Coenzyme Q10 Stimulate Reproductive Vatality
Xinyu Nie,1,2 Xinru Dong,1,2 Yuge Hu,1,2 Fangjun Xu,1 Cong Hu,2 Chang Shu1 1Obstetrics and Gynecology Center, First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2Reproductive Medicine Center, Prenatal Diagnosis Center, First Hospital of Jilin University, Changchun, Jil...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-08-01
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| Series: | Drug Design, Development and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/coenzyme-q10-stimulate-reproductive-vatality-peer-reviewed-fulltext-article-DDDT |
| _version_ | 1827855081302654976 |
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| author | Nie X Dong X Hu Y Xu F Hu C Shu C |
| author_facet | Nie X Dong X Hu Y Xu F Hu C Shu C |
| author_sort | Nie X |
| collection | DOAJ |
| description | Xinyu Nie,1,2 Xinru Dong,1,2 Yuge Hu,1,2 Fangjun Xu,1 Cong Hu,2 Chang Shu1 1Obstetrics and Gynecology Center, First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2Reproductive Medicine Center, Prenatal Diagnosis Center, First Hospital of Jilin University, Changchun, Jilin, People’s Republic of ChinaCorrespondence: Chang Shu, Email shu_chang@jlu.edu.cnAbstract: Female infertility and pregnancy maintenance are associate with various factors, including quantity and quality of oocytes, genital inflammation, endometriosis, and other diseases. Women are even diagnosed as unexplained infertility or unexplained recurrent spontaneous abortion when failed to achieve pregnancy with current treatment, which are urgent clinical issues need to be addressed. Coenzyme Q10 (CoQ10) is a lipid-soluble electron carrier in the mitochondrial electron transport chain. It is not only essential for the mitochondria to produce energy, but also function as an antioxidant to maintain redox homeostasis in the body. Recently, the capacity of CoQ10 to reduce oxidative stress (OS), enhance mitochondrial activity, regulate gene expression and inhibit inflammatory responses, has been discovered as a novel adjuvant in male reproductive performance enhancing in both animal and human studies. Furthermore, CoQ10 is also proved to regulate immune balance, antioxidant, promote glucose and lipid metabolism. These properties will bring highlight for ovarian dysfunction reversing, ovulation ameliorating, oocyte maturation/fertilization promoting, and embryonic development optimizing. In this review, we systematically discuss the pleiotropic effects of CoQ10 in female reproductive disorders to investigate the mechanism and therapeutic potential to provide a reference in subsequent studies.Keywords: coenzyme Q10, oxidative stress, reactive oxygen species, reproductive, oocyte, endometriosis |
| first_indexed | 2024-03-12T11:39:57Z |
| format | Article |
| id | doaj.art-c773d759dcf6405d8562c6f2b69f6e76 |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-03-12T11:39:57Z |
| publishDate | 2023-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-c773d759dcf6405d8562c6f2b69f6e762023-08-31T19:08:36ZengDove Medical PressDrug Design, Development and Therapy1177-88812023-08-01Volume 172623263786308Coenzyme Q10 Stimulate Reproductive VatalityNie XDong XHu YXu FHu CShu CXinyu Nie,1,2 Xinru Dong,1,2 Yuge Hu,1,2 Fangjun Xu,1 Cong Hu,2 Chang Shu1 1Obstetrics and Gynecology Center, First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2Reproductive Medicine Center, Prenatal Diagnosis Center, First Hospital of Jilin University, Changchun, Jilin, People’s Republic of ChinaCorrespondence: Chang Shu, Email shu_chang@jlu.edu.cnAbstract: Female infertility and pregnancy maintenance are associate with various factors, including quantity and quality of oocytes, genital inflammation, endometriosis, and other diseases. Women are even diagnosed as unexplained infertility or unexplained recurrent spontaneous abortion when failed to achieve pregnancy with current treatment, which are urgent clinical issues need to be addressed. Coenzyme Q10 (CoQ10) is a lipid-soluble electron carrier in the mitochondrial electron transport chain. It is not only essential for the mitochondria to produce energy, but also function as an antioxidant to maintain redox homeostasis in the body. Recently, the capacity of CoQ10 to reduce oxidative stress (OS), enhance mitochondrial activity, regulate gene expression and inhibit inflammatory responses, has been discovered as a novel adjuvant in male reproductive performance enhancing in both animal and human studies. Furthermore, CoQ10 is also proved to regulate immune balance, antioxidant, promote glucose and lipid metabolism. These properties will bring highlight for ovarian dysfunction reversing, ovulation ameliorating, oocyte maturation/fertilization promoting, and embryonic development optimizing. In this review, we systematically discuss the pleiotropic effects of CoQ10 in female reproductive disorders to investigate the mechanism and therapeutic potential to provide a reference in subsequent studies.Keywords: coenzyme Q10, oxidative stress, reactive oxygen species, reproductive, oocyte, endometriosishttps://www.dovepress.com/coenzyme-q10-stimulate-reproductive-vatality-peer-reviewed-fulltext-article-DDDTcoenzyme q10oxidative stressreactive oxygen speciesreproductiveoocyteendometriosis |
| spellingShingle | Nie X Dong X Hu Y Xu F Hu C Shu C Coenzyme Q10 Stimulate Reproductive Vatality Drug Design, Development and Therapy coenzyme q10 oxidative stress reactive oxygen species reproductive oocyte endometriosis |
| title | Coenzyme Q10 Stimulate Reproductive Vatality |
| title_full | Coenzyme Q10 Stimulate Reproductive Vatality |
| title_fullStr | Coenzyme Q10 Stimulate Reproductive Vatality |
| title_full_unstemmed | Coenzyme Q10 Stimulate Reproductive Vatality |
| title_short | Coenzyme Q10 Stimulate Reproductive Vatality |
| title_sort | coenzyme q10 stimulate reproductive vatality |
| topic | coenzyme q10 oxidative stress reactive oxygen species reproductive oocyte endometriosis |
| url | https://www.dovepress.com/coenzyme-q10-stimulate-reproductive-vatality-peer-reviewed-fulltext-article-DDDT |
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