernst Jan Speel |
| author_sort | Imke Demers |
| collection | DOAJ |
| description | Head and neck squamous cell carcinoma (HNSCC) is characterized by a poor 5 year survival and varying response rates to both standard-of-care and new treatments. Despite advances in medicine and treatment methods, mortality rates have hardly decreased in recent decades. Reliable patient-derived tumor models offer the chance to predict therapy response in a personalized setting, thereby improving treatment efficacy by identifying the most appropriate treatment regimen for each patient. Furthermore, ex vivo tumor models enable testing of novel therapies before introduction in clinical practice. A literature search was performed to identify relevant literature describing three-dimensional ex vivo culture models of HNSCC to examine sensitivity to chemotherapy, radiotherapy, immunotherapy and targeted therapy. We provide a comprehensive overview of the currently used three-dimensional ex vivo culture models for HNSCC with their advantages and limitations, including culture success percentage and comparison to the original tumor. Furthermore, we evaluate the potential of these models to predict patient therapy response. |
| first_indexed | 2024-03-10T14:39:21Z |
| format | Article |
| id | doaj.art-c77205f893174948b7bd175646f59a00 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T14:39:21Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-c77205f893174948b7bd175646f59a002023-11-20T21:58:13ZengMDPI AGCells2073-44092020-11-01911252710.3390/cells9112527Ex Vivo Culture Models to Indicate Therapy Response in Head and Neck Squamous Cell CarcinomaImke Demers0Johan Donkers1Bernd Kremer2Ernst Jan Speel3Department of Pathology, GROW-school for Oncology and Development Biology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The NetherlandsDepartment of Otorhinolaryngology, Head and Neck Surgery, GROW-School for Oncology and Development Biology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The NetherlandsDepartment of Otorhinolaryngology, Head and Neck Surgery, GROW-School for Oncology and Development Biology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The NetherlandsDepartment of Pathology, GROW-school for Oncology and Development Biology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The NetherlandsHead and neck squamous cell carcinoma (HNSCC) is characterized by a poor 5 year survival and varying response rates to both standard-of-care and new treatments. Despite advances in medicine and treatment methods, mortality rates have hardly decreased in recent decades. Reliable patient-derived tumor models offer the chance to predict therapy response in a personalized setting, thereby improving treatment efficacy by identifying the most appropriate treatment regimen for each patient. Furthermore, ex vivo tumor models enable testing of novel therapies before introduction in clinical practice. A literature search was performed to identify relevant literature describing three-dimensional ex vivo culture models of HNSCC to examine sensitivity to chemotherapy, radiotherapy, immunotherapy and targeted therapy. We provide a comprehensive overview of the currently used three-dimensional ex vivo culture models for HNSCC with their advantages and limitations, including culture success percentage and comparison to the original tumor. Furthermore, we evaluate the potential of these models to predict patient therapy response.https://www.mdpi.com/2073-4409/9/11/2527head and neck cancerprimary cell culture3D cell culturepersonalized therapypreclinical prediction modelsensitivity testing |
| spellingShingle | Imke Demers Johan Donkers Bernd Kremer Ernst Jan Speel Ex Vivo Culture Models to Indicate Therapy Response in Head and Neck Squamous Cell Carcinoma Cells head and neck cancer primary cell culture 3D cell culture personalized therapy preclinical prediction model sensitivity testing |
| title | Ex Vivo Culture Models to Indicate Therapy Response in Head and Neck Squamous Cell Carcinoma |
| title_full | Ex Vivo Culture Models to Indicate Therapy Response in Head and Neck Squamous Cell Carcinoma |
| title_fullStr | Ex Vivo Culture Models to Indicate Therapy Response in Head and Neck Squamous Cell Carcinoma |
| title_full_unstemmed | Ex Vivo Culture Models to Indicate Therapy Response in Head and Neck Squamous Cell Carcinoma |
| title_short | Ex Vivo Culture Models to Indicate Therapy Response in Head and Neck Squamous Cell Carcinoma |
| title_sort | ex vivo culture models to indicate therapy response in head and neck squamous cell carcinoma |
| topic | head and neck cancer primary cell culture 3D cell culture personalized therapy preclinical prediction model sensitivity testing |
| url | https://www.mdpi.com/2073-4409/9/11/2527 |
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