Low nephron endowment increases susceptibility to renal stress and chronic kidney disease

Low nephron endowment increases susceptibility to renal stress and chronic kidney disease

Preterm birth results in low nephron endowment and increased risk of acute kidney injury (AKI) and chronic kidney disease (CKD). To understand the pathogenesis of AKI and CKD in preterm humans, we generated potentially novel mouse models with a 30%–70% reduction in nephron number by inhibiting or de...

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Bibliographic Details
Main Authors: Pamela I. Good, Ling Li, Holly A. Hurst, Ileana Serrano Herrera, Katherine Xu, Meenakshi Rao, David A. Bateman, Qais Al-Awqati, Vivette D. D’Agati, Frank Costantini, Fangming Lin
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-02-01
Series:JCI Insight
Subjects:
Nephrology
Online Access:https://doi.org/10.1172/jci.insight.161316

Internet

https://doi.org/10.1172/jci.insight.161316

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