Fyn tyrosine kinase increases Apolipoprotein E Receptor 2 levels and phosphorylation.
Apolipoprotein E Receptor 2 (ApoER2) and the tyrosine kinase Fyn are both members of the Reelin pathway, a signaling pathway essential for the laminar formation of the cortex during development and proper dendritic spine density and long-term potential (LTP) in the adult brain. In the presence of ex...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4207760?pdf=render |
| _version_ | 1818848156294578176 |
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| author | Teal C Burrell Shailaja D Divekar Edwin J Weeber G William Rebeck |
| author_facet | Teal C Burrell Shailaja D Divekar Edwin J Weeber G William Rebeck |
| author_sort | Teal C Burrell |
| collection | DOAJ |
| description | Apolipoprotein E Receptor 2 (ApoER2) and the tyrosine kinase Fyn are both members of the Reelin pathway, a signaling pathway essential for the laminar formation of the cortex during development and proper dendritic spine density and long-term potential (LTP) in the adult brain. In the presence of extracellular Reelin, ApoER2 binds the intracellular protein Dab1, an adaptor protein that is phosphorylated by Fyn. However, direct interactions between ApoER2 and Fyn are not well defined. Here, we show that total levels of ApoER2 and surface levels of ApoER2 are increased by active Fyn. Via a separate mechanism, ApoER2 is also phosphorylated by Fyn, an event that peaks in the postnatal cortex at day 5 and can occur at multiple ApoER2 tyrosine residues. Dab1 is also involved in this phosphorylation, promoting the phosphorylation of ApoER2 by Fyn when it is itself phosphorylated. These results elucidate some of the intracellular mechanisms that give rise to a functional Reelin pathway. |
| first_indexed | 2024-12-19T06:12:52Z |
| format | Article |
| id | doaj.art-c77746498cab476a97718d67319719d1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T06:12:52Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c77746498cab476a97718d67319719d12022-12-21T20:32:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01910e11084510.1371/journal.pone.0110845Fyn tyrosine kinase increases Apolipoprotein E Receptor 2 levels and phosphorylation.Teal C BurrellShailaja D DivekarEdwin J WeeberG William RebeckApolipoprotein E Receptor 2 (ApoER2) and the tyrosine kinase Fyn are both members of the Reelin pathway, a signaling pathway essential for the laminar formation of the cortex during development and proper dendritic spine density and long-term potential (LTP) in the adult brain. In the presence of extracellular Reelin, ApoER2 binds the intracellular protein Dab1, an adaptor protein that is phosphorylated by Fyn. However, direct interactions between ApoER2 and Fyn are not well defined. Here, we show that total levels of ApoER2 and surface levels of ApoER2 are increased by active Fyn. Via a separate mechanism, ApoER2 is also phosphorylated by Fyn, an event that peaks in the postnatal cortex at day 5 and can occur at multiple ApoER2 tyrosine residues. Dab1 is also involved in this phosphorylation, promoting the phosphorylation of ApoER2 by Fyn when it is itself phosphorylated. These results elucidate some of the intracellular mechanisms that give rise to a functional Reelin pathway.http://europepmc.org/articles/PMC4207760?pdf=render |
| spellingShingle | Teal C Burrell Shailaja D Divekar Edwin J Weeber G William Rebeck Fyn tyrosine kinase increases Apolipoprotein E Receptor 2 levels and phosphorylation. PLoS ONE |
| title | Fyn tyrosine kinase increases Apolipoprotein E Receptor 2 levels and phosphorylation. |
| title_full | Fyn tyrosine kinase increases Apolipoprotein E Receptor 2 levels and phosphorylation. |
| title_fullStr | Fyn tyrosine kinase increases Apolipoprotein E Receptor 2 levels and phosphorylation. |
| title_full_unstemmed | Fyn tyrosine kinase increases Apolipoprotein E Receptor 2 levels and phosphorylation. |
| title_short | Fyn tyrosine kinase increases Apolipoprotein E Receptor 2 levels and phosphorylation. |
| title_sort | fyn tyrosine kinase increases apolipoprotein e receptor 2 levels and phosphorylation |
| url | http://europepmc.org/articles/PMC4207760?pdf=render |
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