Pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia: A case report and review of the literature
Low-risk gestational trophoblastic neoplasia (GTN) is generally treated with single agent chemotherapy, including methotrexate (MTX) or dactinomycin. We present a case of a patient with low-risk GTN who underwent single agent MTX therapy, developed Pneumocystis jirovecii pneumonia (PJP), recovered,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Gynecologic Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S235257892300303X |
| _version_ | 1797390506284548096 |
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| author | Hector S. Porragas-Paseiro Steven Johnson Lindsay Brubaker Brooke E. Sanders |
| author_facet | Hector S. Porragas-Paseiro Steven Johnson Lindsay Brubaker Brooke E. Sanders |
| author_sort | Hector S. Porragas-Paseiro |
| collection | DOAJ |
| description | Low-risk gestational trophoblastic neoplasia (GTN) is generally treated with single agent chemotherapy, including methotrexate (MTX) or dactinomycin. We present a case of a patient with low-risk GTN who underwent single agent MTX therapy, developed Pneumocystis jirovecii pneumonia (PJP), recovered, and ultimately completed consolidation treatment for GTN on single agent MTX. While MTX administration is associated with an increased risk of PJP, this association is best described in rheumatology literature. This is the first case of PJP complicating MTX therapy within the gynecologic oncology literature. |
| first_indexed | 2024-03-08T23:11:52Z |
| format | Article |
| id | doaj.art-c774e567b1374d609b9f2fb086be60f2 |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-03-08T23:11:52Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-c774e567b1374d609b9f2fb086be60f22023-12-15T07:24:48ZengElsevierGynecologic Oncology Reports2352-57892023-12-0150101286Pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia: A case report and review of the literatureHector S. Porragas-Paseiro0Steven Johnson1Lindsay Brubaker2Brooke E. Sanders3University of Colorado, Department of Obstetrics and Gynecology; Division of Gynecologic Oncology, USA; Corresponding author at: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Colorado School of Medicine, 12631 East 17th Avenue, Room 4414, B198-4, Aurora, CO 80045, USA.University of Colorado, Department of Infectious Diseases, USAUniversity of Colorado, Department of Obstetrics and Gynecology; Division of Gynecologic Oncology, USAUniversity of Colorado, Department of Obstetrics and Gynecology; Division of Gynecologic Oncology, USALow-risk gestational trophoblastic neoplasia (GTN) is generally treated with single agent chemotherapy, including methotrexate (MTX) or dactinomycin. We present a case of a patient with low-risk GTN who underwent single agent MTX therapy, developed Pneumocystis jirovecii pneumonia (PJP), recovered, and ultimately completed consolidation treatment for GTN on single agent MTX. While MTX administration is associated with an increased risk of PJP, this association is best described in rheumatology literature. This is the first case of PJP complicating MTX therapy within the gynecologic oncology literature.http://www.sciencedirect.com/science/article/pii/S235257892300303XGestational trophoblastic neoplasiaMethotrexatePneumocystis Jirovecii Pneumonia |
| spellingShingle | Hector S. Porragas-Paseiro Steven Johnson Lindsay Brubaker Brooke E. Sanders Pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia: A case report and review of the literature Gynecologic Oncology Reports Gestational trophoblastic neoplasia Methotrexate Pneumocystis Jirovecii Pneumonia |
| title | Pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia: A case report and review of the literature |
| title_full | Pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia: A case report and review of the literature |
| title_fullStr | Pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia: A case report and review of the literature |
| title_full_unstemmed | Pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia: A case report and review of the literature |
| title_short | Pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low-risk post-molar gestational trophoblastic neoplasia: A case report and review of the literature |
| title_sort | pneumocystis jirovecii pneumonia complicating methotrexate treatment in a patient with low risk post molar gestational trophoblastic neoplasia a case report and review of the literature |
| topic | Gestational trophoblastic neoplasia Methotrexate Pneumocystis Jirovecii Pneumonia |
| url | http://www.sciencedirect.com/science/article/pii/S235257892300303X |
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