Heterologous mRNA-protein vaccination with Tc24 induces a robust cellular immune response against Trypanosoma cruzi, characterized by an increased level of polyfunctional CD8+ T-cells

Heterologous mRNA-protein vaccination with Tc24 induces a robust cellular immune response against Trypanosoma cruzi, characterized by an increased level of polyfunctional CD8+ T-cells

Tc24 is a Trypanosoma cruzi-derived flagellar protein that, when formulated with a TLR-4 agonist adjuvant, induces a balanced immune response in mice, elevating IgG2a antibody titers and IFN-γ levels. Furthermore, vaccination with the recombinant Tc24 protein can reduce parasite levels and improve s...

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Bibliographic Details
Main Authors: Cristina Poveda, Ana Carolina Leão, Chiara Mancino, Francesca Taraballi, Yi-Lin Chen, Rakesh Adhikari, Maria Jose Villar, Rakhi Kundu, Duc M. Nguyen, Leroy Versteeg, Ulrich Strych, Peter J. Hotez, Maria Elena Bottazzi, Jeroen Pollet, Kathryn M. Jones
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Current Research in Immunology
Subjects:
Chagas disease
Immunogenicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2590255523000124

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