The role of oxidative stress in the etiopathogenesis of gluten-sensitive enteropathy disease
Background: The objective here is to examine the role of overall oxidative stress in the etiopathogenesis of glutensensitive enteropathy disease and its relationship with gluten free diet and autoantibodies. Methods: Eighty gluten-sensitive enteropathy patients and 80 control group participants were...
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| Format: | Article |
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Society of Medical Biochemists of Serbia, Belgrade
2017-01-01
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| Series: | Journal of Medical Biochemistry |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2017/1452-82581703243M.pdf |
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| author | Mustafa Kaplan Ihsan Ates Yüksel Mahmut Ozderin-Ozin Yasemin Yener-Akpinar Muhammed Topcuoglu Canan Ertugrul Kayaçetin |
| author_facet | Mustafa Kaplan Ihsan Ates Yüksel Mahmut Ozderin-Ozin Yasemin Yener-Akpinar Muhammed Topcuoglu Canan Ertugrul Kayaçetin |
| author_sort | Mustafa Kaplan |
| collection | DOAJ |
| description | Background: The objective here is to examine the role of overall oxidative stress in the etiopathogenesis of glutensensitive enteropathy disease and its relationship with gluten free diet and autoantibodies. Methods: Eighty gluten-sensitive enteropathy patients and 80 control group participants were included in the study. As oxidative stress parameters, we researched total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase-1 and arylesterase parameters in the serum samples of gluten-sensitive enteropathy patients. Results: In comparison to the control group, gluten-sensitive enteropathy patients had lower TAS, paraoxonase-1 and arylesterase levels and gluten-sensitive enteropathy patients had considerable TOS and OSI levels. In contrast, patients who agreed to the gluten free eating routine had a higher OSI proportion and patients who did not conform to the gluten free eating regimen had a lower paraoxonase1 level. An affirming reciprocation was detected amidst TOS and OSI proportion and gluten-sensitive enteropathy autoantibodies and C-reactive protein levels and a negative correlation was found between arylesterase level and gluten-sensitive enteropathy autoantibodies. Conclusions: We observed oxidative stress levels to be higher in gluten-sensitive enteropathy patients contrasted with the control group. Oxidative stress level showed differences in gluten-sensitive enteropathy patients depending on gluten diet content and autoantibody positivity. In point of fact, C-reactive protein and gluten-sensitive enteropathy autoantibodies are identified with oxidative anxiety parameters resulting in the possibility that oxidative stress might be successful in the gluten-sensitive enteropathy pathogenesis. |
| first_indexed | 2024-04-13T03:01:55Z |
| format | Article |
| id | doaj.art-c7795146c6ea49e186b92792cb900e08 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-04-13T03:01:55Z |
| publishDate | 2017-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-c7795146c6ea49e186b92792cb900e082022-12-22T03:05:24ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662017-01-013632432501452-82581703243MThe role of oxidative stress in the etiopathogenesis of gluten-sensitive enteropathy diseaseMustafa Kaplan0Ihsan Ates1Yüksel Mahmut2Ozderin-Ozin Yasemin3Yener-Akpinar Muhammed4Topcuoglu Canan5Ertugrul Kayaçetin6Turkey Yuksek Ihtisas Training and Research Hospital, Department of Gastroenterology, Ankara, TurkeyAnkara Numune Training and Research Hospital, Department of Internal Medicine, Ankara, TurkeyTurkey Yuksek Ihtisas Training and Research Hospital, Department of Gastroenterology, Ankara, TurkeyTurkey Yuksek Ihtisas Training and Research Hospital, Department of Gastroenterology, Ankara, TurkeyTurkey Yuksek Ihtisas Training and Research Hospital, Department of Gastroenterology, Ankara, TurkeyAnkara Numune Training and Research Hospital, Department of Biochemistry, Ankara, TurkeyTurkey Yuksek Ihtisas Training and Research Hospital, Department of Gastroenterology, Ankara, TurkeyBackground: The objective here is to examine the role of overall oxidative stress in the etiopathogenesis of glutensensitive enteropathy disease and its relationship with gluten free diet and autoantibodies. Methods: Eighty gluten-sensitive enteropathy patients and 80 control group participants were included in the study. As oxidative stress parameters, we researched total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase-1 and arylesterase parameters in the serum samples of gluten-sensitive enteropathy patients. Results: In comparison to the control group, gluten-sensitive enteropathy patients had lower TAS, paraoxonase-1 and arylesterase levels and gluten-sensitive enteropathy patients had considerable TOS and OSI levels. In contrast, patients who agreed to the gluten free eating routine had a higher OSI proportion and patients who did not conform to the gluten free eating regimen had a lower paraoxonase1 level. An affirming reciprocation was detected amidst TOS and OSI proportion and gluten-sensitive enteropathy autoantibodies and C-reactive protein levels and a negative correlation was found between arylesterase level and gluten-sensitive enteropathy autoantibodies. Conclusions: We observed oxidative stress levels to be higher in gluten-sensitive enteropathy patients contrasted with the control group. Oxidative stress level showed differences in gluten-sensitive enteropathy patients depending on gluten diet content and autoantibody positivity. In point of fact, C-reactive protein and gluten-sensitive enteropathy autoantibodies are identified with oxidative anxiety parameters resulting in the possibility that oxidative stress might be successful in the gluten-sensitive enteropathy pathogenesis.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2017/1452-82581703243M.pdfoxidative stress indexserum paraoxonase 1 / arylesterasetotal antioxidant statustotal oxidant status |
| spellingShingle | Mustafa Kaplan Ihsan Ates Yüksel Mahmut Ozderin-Ozin Yasemin Yener-Akpinar Muhammed Topcuoglu Canan Ertugrul Kayaçetin The role of oxidative stress in the etiopathogenesis of gluten-sensitive enteropathy disease Journal of Medical Biochemistry oxidative stress index serum paraoxonase 1 / arylesterase total antioxidant status total oxidant status |
| title | The role of oxidative stress in the etiopathogenesis of gluten-sensitive enteropathy disease |
| title_full | The role of oxidative stress in the etiopathogenesis of gluten-sensitive enteropathy disease |
| title_fullStr | The role of oxidative stress in the etiopathogenesis of gluten-sensitive enteropathy disease |
| title_full_unstemmed | The role of oxidative stress in the etiopathogenesis of gluten-sensitive enteropathy disease |
| title_short | The role of oxidative stress in the etiopathogenesis of gluten-sensitive enteropathy disease |
| title_sort | role of oxidative stress in the etiopathogenesis of gluten sensitive enteropathy disease |
| topic | oxidative stress index serum paraoxonase 1 / arylesterase total antioxidant status total oxidant status |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2017/1452-82581703243M.pdf |
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