Bone turnover and bone mineral density in old persons with type 2 diabetes
Aims: To understand the paradox of an increased fracture risk despite increased bone mineral density (BMD) in persons with type 2 diabetes (DM2). Patients and Methods: We studied 80 old persons with DM2. Mineral metabolism, parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHD), bone turnover – oste...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-12-01
|
| Series: | Journal of Clinical & Translational Endocrinology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214623718300541 |
| _version_ | 1818478055198294016 |
|---|---|
| author | João Martin Martins Patrícia Aranha |
| author_facet | João Martin Martins Patrícia Aranha |
| author_sort | João Martin Martins |
| collection | DOAJ |
| description | Aims: To understand the paradox of an increased fracture risk despite increased bone mineral density (BMD) in persons with type 2 diabetes (DM2). Patients and Methods: We studied 80 old persons with DM2. Mineral metabolism, parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHD), bone turnover – osteocalcin, procollagen type 1 N-terminal propeptide (P1NP) and C-terminal telopeptide of type 1 collagen (CTX) – were measured and BMD was assessed at the lumbar spine (LS) and femoral neck (FN). Data was analyzed with the Statistical Package for the Social Sciences Program. Results: Low levels of 25OHD (84%) and high values of PTH (20%) were found. Osteocalcin was directly related to CTX, p < 0.001, with increased bone formation and increased BMD (z-score) at LS and FN. PTH was directly related to osteocalcin and CTX and inversely related to BMD at the FN, p < 0.05. Patients with dyslipidemia presented higher P1NP, p < 0.05 and patients with hypertension presented higher BMD at LS and FN, p < 0.01. Conclusion: Old type 2 diabetics present increased bone formation, PTH-driven. Low grade secondary hyperparathyroidism may explain the paradox of an increased fracture risk despite increased BMD. Keywords: Diabetes Mellitus, Old age, Bone mineral density, Bone turnover, Parathyroid hormone |
| first_indexed | 2024-12-10T09:43:28Z |
| format | Article |
| id | doaj.art-c77a34d07b364a688ac6cc3d4aecfd21 |
| institution | Directory Open Access Journal |
| issn | 2214-6237 |
| language | English |
| last_indexed | 2024-12-10T09:43:28Z |
| publishDate | 2018-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical & Translational Endocrinology |
| spelling | doaj.art-c77a34d07b364a688ac6cc3d4aecfd212022-12-22T01:53:56ZengElsevierJournal of Clinical & Translational Endocrinology2214-62372018-12-01141218Bone turnover and bone mineral density in old persons with type 2 diabetesJoão Martin Martins0Patrícia Aranha1Endocrine Department, Hospital Santa Maria, 6th Floor, Avenida Professor Egas Moniz, 1649-028 Lisboa, Portugal; Endocrine University Clinic, Lisbon Medical School, Avenida Professor Egas Moniz, 1649-028 Lisboa, Portugal; Corresponding author at: Serviço de Endocrinologia, Piso 6, Hospital de Santa Maria, Avenida Professor Egas Moniz, 1649-028 Lisboa, Portugal.Internal Medicine Department, Hospital Santa Maria, 3rd Floor, Avenida Professor Egas Moniz, 1649-028 Lisboa, PortugalAims: To understand the paradox of an increased fracture risk despite increased bone mineral density (BMD) in persons with type 2 diabetes (DM2). Patients and Methods: We studied 80 old persons with DM2. Mineral metabolism, parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHD), bone turnover – osteocalcin, procollagen type 1 N-terminal propeptide (P1NP) and C-terminal telopeptide of type 1 collagen (CTX) – were measured and BMD was assessed at the lumbar spine (LS) and femoral neck (FN). Data was analyzed with the Statistical Package for the Social Sciences Program. Results: Low levels of 25OHD (84%) and high values of PTH (20%) were found. Osteocalcin was directly related to CTX, p < 0.001, with increased bone formation and increased BMD (z-score) at LS and FN. PTH was directly related to osteocalcin and CTX and inversely related to BMD at the FN, p < 0.05. Patients with dyslipidemia presented higher P1NP, p < 0.05 and patients with hypertension presented higher BMD at LS and FN, p < 0.01. Conclusion: Old type 2 diabetics present increased bone formation, PTH-driven. Low grade secondary hyperparathyroidism may explain the paradox of an increased fracture risk despite increased BMD. Keywords: Diabetes Mellitus, Old age, Bone mineral density, Bone turnover, Parathyroid hormonehttp://www.sciencedirect.com/science/article/pii/S2214623718300541 |
| spellingShingle | João Martin Martins Patrícia Aranha Bone turnover and bone mineral density in old persons with type 2 diabetes Journal of Clinical & Translational Endocrinology |
| title | Bone turnover and bone mineral density in old persons with type 2 diabetes |
| title_full | Bone turnover and bone mineral density in old persons with type 2 diabetes |
| title_fullStr | Bone turnover and bone mineral density in old persons with type 2 diabetes |
| title_full_unstemmed | Bone turnover and bone mineral density in old persons with type 2 diabetes |
| title_short | Bone turnover and bone mineral density in old persons with type 2 diabetes |
| title_sort | bone turnover and bone mineral density in old persons with type 2 diabetes |
| url | http://www.sciencedirect.com/science/article/pii/S2214623718300541 |
| work_keys_str_mv | AT joaomartinmartins boneturnoverandbonemineraldensityinoldpersonswithtype2diabetes AT patriciaaranha boneturnoverandbonemineraldensityinoldpersonswithtype2diabetes |