A volumetric magnetic resonance imaging study in migraine
Abstract Background Although migraine phenotype has been widely described, the explanation of migraine pathophysiology still has a gap that might be partly bridged by neuroimaging investigations. The aim of the study is to assess volumetric brain changes in migraineurs compared with controls, and in...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-08-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-021-00372-7 |
| _version_ | 1831762825723248640 |
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| author | Laila Elmously Naguib Ghada Saed Abdel Azim Mohammed Abdelrazek Abdellatif |
| author_facet | Laila Elmously Naguib Ghada Saed Abdel Azim Mohammed Abdelrazek Abdellatif |
| author_sort | Laila Elmously Naguib |
| collection | DOAJ |
| description | Abstract Background Although migraine phenotype has been widely described, the explanation of migraine pathophysiology still has a gap that might be partly bridged by neuroimaging investigations. The aim of the study is to assess volumetric brain changes in migraineurs compared with controls, and in episodic migraine in comparison to chronic type. Structural brain changes in migraineurs (with and without aura) were assessed by an automated segmentation method (Free Surfer). T1-weighted MRIs of 25 migraineurs (14 diagnosed as episodic type and 11 diagnosed as chronic migraine) and 25 headache-free controls were evaluated and processed. Results Migraine patients had significant reduction of the volume of total brain, grey matter, brain stem, cerebellum, basal ganglia, thalamus, hippocampus and amygdala in comparison to control subjects. Patients with chronic migraine had significant reduction in volume of total brain, grey matter, cerebellum and frontal lobe thickness in comparison to those with episodic migraine. Conclusion Migraineurs showed volumetric brain changes mainly in areas related to central processing of pain and in areas specific for migraine (such as brain stem) when compared to healthy controls. Chronic migraineurs showed significant reduction in grey matter, in areas involved in processing of pain, cognition and multisensory integration versus patients with episodic migraine, which adds insight into the pathophysiology of migraine as a progressive disorder that may have long-term impacts on the brain as regards structure and function. |
| first_indexed | 2024-12-22T05:14:11Z |
| format | Article |
| id | doaj.art-c77640e6a1b642d290e756606d1248b6 |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-12-22T05:14:11Z |
| publishDate | 2021-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-c77640e6a1b642d290e756606d1248b62022-12-21T18:37:54ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292021-08-0157111110.1186/s41983-021-00372-7A volumetric magnetic resonance imaging study in migraineLaila Elmously Naguib0Ghada Saed Abdel Azim1Mohammed Abdelrazek Abdellatif2The Department of Neurology, Faculty of Medicine-for Girls, Al Azhar UniversityThe Department of Neurology, Faculty of Medicine-for Girls, Al Azhar UniversityDiagnostic Radiology Department, Faculty of Medicine-for Boys, Al Azhar UniversityAbstract Background Although migraine phenotype has been widely described, the explanation of migraine pathophysiology still has a gap that might be partly bridged by neuroimaging investigations. The aim of the study is to assess volumetric brain changes in migraineurs compared with controls, and in episodic migraine in comparison to chronic type. Structural brain changes in migraineurs (with and without aura) were assessed by an automated segmentation method (Free Surfer). T1-weighted MRIs of 25 migraineurs (14 diagnosed as episodic type and 11 diagnosed as chronic migraine) and 25 headache-free controls were evaluated and processed. Results Migraine patients had significant reduction of the volume of total brain, grey matter, brain stem, cerebellum, basal ganglia, thalamus, hippocampus and amygdala in comparison to control subjects. Patients with chronic migraine had significant reduction in volume of total brain, grey matter, cerebellum and frontal lobe thickness in comparison to those with episodic migraine. Conclusion Migraineurs showed volumetric brain changes mainly in areas related to central processing of pain and in areas specific for migraine (such as brain stem) when compared to healthy controls. Chronic migraineurs showed significant reduction in grey matter, in areas involved in processing of pain, cognition and multisensory integration versus patients with episodic migraine, which adds insight into the pathophysiology of migraine as a progressive disorder that may have long-term impacts on the brain as regards structure and function.https://doi.org/10.1186/s41983-021-00372-7Brain volumeEpisodic migraineChronic migraineMagnetic resonance imaging |
| spellingShingle | Laila Elmously Naguib Ghada Saed Abdel Azim Mohammed Abdelrazek Abdellatif A volumetric magnetic resonance imaging study in migraine The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Brain volume Episodic migraine Chronic migraine Magnetic resonance imaging |
| title | A volumetric magnetic resonance imaging study in migraine |
| title_full | A volumetric magnetic resonance imaging study in migraine |
| title_fullStr | A volumetric magnetic resonance imaging study in migraine |
| title_full_unstemmed | A volumetric magnetic resonance imaging study in migraine |
| title_short | A volumetric magnetic resonance imaging study in migraine |
| title_sort | volumetric magnetic resonance imaging study in migraine |
| topic | Brain volume Episodic migraine Chronic migraine Magnetic resonance imaging |
| url | https://doi.org/10.1186/s41983-021-00372-7 |
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