Mesoporous Silica Particles Functionalized with Newly Extracted Fish Oil (Omeg@Silica) Reducing IL-8 Counteract Cell Migration in NSCLC Cell Lines
Lung cancer is one of the leading forms of cancer in developed countries. Interleukin-8 (IL-8), a pro-inflammatory cytokine, exerts relevant effects in cancer growth and progression, including angiogenesis and metastasis in lung cancer. Mesoporous silica particles, functionalized with newly extracte...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/10/2079 |
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| author | Claudia D’Anna Caterina Di Sano Serena Di Vincenzo Simona Taverna Giuseppe Cammarata Antonino Scurria Mario Pagliaro Rosaria Ciriminna Elisabetta Pace |
| author_facet | Claudia D’Anna Caterina Di Sano Serena Di Vincenzo Simona Taverna Giuseppe Cammarata Antonino Scurria Mario Pagliaro Rosaria Ciriminna Elisabetta Pace |
| author_sort | Claudia D’Anna |
| collection | DOAJ |
| description | Lung cancer is one of the leading forms of cancer in developed countries. Interleukin-8 (IL-8), a pro-inflammatory cytokine, exerts relevant effects in cancer growth and progression, including angiogenesis and metastasis in lung cancer. Mesoporous silica particles, functionalized with newly extracted fish oil (Omeg@Silica), are more effective than the fish oil alone in anti-proliferative and pro-apoptotic effects in non-small cell lung cancer (NSCLC) cell lines. The mechanisms that explain this efficacy are not yet understood. The aim of the present study is therefore to decipher the anti-cancer effects of a formulation of Omeg@Silica in aqueous ethanol (FOS) in adenocarcinoma (A549) and muco-epidermoid (NCI-H292) lung cancer cells, evaluating cell migration, as well as IL-8, NF-κB, and miRNA-21 expression. Results show that in both cell lines, FOS was more efficient than oil alone, in decreasing cell migration and IL-8 gene expression. FOS reduced IL-8 protein release in both cell lines, but this effect was only stronger than the oil alone in A549. In A549, FOS was able to reduce miRNA-21 and transcription factor NF-κB nuclear expression. Taken together, these data support the potential use of the Omeg@Silica as an add-on therapy for NSCLC. Dedicated studies which prove clinical efficacy are needed. |
| first_indexed | 2024-03-09T19:35:54Z |
| format | Article |
| id | doaj.art-c77a55f633994a41ab9792aee4c7ea37 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T19:35:54Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-c77a55f633994a41ab9792aee4c7ea372023-11-24T01:55:24ZengMDPI AGPharmaceutics1999-49232022-09-011410207910.3390/pharmaceutics14102079Mesoporous Silica Particles Functionalized with Newly Extracted Fish Oil (Omeg@Silica) Reducing IL-8 Counteract Cell Migration in NSCLC Cell LinesClaudia D’Anna0Caterina Di Sano1Serena Di Vincenzo2Simona Taverna3Giuseppe Cammarata4Antonino Scurria5Mario Pagliaro6Rosaria Ciriminna7Elisabetta Pace8Istituto di Farmacologia Traslazionale, CNR, Via U. La Malfa 153, 90146 Palermo, ItalyIstituto di Farmacologia Traslazionale, CNR, Via U. La Malfa 153, 90146 Palermo, ItalyIstituto di Farmacologia Traslazionale, CNR, Via U. La Malfa 153, 90146 Palermo, ItalyIstituto di Farmacologia Traslazionale, CNR, Via U. La Malfa 153, 90146 Palermo, ItalyIstituto di Farmacologia Traslazionale, CNR, Via U. La Malfa 153, 90146 Palermo, ItalyIstituto per lo Studio dei Materiali Nanostrutturati, CNR, Via U. La Malfa 153, 90146 Palermo, ItalyIstituto per lo Studio dei Materiali Nanostrutturati, CNR, Via U. La Malfa 153, 90146 Palermo, ItalyIstituto per lo Studio dei Materiali Nanostrutturati, CNR, Via U. La Malfa 153, 90146 Palermo, ItalyIstituto di Farmacologia Traslazionale, CNR, Via U. La Malfa 153, 90146 Palermo, ItalyLung cancer is one of the leading forms of cancer in developed countries. Interleukin-8 (IL-8), a pro-inflammatory cytokine, exerts relevant effects in cancer growth and progression, including angiogenesis and metastasis in lung cancer. Mesoporous silica particles, functionalized with newly extracted fish oil (Omeg@Silica), are more effective than the fish oil alone in anti-proliferative and pro-apoptotic effects in non-small cell lung cancer (NSCLC) cell lines. The mechanisms that explain this efficacy are not yet understood. The aim of the present study is therefore to decipher the anti-cancer effects of a formulation of Omeg@Silica in aqueous ethanol (FOS) in adenocarcinoma (A549) and muco-epidermoid (NCI-H292) lung cancer cells, evaluating cell migration, as well as IL-8, NF-κB, and miRNA-21 expression. Results show that in both cell lines, FOS was more efficient than oil alone, in decreasing cell migration and IL-8 gene expression. FOS reduced IL-8 protein release in both cell lines, but this effect was only stronger than the oil alone in A549. In A549, FOS was able to reduce miRNA-21 and transcription factor NF-κB nuclear expression. Taken together, these data support the potential use of the Omeg@Silica as an add-on therapy for NSCLC. Dedicated studies which prove clinical efficacy are needed.https://www.mdpi.com/1999-4923/14/10/2079omega-3lung cancer cellscancer cell migrationinflammationfish oilPUFA |
| spellingShingle | Claudia D’Anna Caterina Di Sano Serena Di Vincenzo Simona Taverna Giuseppe Cammarata Antonino Scurria Mario Pagliaro Rosaria Ciriminna Elisabetta Pace Mesoporous Silica Particles Functionalized with Newly Extracted Fish Oil (Omeg@Silica) Reducing IL-8 Counteract Cell Migration in NSCLC Cell Lines Pharmaceutics omega-3 lung cancer cells cancer cell migration inflammation fish oil PUFA |
| title | Mesoporous Silica Particles Functionalized with Newly Extracted Fish Oil (Omeg@Silica) Reducing IL-8 Counteract Cell Migration in NSCLC Cell Lines |
| title_full | Mesoporous Silica Particles Functionalized with Newly Extracted Fish Oil (Omeg@Silica) Reducing IL-8 Counteract Cell Migration in NSCLC Cell Lines |
| title_fullStr | Mesoporous Silica Particles Functionalized with Newly Extracted Fish Oil (Omeg@Silica) Reducing IL-8 Counteract Cell Migration in NSCLC Cell Lines |
| title_full_unstemmed | Mesoporous Silica Particles Functionalized with Newly Extracted Fish Oil (Omeg@Silica) Reducing IL-8 Counteract Cell Migration in NSCLC Cell Lines |
| title_short | Mesoporous Silica Particles Functionalized with Newly Extracted Fish Oil (Omeg@Silica) Reducing IL-8 Counteract Cell Migration in NSCLC Cell Lines |
| title_sort | mesoporous silica particles functionalized with newly extracted fish oil omeg silica reducing il 8 counteract cell migration in nsclc cell lines |
| topic | omega-3 lung cancer cells cancer cell migration inflammation fish oil PUFA |
| url | https://www.mdpi.com/1999-4923/14/10/2079 |
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